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Special Issue "The Role of Signaling Pathways in Gastrointestinal Cancer Pathogenesis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 180

Special Issue Editor

Department of Histology and Cell Pathology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland
Interests: colon cancer; gastric cancer; Notch signaling pathway; glutathione in cancer; antioxidant enzymes
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Special Issue Information

Dear Colleagues,

Many studies have shown that alterations in signaling pathways are associated with the development of cancer. These include those that play an important role in the initiation, development and spread of malignant tumors, such as the Wnt/beta-catenin signaling pathway, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, the Notch signaling pathway and the nuclear factor-kappa-beta (NF-kB) signaling pathway. Pharmacological inhibitors and antibody-based drugs that target altered components of the signaling pathways or downstream proteins are expected to have a significant impact on cancer treatment and therapy. Unfortunately, the complex system of the tumor signaling network poses a major challenge to the development of such anti-cancer drugs because of the redundancy of the pathways that regulate cell proliferation and survival. In addition, factors in the tumor microenvironment may stimulate alternative pathways that maintain cell viability, despite the inhibition of target pathways. Therefore, a better understanding of these signaling pathways—especially at the molecular level—may improve oncologists' ability to predict prognosis and response to treatment. We especially invite articles related to the field of signaling pathways at the molecular level for submission to this Special Issue.

Dr. Marlena Brzozowa-Zasada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • signaling pathways
  • cancer
  • therapeutic antibodies
  • targeted therapy
  • metastasis

Published Papers

This special issue is now open for submission.
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