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Metabolites
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Hemorheology and Metabolism Volume II
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Hemorheology and Metabolism Volume II

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 9537

Special Issue Editor

Prof. Dr. Norbert Nemeth

E-Mail Website
Guest Editor
Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary
Interests: hemorheology; microcirculation; surgical research; microsurgery; ischemia-reperfusion; sepsis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a pleasure to invite you to submit a review or a research article for publication in the Special Issue ‘Hemorheology and Metabolism’ Volume II for the journal Metabolites (MDPI).

Hemorheology deals with macro- and micro-dimensions of blood flow properties, its cellular and plasmatic factors, and the vessel wall with which the flowing blood comes into direct contact. In this sense, hemorheology plays an important role in determining the characteristics of blood flow, the tissue perfusion, microcirculation and the shear-stress-related endothelial functions in health and disease. In the past decades clinical and experimental studies revealed that micro-rheological parameters, such as red blood cell deformability and aggregation, are influenced by numerous factors, including metabolic ones. However, several questions remained unanswered related to the magnitude and dynamics of changes, border of reversibility/irreversibility, pathophysiology, as well as preventive and therapeutic issues. Thanking to the modern investigative methods a new insight have been provided into the relation of blood rheology and metabolites. This relation has a significance in cardiovascular and metabolic disorders, in inflammatory processes, including sepsis and ischemia-reperfusion, in intensive therapy, sports medicine, as well as in exercise and comparative physiology.

This Special Issue is dedicated to the novel findings and recent advances in this field. Clinical or clinically oriented experimental research, or review articles in the context of metabolites/metabolic alterations and blood macro- and micro-rheology will be welcome.

Prof. Dr. Norbert Nemeth
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hemorheology
  • microcirculation
  • metabolites
  • metabolic disorders
  • in vitro and in vivo effects

Related Special Issue

Published Papers (6 papers)

