Dear Colleagues,

It is widely reported that cancer development is associated with the activity of reactive oxygen species (ROS). Elevated levels of ROS, which are usually detected in malignant cells, can be caused by several mechanisms, e.g., an increased metabolic rate, mitochondrial dysfunction, or changes in enzymes associated with ROS metabolic pathways. Therefore, ROS may play an important role in oncogenesis, contributing to genetic instability and inducing a proliferative response by activating multiple proliferative mechanisms, including NF-κB signalling. In terms of cell biology, there is a balance between the rate of ROS production and their elimination by antioxidant enzymes.

The most significant function in the maintenance of this balance is performed by antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), xanthine oxidoreductase (XOR), and glutathione reductase (GR). Although these enzymes have different structures and are located in different organelles within cells, from a physiological point of view, they form one coherent antioxidant protection system. Understanding the activity, expression level, and role of these enzymes in cancer cells may have important clinical relevance in terms of predicting survival or modifying anti-cancer therapies.

In this Special Issue, we aim to provide insight into how pro- and anti-tumorigenic antioxidant enzymes act during cancer development and progression, as well as how their regulation, via antioxidant defence, could be manipulated for the treatment of cancer.

Dr. Marlena Brzozowa-Zasada
Dr. Angela Ianaro
Guest Editors

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• antioxidative enzymes
• ROS
• oxidative stress
• reductive stress
• cancer development
• metastasis
• prognostic activity
• oxygen