Special Issue "Antioxidant Enzymes in Cancer Biology"
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 1546
Interests: histology; colon adenocarcinoma; cancer biology; cancer metabolism; signaling pathways; antioxidative enzymes
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Interests: anti-oxidant enzymes; ROS; oxidative stress; cancer metabolism; tumor progression; apoptosis; autophagy; NFκB pathway; tumor adaptation; drug resistance; angiogenesis; metastasis; tumor targeting; gasotransmitters
It is widely reported that cancer development is associated with the activity of reactive oxygen species (ROS). Elevated levels of ROS, which are usually detected in malignant cells, can be caused by several mechanisms, e.g., an increased metabolic rate, mitochondrial dysfunction, or changes in enzymes associated with ROS metabolic pathways. Therefore, ROS may play an important role in oncogenesis, contributing to genetic instability and inducing a proliferative response by activating multiple proliferative mechanisms, including NF-κB signalling. In terms of cell biology, there is a balance between the rate of ROS production and their elimination by antioxidant enzymes.
The most significant function in the maintenance of this balance is performed by antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), xanthine oxidoreductase (XOR), and glutathione reductase (GR). Although these enzymes have different structures and are located in different organelles within cells, from a physiological point of view, they form one coherent antioxidant protection system. Understanding the activity, expression level, and role of these enzymes in cancer cells may have important clinical relevance in terms of predicting survival or modifying anti-cancer therapies.
In this Special Issue, we aim to provide insight into how pro- and anti-tumorigenic antioxidant enzymes act during cancer development and progression, as well as how their regulation, via antioxidant defence, could be manipulated for the treatment of cancer.
Dr. Marlena Brzozowa-Zasada
Dr. Angela Ianaro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antioxidative enzymes
- oxidative stress
- reductive stress
- cancer development
- prognostic activity