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Micro
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Microenvironment and Nanocarriers
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Microenvironment and Nanocarriers

A special issue of Micro (ISSN 2673-8023). This special issue belongs to the section "Microscale Biology and Medicines".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3891

Special Issue Editor

Dr. Horacio Bach

E-Mail Website
Guest Editor
Faculty of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC V6T 1Z, Canada
Interests: infectious diseases; microbiology; nano medicine; host-pathogen interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The microenvironment of tumors contains various types of cells essential for homeostasis, support, and tumor development. Tumor microenvironments are characterized by unique physiologic features that are attractive for their precise targeting. For instance, the tumor metabolism can change the pH of the environment to a more acidic value, reduce the oxygen tension (hypoxia), or elevate the production of reactive oxygen species.

Enhanced permeability and retention are a phenomenon by which specific sizes of particles accumulate within the tumor to a higher degree than normal tissues. This accumulation offers a plethora of possibilities to sequester nanocarriers develop for delivery and targeting this compartment.

In this Special Edition of Microenvironment and Nanocarriers, original studies or reviews are welcome. 

Dr. Horacio Bach
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micro is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer cell targeting
  • drug delivery
  • imaging
  • microenvironment modification
  • nanocarriers distribution
  • nanocarriers types
  • nanotherapeutics
  • theranostics

Published Papers (2 papers)

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Research

11 pages, 2265 KiB  
Article
Assessment of Pharmaco-Technological Parameters of Solid Lipid Nanoparticles as Carriers for Sinapic Acid
by Stefano Russo, Giuliana Greco and Maria Grazia Sarpietro
Micro 2023, 3(2), 510-520; https://doi.org/10.3390/micro3020034 - 05 May 2023
Viewed by 1342
Abstract
Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic acid, belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim of this work was to incorporate sinapic acid into solid lipid nanoparticles in order to improve its [...] Read more.
Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic acid, belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim of this work was to incorporate sinapic acid into solid lipid nanoparticles in order to improve its bioavailability. SLNs were prepared using the hot high-speed homogenization method. The pharmaco-technological properties and thermotropic profile of SLNs encapsulated with sinapic acid, as well as their interaction with biomembrane models, were evaluated. SLNs showed promising physicochemical properties and encapsulation efficiency, as well as a desirable release profile; moreover, they facilitated the interaction of sinapic acid with a biomembrane model made of multilamellar vesicles. In conclusion, this formulation can be used in further studies to assess its suitability to improve sinapic acid activity. Full article
(This article belongs to the Special Issue Microenvironment and Nanocarriers)
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9 pages, 1443 KiB  
Communication
Synthesis, Characterization, and Acute Cytotoxicity Evaluation of Chloroquine Encapsulating Liposomes
by Nathan D. Donahue, Ellen A. Vance, Vinit Sheth, Emmy R. Francek and Stefan Wilhelm
Micro 2023, 3(1), 51-59; https://doi.org/10.3390/micro3010005 - 13 Jan 2023
Cited by 1 | Viewed by 1961
Abstract
Liposomes encapsulating chloroquine were synthesized and characterized. Cryogenic transmission electron microscopy and dynamic light scattering confirmed a liposome size of ~100 nm and uniform shape. Two independent analytical methods were used to quantify chloroquine encapsulation: (i) HPLC, and (ii) UV-Vis spectrophotometry. Using RAW264.7 [...] Read more.
Liposomes encapsulating chloroquine were synthesized and characterized. Cryogenic transmission electron microscopy and dynamic light scattering confirmed a liposome size of ~100 nm and uniform shape. Two independent analytical methods were used to quantify chloroquine encapsulation: (i) HPLC, and (ii) UV-Vis spectrophotometry. Using RAW264.7 murine macrophages as model immune cells, cell culture experiments revealed an improved acute cytotoxicity profile of chloroquine encapsulating liposomes with >90% cell viability compared to free chloroquine (cell viability ~30%) at equivalent drug doses. These results may potentially be relevant for liposome-based chloroquine delivery for nanomedicine applications. Full article
(This article belongs to the Special Issue Microenvironment and Nanocarriers)
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