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Microorganisms
Special Issues
Microbiota and Aging
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Microbiota and Aging

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4631

Special Issue Editors

Prof. Dr. Mark Obrenovich

E-Mail Website
Guest Editor
Institute of Pathology and Department of Chemistry, Case Western Reserve University (CWRU), Cleveland, OH 44106, USA
Interests: infectious disease; clinical diagnostics; in vitro; cancer detection; molecular biology; small molecule metabolomics; synbiotics; clinical chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Ravichandra Vemuri

E-Mail Website
Guest Editor
Wake Forest School for Medicine, Comparative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC 27101, USA
Interests: microbiome; metabolism; probiotics; aging; hypertension
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Evidence now suggests the occurrence of age-related changes in both the diversity and quality of our gut microbiota, and these changes can affect the healthy aging process in animal models. Moreover, age-related microbial diversity changes are associated with increased frailty and reduced cognitive performance. These findings suggest that the microbiota–gut–brain axis is affected in age-related diseases and the underlying pathogenesis. This Special Issue focuses on aspects of the aging gut and interventions aimed at addressing aging though the gut microbiota and the associated co-metabolism that ensues. 

We look forward to receiving your contributions.

Prof. Dr. Mark Obrenovich
Dr. Ravichandra Vemuri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • microbiota
  • microbiota–gut–brain axis
  • polyphenolic derivatives
  • small phenolic acid molecules
  • fecal transplant
  • cognitive function
  • mice
  • oxidative stress and immunity

Published Papers (2 papers)

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Research

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18 pages, 4424 KiB  
Article
Multi-Omics Analysis Reveals Age-Related Microbial and Metabolite Alterations in Non-Human Primates
by Xiang Chen, Yiyun Liu, Juncai Pu, Siwen Gui, Dongfang Wang, Xiaogang Zhong, Wei Tao, Xiaopeng Chen, Weiyi Chen, Yue Chen, Renjie Qiao and Peng Xie
Microorganisms 2023, 11(10), 2406; https://doi.org/10.3390/microorganisms11102406 - 26 Sep 2023
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Abstract
Aging is a systemic physiological degenerative process, with alterations in gut microbiota and host metabolism. However, due to the interference of multiple confounding factors, aging-associated molecular characteristics have not been elucidated completely. Therefore, based on 16S ribosomal RNA (rRNA) gene sequencing and non-targeted [...] Read more.
Aging is a systemic physiological degenerative process, with alterations in gut microbiota and host metabolism. However, due to the interference of multiple confounding factors, aging-associated molecular characteristics have not been elucidated completely. Therefore, based on 16S ribosomal RNA (rRNA) gene sequencing and non-targeted metabolomic detection, our study systematically analyzed the composition and function of the gut microbiome, serum, and fecal metabolome of 36 male rhesus monkeys spanning from 3 to 26 years old, which completely covers juvenile, adult, and old stages. We observed significant correlations between 41 gut genera and age. Moreover, 86 fecal and 49 serum metabolites exhibited significant age-related correlations, primarily categorized into lipids and lipid-like molecules, organic oxygen compounds, organic acids and derivatives, and organoheterocyclic compounds. Further results suggested that aging is associated with significant downregulation of various amino acids constituting proteins, elevation of lipids, particularly saturated fatty acids, and steroids. Additionally, age-dependent changes were observed in multiple immune-regulatory molecules, antioxidant stress metabolites, and neurotransmitters. Notably, multiple age-dependent genera showed strong correlations in these changes. Together, our results provided new evidence for changing characteristics of gut microbes and host metabolism during aging. However, more research is needed in the future to verify our findings. Full article
(This article belongs to the Special Issue Microbiota and Aging)
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Review

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13 pages, 928 KiB  
Review
Beyond the Gut, Emerging Microbiome Areas of Research: A Focus on Early-Life Microbial Colonization
by Ravichandra Vemuri and Manoja P. Herath
Microorganisms 2023, 11(2), 239; https://doi.org/10.3390/microorganisms11020239 - 18 Jan 2023
Cited by 3 | Viewed by 2714
Abstract
Undoubtedly, the human body harbors trillions of microbes of different kinds performing various physiological activities, such as priming the immune system, influencing host metabolism, and improving health by providing important metabolites such as short-chain fatty acids. Although the gut is considered the “microbial [...] Read more.
Undoubtedly, the human body harbors trillions of microbes of different kinds performing various physiological activities, such as priming the immune system, influencing host metabolism, and improving health by providing important metabolites such as short-chain fatty acids. Although the gut is considered the “microbial organ” of our body as it hosts the most microbes, there are microbes present in various other important anatomical locations differing in numbers and type. Research has shown the presence of microbes in utero, sparking a debate on the “sterile womb” concept, and there is much scope for more work in this area. It is important to understand the early-life microbiome colonization, which has a role in the developmental origins of health and disease in later life. Moreover, seminal studies have indicated the presence of microbes beyond the gut, for example, in the adipose tissue and the liver. However, it is still unclear what is the exact source of these microbes and their exact roles in health and disease. In this review, we appraise and discuss emerging microbiome areas of research and their roles in metabolic health. Further, we review the importance of the genital microbiome in early-life microbial interactions. Full article
(This article belongs to the Special Issue Microbiota and Aging)
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