Novel Advances in Sustained and Controlled Release Drug Delivery Systems

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (30 July 2021) | Viewed by 3483

Special Issue Editors


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Guest Editor
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China
Interests: dug delivery; pharmaceutics; oral delivery; controlled and sustained release; pharmaceutical technology
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Guest Editor
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 511436, China
Interests: modern TCM preparations; micro/nanoparticle-based drug delivery systems; nanotherapy with phytomedicines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sustained and controlled release drug delivery systems (SCRDDS) are designed to release a drug at a predetermined rate utilizing a tailor-made formulation or carrier. SCRDDS enables the slow release of a drug over an extended period after a single administration and maintains smooth levels of the drug in the blood for a long time, thus achieving the potentiation and attenuation of a medication. Considerable efforts have been focused on the development of SCRDDS to address the challenge of formulating drugs with significant biopharmaceutical/pharmacokinetic issues. The ultimate goal of developing SCRDDS is to regulate and control drug release in vitro and in vivo by designing rational dosage forms, to improve the curative effects of a drug. To date, there is still much room for the optimization of drug-release rates and sites.

This Special Issue “Novel Advances in Sustained and Controlled Release Drug Delivery Systems” aims to assemble the current advances in the development and application of SCRDDS to optimize the in vivo pharmacokinetic profiles and therapeutic actions of therapeutic drugs. Topics of interest include, but are not limited to:

  • The rationales for sustained/controlled drug delivery;
  • Techniques for sustained/controlled drug delivery;
  • The design and evaluation of sustained/controlled drug-delivery systems;
  • Applications of sustained/controlled drug-delivery systems.

Prof. Dr. Wei Wu
Dr. Xingwang Zhang
Guest Editors

Manuscript Submission Information

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Keywords

  • sustained release
  • controlled release
  • drug delivery system
  • dosage form
  • formulation
  • pharmacokinetics

Published Papers (1 paper)

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Research

16 pages, 6779 KiB  
Article
Formulation, In Vitro and In Vivo Evaluation of Gefitinib Solid Dispersions Prepared Using Different Techniques
by Sultan Alshehri, Abdullah Alanazi, Ehab M. Elzayat, Mohammad A. Altamimi, Syed S. Imam, Afzal Hussain, Faleh Alqahtani and Faiyaz Shakeel
Processes 2021, 9(7), 1210; https://doi.org/10.3390/pr9071210 - 14 Jul 2021
Cited by 18 | Viewed by 2413
Abstract
Gefitinib (Gef) is a poorly water-soluble antitumor drug, which shows poor absorption/bioavailability after oral administration. Therefore, this study was carried out to develop Gef solid dispersions (SDs) using different carriers and different techniques in order to enhance its dissolution and oral absorption/bioavailability. Various [...] Read more.
Gefitinib (Gef) is a poorly water-soluble antitumor drug, which shows poor absorption/bioavailability after oral administration. Therefore, this study was carried out to develop Gef solid dispersions (SDs) using different carriers and different techniques in order to enhance its dissolution and oral absorption/bioavailability. Various SD formulations of Gef were established using fusion and microwave methods utilizing Soluplus, Kollidone VA64, and polyethylene glycol 4000 (PEG 4000) as the carriers. Developed SDs of Gef were characterized physicochemically and evaluated for in vitro dissolution and in vivo pharmacokinetic studies. The physicochemical evaluation revealed the formation of Gef SDs using fusion and microwave methods. In vitro dissolution studies indicated significant release of Gef from all SDs compared to the pure Gef. Optimized SD of Gef (S2-MW) presented significant release of Gef (82.10%) compared with pure Gef (21.23%). The optimized Gef SD (S2) was subjected to in vivo pharmacokinetic evaluation in comparison with pure Gef in rats. The results indicated significant enhancement in various pharmacokinetic parameters of Gef from an optimized SD S2 compared to the pure Gef. In addition, Gef-SD S2 resulted in remarkable improvement in bioavailability compared to the pure Gef. Overall, this study suggested that the prepared Gef-SD by microwave method showed marked enhancement in dissolution and bioavailability. Full article
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