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Research

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14 pages, 642 KiB  
Article
Effects of a Maximal Exercise Followed by a Submaximal Exercise Performed in Normobaric Hypoxia (2500 m), on Blood Rheology, Red Blood Cell Senescence, and Coagulation in Well-Trained Cyclists
by Romain Carin, Gabriel Deglicourt, Hamdi Rezigue, Marie Martin, Christophe Nougier, Camille Boisson, Yesim Dargaud, Philippe Joly, Céline Renoux, Philippe Connes, Emeric Stauffer and Elie Nader
Metabolites 2023, 13(2), 179; https://doi.org/10.3390/metabo13020179 - 25 Jan 2023
Cited by 2 | Viewed by 1352
Abstract
Acute normoxic exercise impacts the rheological properties of red blood cells (RBC) and their senescence state; however, there is a lack of data on the effects of exercise performed in hypoxia on RBC properties. This crossover study compared the effects of acute hypoxia [...] Read more.
Acute normoxic exercise impacts the rheological properties of red blood cells (RBC) and their senescence state; however, there is a lack of data on the effects of exercise performed in hypoxia on RBC properties. This crossover study compared the effects of acute hypoxia vs. normoxia on blood rheology, RBC senescence, and coagulation during exercise. Nine trained male cyclists completed both a session in normoxia (FiO2 = 21%) and hypoxia (FiO2 = 15.3% ≈ 2500 m). The two sessions were randomly performed, separated by one week, and consisted of an incremental and maximal exercise followed by a 20 min exercise at the first ventilatory threshold (VT1) on a home-trainer. Blood samples were taken before and after exercise to analyze hematological parameters, blood rheology (hematocrit, blood viscosity, RBC deformability and aggregation), RBC senescence markers (phosphatidylserine (PS) and CD47 exposure, intraerythrocyte reactive oxygen species (ROS), and calcium content), and blood clot viscoelastic properties. Hemoglobin oxygen saturation (SpO2) and blood lactate were also measured. In both conditions, exercise induced an increase in blood viscosity, hematocrit, intraerythrocyte calcium and ROS content, and blood lactate concentration. We also observed an increase in blood clot amplitude, and a significant drop in SpO2 during exercise in the two conditions. RBC aggregation and CD47 exposure were not modified. Exercise in hypoxia induced a slight decrease in RBC deformability which could be related to the slight increase in mean corpuscular hemoglobin concentration (MCHC). However, the values of RBC deformability and MCHC after the exercise performed in hypoxia remained in the normal range of values. In conclusion, acute hypoxia does not amplify the RBC and coagulation changes induced by an exercise bout. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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11 pages, 1372 KiB  
Article
Walking Exercise Reduces Postprandial Lipemia but Does Not Influence Postprandial Hemorheological Properties and Oxidative Stress
by Ching-Lin Wu, Tsung-Jen Yang, Min-Huan Wu, Hong-Jen Liang, Yi-Liang Chen, Shey-Lin Wu and Chih-Hui Chiu
Metabolites 2022, 12(11), 1038; https://doi.org/10.3390/metabo12111038 - 28 Oct 2022
Cited by 1 | Viewed by 1294
Abstract
A higher postprandial triglycerides response and hemorheological abnormalities may increase the incidence of metabolic disorders and negatively interfere with the aging process. A single session of preprandial endurance exercise was found to be effective in reducing triglyceride levels after a high-fat diet. However, [...] Read more.
A higher postprandial triglycerides response and hemorheological abnormalities may increase the incidence of metabolic disorders and negatively interfere with the aging process. A single session of preprandial endurance exercise was found to be effective in reducing triglyceride levels after a high-fat diet. However, whether the exercise-induced reduction in postprandial triglyceride levels influences hemorheological indicators remains unknown. This study aims to investigate the effects of postprandial lipemia on hemorheological properties and oxidative stress. Eight healthy young male participants completed two experimental trials. On day 1, the participants were randomly assigned to walk for 1 h at 50% VO2max (EE trial) or rest (CON trial). On day 2, participants rested and consumed a high-fat meal in the morning. Results: The postprandial area under the curve (AUC) of plasma TG concentration was significantly lower in EE compared to CON (EE: 9.2 ± 1.9; CON: 10.9 ± 1.7 mmol/L·h−1; p = 0.013; Cohen’s d = 0.036). No significant difference was observed in hemorheological properties and MDA (p > 0.05). Endurance exercise effectively decreased postprandial TG concentration but did not influence the postprandial hemorheological properties and oxidative stress indicators. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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15 pages, 1401 KiB  
Article
Influence of 24 h Simulated Altitude on Red Blood Cell Deformability and Hematological Parameters in Patients with Fontan Circulation
by Julian Alexander Härtel, Nicole Müller, Johannes Breuer, Jens Jordan, Jens Tank, Janina Bros, Benedikt Seeger, Emily Zollmann, Wilhelm Bloch and Marijke Grau
Metabolites 2022, 12(11), 1025; https://doi.org/10.3390/metabo12111025 - 26 Oct 2022
Cited by 3 | Viewed by 1293
Abstract
