Special Issue "Antioxidant Enzymes in Cancer Biology"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 1546

Special Issue Editors

Department of Histology and Cell Pathology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland
Interests: histology; colon adenocarcinoma; cancer biology; cancer metabolism; signaling pathways; antioxidative enzymes
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy
Interests: anti-oxidant enzymes; ROS; oxidative stress; cancer metabolism; tumor progression; apoptosis; autophagy; NFκB pathway; tumor adaptation; drug resistance; angiogenesis; metastasis; tumor targeting; gasotransmitters

Special Issue Information

Dear Colleagues,

It is widely reported that cancer development is associated with the activity of reactive oxygen species (ROS). Elevated levels of ROS, which are usually detected in malignant cells, can be caused by several mechanisms, e.g., an increased metabolic rate, mitochondrial dysfunction, or changes in enzymes associated with ROS metabolic pathways. Therefore, ROS may play an important role in oncogenesis, contributing to genetic instability and inducing a proliferative response by activating multiple proliferative mechanisms, including NF-κB signalling. In terms of cell biology, there is a balance between the rate of ROS production and their elimination by antioxidant enzymes.

The most significant function in the maintenance of this balance is performed by antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), xanthine oxidoreductase (XOR), and glutathione reductase (GR). Although these enzymes have different structures and are located in different organelles within cells, from a physiological point of view, they form one coherent antioxidant protection system. Understanding the activity, expression level, and role of these enzymes in cancer cells may have important clinical relevance in terms of predicting survival or modifying anti-cancer therapies.

In this Special Issue, we aim to provide insight into how pro- and anti-tumorigenic antioxidant enzymes act during cancer development and progression, as well as how their regulation, via antioxidant defence, could be manipulated for the treatment of cancer.

Dr. Marlena Brzozowa-Zasada
Dr. Angela Ianaro
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antioxidative enzymes
  • ROS
  • oxidative stress
  • reductive stress
  • cancer development
  • metastasis
  • prognostic activity
  • oxygen

Published Papers (1 paper)

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25 pages, 6228 KiB  
Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties
Antioxidants 2023, 12(6), 1217; https://doi.org/10.3390/antiox12061217 - 05 Jun 2023
Cited by 3 | Viewed by 1210
Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more vulnerable to further ROS elevation than normal cells. Nevertheless, [...] Read more.
Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more vulnerable to further ROS elevation than normal cells. Nevertheless, dynamic redox evolution and adaptation of tumor cells are capable of counteracting therapy-induced oxidative stress, which leads to chemoresistance. Hence, exploring the cytoprotective mechanisms of tumor cells is urgently needed to overcome chemoresistance. Heme oxygenase-1 (HO-1), a rate-limiting enzyme of heme degradation, acts as a crucial antioxidant defense and cytoprotective molecule in response to cellular stress. Recently, emerging evidence indicated that ROS detoxification and oxidative stress tolerance owing to the antioxidant function of HO-1 contribute to chemoresistance in various cancers. Enhanced HO-1 expression or enzymatic activity was revealed to promote apoptosis resistance and activate protective autophagy, which also involved in the development of chemoresistance. Moreover, inhibition of HO-1 in multiple cancers was identified to reversing chemoresistance or improving chemosensitivity. Here, we summarize the most recent advances regarding the antioxidant, antiapoptotic, and pro-autophagy properties of HO-1 in mediating chemoresistance, highlighting HO-1 as a novel target for overcoming chemoresistance and improving the prognosis of cancer patients. Full article
(This article belongs to the Special Issue Antioxidant Enzymes in Cancer Biology)
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