Molecular Mechanisms Related to Burns, Burn Wound Healing and Scarring 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1416
Special Issue Editors
2. COREMED—Cooperative Centre for Regenerative Medicine, Joanneum Research GmbH, Neue Stiftingtal Str., 2, A-8010 Graz, Austria
Interests: plastic surgery; burn care; tissue engineering; regenerative medicine; wound healing; outcome measures; high-impact leadership; circular economy; sustainability
Special Issues, Collections and Topics in MDPI journals
Interests: burn; trauma; stress response; inflammation; hypermetabolism, including insulin resistance; cell regeneration; gene transfer; stem cells
Interests: responsible aesthetics; plastic surgery; rhinoplasty; facial surgery; wound healing; regenerative medicine
Special Issue Information
Dear Colleagues,
Burn injury is a complex traumatic event with various local, regional, and systemic effects. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, the inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury, and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn-care-related research. Conversely, inflammation is a necessary component in the later-stage processes of wound healing. Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now, up to 70% of patients develop hypertrophic scars after burns. Functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing patients’ quality of life and delaying their reintegration into society. Approaches to optimizing the healing potential of burn wounds use targeted wound care and surgery to minimize the development of hypertrophic scarring. Such approaches often fail, and the modulation of the established scar is continued, although the optimal indication, timing, and combination of therapies are yet to be established. The need for novel treatments is paramount, and future efforts to improve patients’ outcomes and quality of life should include the optimization of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and the further elucidation of molecular mechanisms to allow the development of new preventive and therapeutic strategies. In this Special Issue of IJMS, we are looking for articles which deliver a profound insight into the current science of burn wound pathophysiology, burn wound healing, and scarring.
Prof. Dr. Lars-Peter Kamolz
Prof. Dr. Marc Jeschke
Dr. Sebastian P. Nischwitz
Guest Editors
Manuscript Submission Information
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