Special Issue "The Role of Glutathione Metabolism in Health and Disease"
Deadline for manuscript submissions: 30 December 2023 | Viewed by 254
Interests: colon cancer; gastric cancer; Notch signaling pathway; glutathione in cancer; antioxidant enzymes
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Glutathione (GSH) is essential for several antioxidant processes and appears to be the most important non-enzymatic antioxidant in cells. For example, it acts as a regulator of the cellular redox state to protect cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. GSH has also been shown to participate in key signalling pathways and to regulate, e.g., proliferation or apoptosis. One of the most important roles of GSH is its involvement in the regeneration of enzymatic and non-enzymatic antioxidants. Cancer initiation, progression, and response to treatment have been linked to molecular alterations in the GSH antioxidant system and disruption of GSH homeostasis. It is also worth noting that in healthy cells it is essential for removing and detoxifying carcinogens, whereas elevated GSH levels in cancer cells have been linked to tumour progression and increased resistance to chemotherapeutic drugs.
Therefore, a better understanding of the role of GSH in health and diseases, including cancer, especially at the molecular level, may improve prognosis and treatment response. For this Special Issue, we invite manuscripts on the role of GSH (and enzymes which are connected with GSH activity) in healthy cells and pathological tissues.
Dr. Marlena Brzozowa-Zasada
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- glutathione metabolism
- glutathione activity
- reactive oxygen species (ROS)