Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1428

Special Issue Editor

Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China
Interests: nutrition; functional foods; amino acid peptides; structure–activity relationship; peptide absorption

Special Issue Information

Dear Colleagues,

Bioactive peptides have been associated with various health benefits, including antioxidant, anti-inflammatory, antihypertensive, and immunomodulatory effects. Understanding how these peptides are absorbed by the body can provide insights into their potential to prevent and manage chronic diseases such as cardiovascular diseases, diabetes and others. It can further help in optimizing food processing methods to enhance the availability of these beneficial compounds in the final food products. This can lead to the development of functional foods that offer targeted health benefits, contributing to improved overall public health.

This Special Issue of Metabolites will publish reviews and original articles covering the latest developments in metabolic absorption of bioactive peptides. We welcome research on topics related, but not limited, to the following: molecular and cellular mechanisms facilitating the absorption of bioactive peptides within the human body, the structure–function relationships of bioactive peptides and their absorption in the gastrointestinal tract, investigations on the metabolic pathways and metabolites of peptide molecules within the body and the physiological effects and mechanisms of action of these bioactive peptides. Through a comprehensive exploration of these research areas, we aim to provide a deeper understanding of the interactions between bioactive peptides and the human body, expand the knowledge of the relationship between food and health and contribute to the advancement of the food industry.

Dr. Boqun Liu
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • peptide
  • absorption
  • metabolism
  • structure–function relationships
  • metabolic pathways

Published Papers (1 paper)

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15 pages, 4227 KiB  
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells
by Peizhi Li, Xibi Fang, Guijie Hao, Xiaohui Li, Yue Cai, Yuhao Yan, Liting Zan, Runjun Yang and Boqun Liu
Metabolites 2023, 13(11), 1149; - 14 Nov 2023
Viewed by 1223
Breast milk is widely considered to be the most natural, safe, and complete food for infants. However, current breastfeeding rates fall short of the recommendations established by the World Health Organization. Despite this, there are few studies that have focused on the promotion [...] Read more.
Breast milk is widely considered to be the most natural, safe, and complete food for infants. However, current breastfeeding rates fall short of the recommendations established by the World Health Organization. Despite this, there are few studies that have focused on the promotion of human lactation through nutrient supplementation. Therefore, the aim of this study was to investigate the effect of methionine on milk synthesis in human mammary epithelial cells (MCF-10A cells) and to explore the underlying mechanisms. To achieve this, MCF-10A cells were cultured with varying concentrations of methionine, ranging from 0 to 1.2 mM. Our results indicated that 0.6 mM of methionine significantly promoted the synthesis of milk protein. An RNA-seq analysis revealed that methionine acted through the PI3K pathway. This finding was validated through real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting. In addition, PI3K inhibition assays confirmed that methionine upregulated the expression of both mTOR and p-mTOR through activation of PI3K. Taken together, these findings suggest that methionine positively regulates milk protein synthesis in MCF-10A cells through the PI3K-mTOR signaling pathway. Full article
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