Special Issue "The Role of Signaling Pathways in Gastrointestinal Cancer Pathogenesis"
Deadline for manuscript submissions: 31 October 2023 | Viewed by 180
Interests: colon cancer; gastric cancer; Notch signaling pathway; glutathione in cancer; antioxidant enzymes
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Many studies have shown that alterations in signaling pathways are associated with the development of cancer. These include those that play an important role in the initiation, development and spread of malignant tumors, such as the Wnt/beta-catenin signaling pathway, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, the Notch signaling pathway and the nuclear factor-kappa-beta (NF-kB) signaling pathway. Pharmacological inhibitors and antibody-based drugs that target altered components of the signaling pathways or downstream proteins are expected to have a significant impact on cancer treatment and therapy. Unfortunately, the complex system of the tumor signaling network poses a major challenge to the development of such anti-cancer drugs because of the redundancy of the pathways that regulate cell proliferation and survival. In addition, factors in the tumor microenvironment may stimulate alternative pathways that maintain cell viability, despite the inhibition of target pathways. Therefore, a better understanding of these signaling pathways—especially at the molecular level—may improve oncologists' ability to predict prognosis and response to treatment. We especially invite articles related to the field of signaling pathways at the molecular level for submission to this Special Issue.
Dr. Marlena Brzozowa-Zasada
Manuscript Submission Information
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- signaling pathways
- therapeutic antibodies
- targeted therapy