Metabolomics in Disease Mechanisms and Drug Targets
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".
Deadline for manuscript submissions: 15 July 2024 | Viewed by 2010
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metabolomics, a distinct and comprehensive top–down methodology, offers profound insights into intricate systems, with its profiles encapsulating the phenotypic manifestations of cellular reactions to physiological, pathophysiological stimuli, and epigenetic alterations. Through quantitative profiling of the metabolome, we can glean mechanistic insights into a myriad of biological functions and processes. Recent advancements in metabolomic analysis have propelled us towards a fresh understanding of the intricate mechanisms underlying complex metabolic diseases. Furthermore, metabolomics can illuminate potential new targets for therapeutic intervention by pinpointing pathological metabolic shifts, particularly those involving enzymes that exhibit increased flux during disease progression. The successful clinical development of therapies targeting these novel entities has heightened interest and appreciation of the value of metabolomics as a strategy for drug target identification. However, numerous challenges remain to be addressed, including understanding the connectivity and interactions among metabolites, elucidating complex disease mechanisms, and pinpointing appropriate drug targets.
In light of these considerations, this Special Issue is dedicated to the exploration of metabolomics in the context of disease mechanisms and drug target identification. We invite original research articles and comprehensive reviews that illuminate the role of metabolomics in disease mechanism elucidation and drug target discovery, with a particular focus on innovative strategies and methodologies to overcome existing challenges.
Dr. Kefeng Li
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolomics
- disease mechanism
- drug target
- biomarker
- disease prediction
