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Special Issue "Antimicrobial Compounds from Alternative Sources 2.0"
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: 31 October 2023 | Viewed by 2223
Special Issue Editors
Interests: antibiotic resistance; anthelminthic resistance in ruminants; virus infection
Special Issues, Collections and Topics in MDPI journals
Special Issue in Antibiotics: Natural Antimicrobials from Bee Products: Biological Activities and Future Perspectives
Special Issue in Antibiotics: Antimicrobial Resistance and Zoonoses
Special Issue in Microorganisms: Antibiotic Resistance in Isolates from Diseased and Healthy Livestock
Special Issue in Microorganisms: Antimicrobial Resistance in Heavy Metal Polluted Areas
Interests: molecular medicine;antimicrobial resistance; cytotoxicity; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
This Special Issue is a continuation of our previous Special Issue, “Antimicrobial Compounds from Alternative Sources”.
Antimicrobial therapy revolutionized both human and veterinary medicine, leading to a spectacular decrease in infection rates and a dramatic reduction in epidemics. Diseases such as tuberculosis found their “therapeutic golden standard” when streptomycin was discovered in 1944. Numerous antibiotic groups were subsequently discovered, such as tetracycline (1945), rifamycin (1957), quinolones and streptogramins (1962), cephalexin (1968), carbapenem (1976), norfloxacin (1986), linezolid (1989), and others.
Nevertheless, if one looks into the efficacy of these drugs, many of which are also approved for veterinary or human use, it is obvious that resistance develops soon after their introduction in therapy. Thus, only five years after the introduction of penicillin, the first resistant strain of S. aureus was identified. Similarly, only three years (or one, according to other authors) elapsed between the introduction of erythromycin and linezolid in humans and reports of resistance to these drugs. Additionally, an increasing number of bacterial strains, some pathogenic and some ubiquitous, have been reported to acquire multiple resistance to antibiotics, further complicating the therapeutic approach in both human and animal patients.
Such laboratory and clinical research results led WHO and OIE to consider antibiotic resistance “one of the biggest threats to global health, food security, and development today”. Bacteria, pathogenic or epiphytic, gain their antibiotic resistance under natural circumstances. Nevertheless, the changes that occur in the resistome are accelerated and broadened by either misuse or inappropriate/exaggerated treatment with antimicrobials in both humans and animals. The subsequent pollution of the surrounding habitats/broader environment with resistance genes and also poor infection prevention and control may pose risks for humans, livestock, and wildlife. The “ESKAPE” group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species) represents one of the best examples of the threat to “one health”. Since new antibiotic resistance mechanisms are continuously developed by bacteria, we cannot expect that antibiotics yet to be synthesized will cope with multiresistant microbial strains in the post-antibiotic era.
Nature has been very generous in providing humankind with numerous resources for its survival and fight against diseases. Medicinal and aromatic plants have represented the center of traditional therapeutic practices for millennia, being cited in the oldest written evidence for their healing power. Nonetheless, modern science relies on traditional preparations, as extracts from these plants are difficult to standardize. Therefore, combinations of plant extracts and allopathic drugs, due to their synergistic effects, have been suggested. Bee products have numerous proven health-directed properties, including antimicrobial ones mainly allocated to propolis and Manuka honey. Numerous other marine and terrestrial organisms, along the entire phylogenetic scale, have also been mentioned as a source of antimicrobials by researchers. Finally, other natural mineral compounds, such as clay or coal, lignite, or zeolites, have been tested and found to be efficient antimicrobials, directly or indirectly, due to their diverse properties.
This Special Issue aims at providing an updated overview of research results for alternative sources of antimicrobial drugs and therapies, their laboratory or clinical use, preparation technologies, factors influencing their efficacy in medicine, and their impact on preserving “One Health” and “”One Welfare”. Submissions of perspectives, opinions, commentaries, and data reports are also welcome.
Potential topics include, but are not limited to, the following:
- Antimicrobial compounds from plants: their preparation, use, and biological effects;
- Bee products: their role in obtaining novel antimicrobials;
- Antimicrobial compounds from mineral sources: obtainment methodology, standardization, and biological effects;
- Antimicrobials from other sources (marine or terrestrial, microorganisms, etc.): obtainment methodology, effects, and biological uses;
- Impact of alternative antimicrobials on antibiotic resistance gene transfer;
- Farming technologies and alternative antibiotic uses;
- Potential role of alternative antimicrobial in controlling environment pollution;
- Prevention and control of antibiotic resistance by use of alternative antimicrobials.
Dr. Marina Spinu
Dr. Pall Emoke
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antimicrobial compounds from plants: their preparation, use, and biological effects
- bee products: their role in obtaining novel antimicrobials
- antimicrobial compounds from mineral sources: obtainment methodology, standardization, biological effects
- antimicrobials from other sources (marine or terrestrial, microorganisms, etc.): obtainment methodology, effects, biological uses
- impact of alternative antimicrobials on antibiotic resistance gene transfer
- farming technologies and alternative antibiotic uses
- potential role of alternative antimicrobial to control environment pollution
- prevention and control of antibiotic resistance by use of alternative antimicrobials