Impact of Foods and Bioactive Compounds on Metabolic Profile

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Food Metabolomics".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 1375

Special Issue Editors


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Guest Editor
1. Departamento de Engenharia Química, Instituto Superior de Engenharia de Lisboa (ISEL), R. Conselheiro Emídio Navarro 1, 1959-007 Lisboa, Portugal
2. Centro de Química Estrutural, Institute of Molecular Sciences, Universidade de Lisboa, 1749-016 Lisboa, Portugal
Interests: bioactive compounds; phenolic compounds; natural compounds; metabolomics; mass spectrometry; biochemistry; biocatalysis, extraction and separation processes; bioinformatics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Departamento de Engenharia Química, Instituto Superior de Engenharia de Lisboa (ISEL), R. Conselheiro Emídio Navarro 1, 1959-007 Lisboa, Portugal
2. Unidade de Geobiociências, Geoengenharias e Geotecnologias, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Monte de Caparica, 2829-516 Caparica, Portugal
Interests: fungi; microalgae; coffee leaves and beans; bioactive compounds; proteomics; HPLC-MS; monoclonal antibodies

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit an original research article, review, or perspective paper for this Special Issue.

Understanding the impact of food and its associated bioactive compounds in a system metabolic profile is crucial for improving human health, preventing diseases, developing personalized dietary recommendations, and/or identifying novel therapeutic targets for diseases and metabolic disorders.

The intake of nutrients and bioactive compounds or a complex mixture of these in food matrices can have profound effects on metabolism; therefore, in recent years, several studies have been conducted which focused on this topic. However, due to the complexity and multifaceted nature of the interactions and effects of food and its bioactive compounds, it is important to broaden our understanding of this subject.

Metabolic profiling or metabolomics is a rapidly growing field of research, mostly due to progress in the field due to the development of several state-of-the-art analytical techniques. Therefore, this Special Issue is dedicated to the report of recent advances in systems dynamics and metabolic changes, both in vitro and/or in vivo, using metabolic approaches, aiming to rationalize the complex relationships between diet, metabolism, health, and disease. 

Dr. Rita Pacheco
Dr. Sónia Martins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food
  • bioactive compounds
  • metabolic profiling
  • metabolomics
  • health
  • disease
  • diet
  • dietary intake
  • biomarkers
  • foodomics

Published Papers (1 paper)

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Research

14 pages, 1622 KiB  
Article
Influence of Symbiotic Fermentation Broth on Regulating Metabolism with Gut Microbiota and Metabolite Profiles Is Estimated Using a Third-Generation Sequencing Platform
by Chih-Yin Wu, Chun-Kai Huang, Wei-Sheng Hong, Yin-Hsiu Liu, Ming-Chi Shih and Jung-Chun Lin
Metabolites 2023, 13(9), 999; https://doi.org/10.3390/metabo13090999 - 08 Sep 2023
Viewed by 757
Abstract
Overnutrition with a high-fat or high-sugar diet is widely considered to be the risk factor for various metabolic, chronic, or malignant diseases that are accompanied by alterations in gut microbiota, metabolites, and downstream pathways. In this study, we investigated supplementation with soybean fermentation [...] Read more.
Overnutrition with a high-fat or high-sugar diet is widely considered to be the risk factor for various metabolic, chronic, or malignant diseases that are accompanied by alterations in gut microbiota, metabolites, and downstream pathways. In this study, we investigated supplementation with soybean fermentation broth containing saponin (SFBS, also called SAPOZYME) in male C57BL/6 mice fed a high-fat-fructose diet or normal chaw. In addition to the lessening of weight gain, the influence of SFBS on reducing hyperlipidemia and hyperglycemia associated with a high-fat-fructose diet was estimated using the results of related biological tests. The results of gut microbial profiling indicated that the high-fat-fructose diet mediated increases in opportunistic pathogens. In contrast, SFBS supplementation reprogrammed the high-fat-fructose diet-related microbial community with a relatively high abundance of potential probiotics, including Akkermansia and Lactobacillus genera. The metagenomic functions of differential microbial composition in a mouse model and enrolled participants were assessed using the PICRUSt2 algorithm coupled with the MetaCyc and the KEGG Orthology databases. SFBS supplementation exerted a similar influence on an increase in the level of 4-aminobutanoate (also called GABA) through the L-glutamate degradation pathway in the mouse model and the enrolled healthy population. These results suggest the beneficial influence of SFBS supplementation on metabolic disorders associated with a high-fat-fructose diet, and SFBS may function as a nutritional supplement for people with diverse requirements. Full article
(This article belongs to the Special Issue Impact of Foods and Bioactive Compounds on Metabolic Profile)
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