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Metabolites
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Advances in Lipid Metabolism and Skin Health
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Advances in Lipid Metabolism and Skin Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 10396

Special Issue Editors

Prof. Dr. Elz̀bieta Skrzydlewska

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Medical Univesrity of Białystok, Bialystok, Poland
Interests: oxidative stress and its consequences in various pathological conditions in humans (tick diseases, RA, skin diseases, cancer, hypertension); animal models and cell cultures; modification of the structure and function of phospholipids metabolites; proteins involved in metabolic processes
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Neven Zarkovic

E-Mail Website
Guest Editor
Institute Ruder Boskovic, Zagreb, Croatia
Interests: multidisciplinary areas of molecular medicine and life sciences; focused and stress and age-associated diseases; pathophysiology of lipid peroxidation as common fundamental processes of cancer; inflammation and degenerative processes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pathophysiology of various skin diseases is associated with occurrence of chronic inflammation and oxidative stress, the consequence of which are metabolic changes, including lipid metabolism. Metabolic disorders are also consequence of exogenous physical factors (e.g. UV radiation) and chemical factors (drugs, cosmetics, etc.) acting on the skin. Therefore, increasing attention is paid to lipid metabolism dependent on both reactive oxygen species and enzymes in the cells of dermis and epidermis.

These metabolic modifications are accompanied by changes at the level of lipid mediators involved in signaling at the (sub)cellular level and at the level of entire organ (skin). Consequently, metabolic changes may also occur at the level of entire organism. Hence, the assessment of lipid metabolism, including their metabolic functions and individual metabolites, both in the physiology and pathology of various diseases is very important. Rapid development of analytical tools for metabolomic-lipidomic research in the last decade, such as platforms for separation techniques combined with mass spectrometry and new chemometric methodologies, along with advanced immunochemical methods, has favored much more accurate lipidome assessment to study metabolic alterations.

The purpose of this special edition is to present the results of original research or review papers on important pathophysiological changes in the skin lipidome associated with the development of skin diseases, as well as systemic stress response and response of cells to physicochemical factors implemented by translations studies that can help development of integrative biomedical diagnostics and treatment of lipid disorders.

Prof. Dr. Elzbieta Skrzydlewska
Prof. Dr. Neven Zarkovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • keratinocytes
  • fibroblasts
  • lipid metabolism
  • lipid peroxidation
  • lipid mediators
  • lipidomics
  • lipid biomarkers of diseases
  • pharmacotherapy

Published Papers (4 papers)

