Special Issue "Plant Bioactive Compounds: Extraction, Encapsulation, Characterization and Pharmacological Potential"
Deadline for manuscript submissions: 30 April 2024 | Viewed by 10308
Interests: natural product chemistry; medicinal plants; oxidative stress and bioactivity of plant extracts and products; toxicology
Interests: natural products; antioxidants; bioactivity; biochemistry; microbiology; industrial biotechnology
Interests: natural product chemistry; medicinal plants; oxidative stress; bioactivity of plant extracts and phytochemical analysis; toxicology
Using plant bioactive compounds to prevent, treat and cure diseases is an ancient medicinal practice. This type of treatment is extremely important, especially for developing countries, where medicinal plants are used in their raw form, such as in teas and herbal medicines, as alternatives to allopathic medicinal products for primary health care. Estimates indicate that approximately 40% of currently marketed drugs are developed directly or indirectly from natural sources, of which 25% are of plant origin. Plants produce secondary metabolites of unprecedented structural diversity, providing valuable clues to the discovery of new, often safer, drugs. The extraction, characterization, encapsulation and pharmacological potential of plants are attracting increasing attention in the fields of pharmaceuticals, food, medicine, nutrition and biotechnology.
This Special Issue, “Plant Bioactive Compounds: Extraction, Encapsulation, Characterization and Pharmacological Potential”, aims to highlight the latest developments and emerging trends in research on medicinal plants and their potential therapeutic value. We invite researchers from around the world to submit full original research articles as well as review articles sharing their latest findings and ideas in this exciting field of science.
Dr. Maria das Graças Almeida
Dr. Jorge A. López
Dr. Jefferson Romáryo Duarte Da Luz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- plant natural compounds
- plant extracts
- characterization of bioactive natural compounds
- encapsulation of plant extracts and isolated plant compounds
- pharmacological potential
- biological properties
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: In Vitro Antithrombotic, Antitumor and Anti-angiogenic Activities of Green Tea Polyphenols and its Main Constituent Epigallocatechin-3-gallate
Authors: Maria das Graças Almeida
Affiliation: Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil
Abstract: The balance between embolic risk and bleeding is a clinical challenge in cancer patient treatment, which stimulates studies on adjuvant oncologic treatments. Thereby, this study evaluated the in vitro effect of green tea extract (GTE) and epigallocatechin-3-gallate (EGCG) on hemostasis modulation, and the antineoplastic effect in melanoma cells (B16-F10) through platelet aggregation, angiogenesis and viability cell assays. Results showed a significant platelet antiaggregant effect, corresponding to 50 and 80% for extract and EGCG, respectively, compared to the negative control. Furthermore, both GTE and EGCG exhibited antitumor effects by reducing in 25 and 50% the melanoma growth cells, respectively, verified by cellular apoptosis. Regarding angiogenesis, these substances inhibited blood vessel formation, reaching about 25% with GTE and 99% with EGCG at high concentrations. Moreover, the cell stimulation with TNF-α evidenced the VEGF and IL-8 secretion inhibition at 55 and 20% in the presence of GTE, while the inhibition caused by EGCG was around 78% for both VEGF and IL-8. Although more studies are required regarding the action mechanism of these products on clotting, cell death, and angiogenesis, results with GTE and EGCG are promising as an option for cancer treatment and its side effects.