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Biology
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Innovative Strategies in Musculoskeletal Regeneration
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Innovative Strategies in Musculoskeletal Regeneration

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (4 July 2023) | Viewed by 3484

Special Issue Editor

Prof. Dr. Umile Giuseppe Longo

E-Mail Website
Guest Editor
Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Interests: sports traumatology; arthroscopic surgery of shoulder, knee, and ankle; replacement surgery of shoulder, knee, and hip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We cordially invite you to contribute to a Special Issue of Innovative Strategies in Musculoskeletal Regeneration.

Tissue engineering has improved markedly with the advancement of research and technology in musculoskeletal regenerative medicine, becoming increasingly interdisciplinary. Numerous findings in molecular carriers involved in the formation of bones, muscles, and nerves have been described in recent years. Furthermore, researchers have been able to produce synthetic and biocompatible tissues due to the advancement of novel biomaterials and the use of endogenous cells.

These advancements have helped to develop a holistic view of the musculoskeletal system, improving knowledge of disorders and potential treatments. The most important lines of research that have been developed during the last years are drug and gene delivery, 3D/4D bioprinting technologies, innovative biomaterials, nanomaterials, nanotechnologies, engineered devices, biomechanics, bioreactors, and computational approaches.

The purpose of this Special Issue is to collect recent findings on molecular mechanisms, innovative diagnostic and therapeutic approaches in the field of musculoskeletal tissue regeneration.

Prof. Dr. Umile Giuseppe Longo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • orthopedic 
  • musculoskeletal disorders 
  • molecular chaperones 
  • regenerative medicine 
  • gene delivery 
  • scaffolds 
  • nanomaterials 
  • nanotechnologies 
  • biomaterials 
  • 3D/4D bioprinting

Published Papers (2 papers)

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Research

10 pages, 1217 KiB  
Article
Genetic Characterization in Familial Rotator Cuff Tear: An Exome Sequencing Study
by Alessia Azzarà, Laura Risi Ambrogioni, Ilaria Cassano, Carla Lintas, Umile Giuseppe Longo, Vincenzo Denaro and Fiorella Gurrieri
Biology 2022, 11(11), 1565; https://doi.org/10.3390/biology11111565 - 25 Oct 2022
Cited by 2 | Viewed by 1018
Abstract
Background: multiple gene variants seem to contribute to rotator cuff (RC) tear susceptibility. The aim of the study is to perform an exome sequencing analysis within a family to identify rare gene variants predisposing to the development of RC tear. Material and methods: [...] Read more.
Background: multiple gene variants seem to contribute to rotator cuff (RC) tear susceptibility. The aim of the study is to perform an exome sequencing analysis within a family to identify rare gene variants predisposing to the development of RC tear. Material and methods: the exome sequencing was conducted in a family consisting of four individuals, two healthy and the remaining ones with bilateral RC tears. Variants in common among the two affected subjects were selected, and those in common with the healthy subject and those with a frequency >1% were removed. The potential pathogenicity of the variants was investigated using the predictions of several in silico tools from VarSome. Results: the exome sequencing yielded approximately 600,000 variants per patient, subsequently filtered according to frequency <1% and absence of association with other diseases. Removing variants common with the healthy subject, 348 rare variants among 248 genes were identified. Based on the risk of damaging, three candidate genes for RC tear were found: COL23A1, EMILIN3, and HDAC10. Conclusion: this is the first whole-exome sequencing analysis within a family to explore genetic predisposition in RC tear. The results reveal the presence of common damaging variants among affected individuals in the COL23A1, EMILIN3, and HDAC10 genes. Full article
(This article belongs to the Special Issue Innovative Strategies in Musculoskeletal Regeneration)
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8 pages, 768 KiB  
Article
Influence of Rigor Mortis on Tendon Mobility in an Animal Fresh Cadaver Model
by Christoph Luecke, Marc Schnetzke, Christel Weiss, Stefan Studier-Fischer, Thorsten Guehring, Paul A. Gruetzner and Felix Porschke
Biology 2022, 11(10), 1381; https://doi.org/10.3390/biology11101381 - 22 Sep 2022
Viewed by 2020
Abstract
(1) Many biomechanical studies are performed using fresh frozen cadavers or embalmed specimens, although the biomechanical characteristics do not match the characteristics of in vivo tendons. Therefore, a fresh in vivo-like cadaver model has been introduced recently. As a limitation for studies with [...] Read more.
(1) Many biomechanical studies are performed using fresh frozen cadavers or embalmed specimens, although the biomechanical characteristics do not match the characteristics of in vivo tendons. Therefore, a fresh in vivo-like cadaver model has been introduced recently. As a limitation for studies with fresh cadavers, rigor mortis must be considered. The aim of this study was to evaluate the impact of the biomechanical properties and time of occurrence of rigor mortis in a fresh cadaver model. (2) For this study, 15 fresh porcine cadaver shoulders were used in an established biomechanical in vitro model to evaluate the onset of rigor mortis. Measurements took place at ten points of time (t1–t10) beginning 103 min post mortem (pm). The mobility of the supraspinatus tendon was measured in Newton (N) with a modified sensor-enhanced arthroscopic grasper. (3) The mean load measured at the time point t1 was 28.0 ± 11.2 N. The first significant decrease of mobility occurred 151 min post mortem (t4) at a mean load of 30.2 ± 13.7 N. From 227 min pm to 317 min pm, there was no further significant increase. (4) Tendon mobility decreases significantly within the first three hours after the killing. Therefore, reliable results can be obtained within 150 min post mortem before the onset of rigor mortis alters the biomechanical properties. Full article
(This article belongs to the Special Issue Innovative Strategies in Musculoskeletal Regeneration)
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