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Research

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11 pages, 937 KiB  
Article
GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types
by Ting Bu, Ming Zhang, Sun-Hee Lee, Yu Eun Cheong, Yukyung Park, Kyoung Heon Kim, Dongwon Kim and Sooah Kim
Metabolites 2022, 12(8), 717; https://doi.org/10.3390/metabo12080717 - 03 Aug 2022
Cited by 2 | Viewed by 1546
Abstract
Skin has heterogenous identities on different body sites despite similar cellular compositions. There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these [...] Read more.
Skin has heterogenous identities on different body sites despite similar cellular compositions. There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatography-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics analysis revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiological characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. Full article
(This article belongs to the Special Issue Advances in Lipid Metabolism and Skin Health)
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13 pages, 3326 KiB  
Article
The Linoleic Acid Content of the Stratum Corneum of Ichthyotic Golden Retriever Dogs Is Reduced as Compared to Healthy Dogs and a Significant Part Is Oxidized in Both Free and Esterified Forms
by Iuliana Popa, Audrey Solgadi, Didier Pin, Adrian L. Watson, Marek Haftek and Jacques Portoukalian
Metabolites 2021, 11(12), 803; https://doi.org/10.3390/metabo11120803 - 26 Nov 2021
Cited by 3 | Viewed by 1487
Abstract
Golden Retrievers may suffer from Pnpl1-related inherited ichthyosis. Our study shows that in the stratum corneum (SC) of ichthyotic dogs, linoleic acid (LA) is also present in the form of 9-keto-octadecadienoic acid (9-KODE) instead of the acylacid form as in normal dogs. [...] Read more.
Golden Retrievers may suffer from Pnpl1-related inherited ichthyosis. Our study shows that in the stratum corneum (SC) of ichthyotic dogs, linoleic acid (LA) is also present in the form of 9-keto-octadecadienoic acid (9-KODE) instead of the acylacid form as in normal dogs. The fatty acids purified from SC strips (LA, acylacids) were characterized by liquid chromatography-tandem mass spectrometry (LC-MS) and atmospheric pressure chemical ionization (APCI). Electrospray ionization (ESI) and MS2(MS/MS Tandem mass spectrum/spectra)/M3 (MS/MS/MS Tandem mass spectrum/spectra) fragmentation indicated the positions of the double bonds in 9-KODE. We showed that ichthyotic dogs have a threefold lower LA content in the form of acylacids. The MS2 fragmentation of acyl acids showed in some peaks the presenceof an ion at the m/z 279, instead of an ion at m/z 293 which is characteristic of LA. The detected variant was identified upon MS3 fragmentation as 9-keto-octadecadienoic acid (9-KODE), and the level of this keto-derivative was increased in ichthyotic dogs. We showed by the APCI that such keto forms of LA are produced from hydroperoxy-octadecadienoic acids (HpODE) upon dehydration. In conclusion, the free form of 9-KODE was detected in ichthyotic SC up to fivefold as compared to unaffected dogs, and analyses by HPLC (High performance liquid chromatography) and ESI-MS (Electrospray Ionization-Mass Spectrometry) indicated its production via dehydration of native 9-HpODE. Full article
(This article belongs to the Special Issue Advances in Lipid Metabolism and Skin Health)
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20 pages, 8883 KiB  
Article
Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis
by Jackeline Franco, Bartek Rajwa, Paulo Gomes and Harm HogenEsch
Metabolites 2021, 11(10), 670; https://doi.org/10.3390/metabo11100670 - 30 Sep 2021
Cited by 6 | Viewed by 2484
Abstract
Lipids play a critical role in the skin as components of the epidermal barrier and as signaling and antimicrobial molecules. Atopic dermatitis in dogs is associated with changes in the lipid composition of the skin, but whether these precede or follow the onset [...] Read more.
Lipids play a critical role in the skin as components of the epidermal barrier and as signaling and antimicrobial molecules. Atopic dermatitis in dogs is associated with changes in the lipid composition of the skin, but whether these precede or follow the onset of dermatitis is unclear. We applied rapid lipid-profiling mass spectrometry to skin and blood of 30 control and 30 atopic dogs. Marked differences in lipid profiles were observed between control, nonlesional, and lesional skin. The lipid composition of blood from control and atopic dogs was different, indicating systemic changes in lipid metabolism. Female and male dogs differed in the degree of changes in the skin and blood lipid profiles. Treatment with oclacitinib or lokivetmab ameliorated the skin condition and caused changes in skin and blood lipids. A set of lipid features of the skin was selected as a biomarker that classified samples as control or atopic dermatitis with 95% accuracy, whereas blood lipids discriminated between control and atopic dogs with 90% accuracy. These data suggest that canine atopic dermatitis is a systemic disease and support the use of rapid lipid profiling to identify novel biomarkers. Full article
(This article belongs to the Special Issue Advances in Lipid Metabolism and Skin Health)
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Review

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20 pages, 973 KiB  
Review
Algal Lipids as Modulators of Skin Disease: A Critical Review
by Tiago Conde, Diana Lopes, Wojciech Łuczaj, Bruno Neves, Bruno Pinto, Tatiana Maurício, Pedro Domingues, Elżbieta Skrzydlewska and M. Rosário Domingues
Metabolites 2022, 12(2), 96; https://doi.org/10.3390/metabo12020096 - 20 Jan 2022
Cited by 19 | Viewed by 3911
Abstract
The prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The [...] Read more.
The prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The pathophysiology of inflammatory skin diseases such as psoriasis or atopic dermatitis, but also of skin cancers, is the result of the activation of inflammation-related metabolic pathways and the overproduction of pro-inflammatory cytokines observed in in vitro and in vivo studies. Inflammatory skin diseases are also associated with oxidative stress, overproduction of ROS, and impaired antioxidant defense, which affects the metabolism of immune cells and skin cells (keratinocytes and fibroblasts) in systemic and skin disorders. Lipids from algae have been scarcely applied to modulate skin diseases, but they are well known antioxidant and anti-inflammatory agents. They have shown scavenging activities and can modulate redox homeostasis enzymes. They can also downmodulate key inflammatory signaling pathways and transcription factors such as NF-κB, decreasing the expression of pro-inflammatory mediators. Thus, the exploitation of algae lipids as therapeutical agents for the treatment of inflammatory skin diseases is highly attractive, being critically reviewed in the present work. Full article
(This article belongs to the Special Issue Advances in Lipid Metabolism and Skin Health)
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