Patients with Fontan circulation are particularly dependent on low pulmonary vascular resistance because their lungs are passively perfused. Hypoxia drives pulmonary vasoconstriction; thus, red blood cell (RBC) deformability and stability of hematological parameters might be of particular importance, because alterations during hypoxia might [...] Read more.
Patients with Fontan circulation are particularly dependent on low pulmonary vascular resistance because their lungs are passively perfused. Hypoxia drives pulmonary vasoconstriction; thus, red blood cell (RBC) deformability and stability of hematological parameters might be of particular importance, because alterations during hypoxia might further influence circulation. This study aimed to measure respective parameters in patients with Fontan circulation exposed to normobaric hypoxia. A total of 18 patients with Fontan circulation (16 to 38 years) were exposed to normobaric hypoxia (15.2% ambient oxygen). Blood samples were taken in normoxia, after 24 h in hypoxia, and 60 min after return to normoxia. Blood count, RBC age distribution, EPO, RBC deformability, marker of RBC nitric oxide, oxidative state, and RBC ATP were measured. Hypoxia increased oxidative stress in RBC, but without affecting RBC deformability. RBC age distribution remained unaffected, although EPO concentrations increased, followed by a rise in reticulocyte count at an already high hematocrit. NO metabolism was not affected by hypoxia. Modest normobaric hypoxia for 24 h did not impair RBC deformability in patients with Fontan circulation; however, the oxidative system seemed to be stressed. Given the high baseline Hct in these patients, hypoxia-induced erythropoiesis could adversely affect rheology with more prolonged hypoxia exposure. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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12 pages, 1499 KiB  
Article
The Effects of Rapamycin on the Intestinal Graft in a Rat Model of Cold Ischemia Perfusion and Preservation
by Ibitamuno Caleb, Benedek Kasza, Luca Erlitz, Dávid Semjén, Péter Hardi, Lilla Makszin, Szilárd Rendeki, Ildikó Takács, Tibor Nagy and Gábor Jancsó
Metabolites 2022, 12(9), 794; https://doi.org/10.3390/metabo12090794 - 25 Aug 2022
Cited by 1 | Viewed by 1569
Abstract
Attenuating the rheological and structural consequences of intestinal ischemia-reperfusion-injury (IRI) is important in transplant proceedings. Preconditioning is an often-proposed remedy. This technique uses physical or pharmacological methods to manipulate key ischemia pathways, such as oxidation, inflammation, and autophagy, prior to ischemia. This study [...] Read more.
Attenuating the rheological and structural consequences of intestinal ischemia-reperfusion-injury (IRI) is important in transplant proceedings. Preconditioning is an often-proposed remedy. This technique uses physical or pharmacological methods to manipulate key ischemia pathways, such as oxidation, inflammation, and autophagy, prior to ischemia. This study determined the time-dependent effects of Rapamycin preconditioning on small-bowel grafts undergoing cold ischemia perfusion and preservation. Our main parameters were mucosa and cell injury and autophagy. A total of 30 male Wistar rats were divided into 5 groups: sham, preservation-control, and 3 treated groups (Rapamycin administered either 0, 30, or 60 min prior to perfusion). After perfusion, the intestines were placed in chilled IGL-1 solution for 12 h. Thereafter, they were reperfused. Histology and bioanalysis (LDH and lactate) were used to ascertain intestinal injury while immunohistochemistry was used for measuring changes in autophagy markers (Beclin-1, LC3B, and p62 proteins). The results show no significant difference amongst the groups after vascular perfusion. However, intestinal injury findings and autophagy changes demonstrate that administering Rapamycin 30 min or 60 min prior was protective against adverse cold ischemia and reperfusion of the intestinal graft. These findings show that Rapamycin is protective against cold ischemia of the small intestine, especially when administered 30 min before the onset. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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13 pages, 1210 KiB  
Article
Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats
by Barbara Barath, Adam Varga, Adam Attila Matrai, Krisztina Deak-Pocsai, Norbert Nemeth and Adam Deak
Metabolites 2022, 12(7), 602; https://doi.org/10.3390/metabo12070602 - 28 Jun 2022
Cited by 1 | Viewed by 1483
Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological and [...] Read more.
Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological and micro-rheological study on experimentally induced PCOS in rats.Wistar rats were divided into control (n = 9) and PCOS groups (n = 9), in which animals received single-dose estradiol valerate. Measurements were carried out before treatment and monthly for four months. Bodyweight, blood glucose concentration, hematological parameters, red blood cell (RBC) deformability, and aggregation were measured. A histological examination of the ovary was performed at the end of the experiment. The blood glucose level and the bodyweight were significantly elevated vs. base in the PCOS group. A significant decrease was seen in RBC count, hemoglobin, and hematocrit. The maximal elongation index showed a significant increase. PCOS also resulted in a significant increase in RBC aggregation index parameters. The histological and hormone examinations confirmed developed PCOS. The administration of estradiol valerate caused significant changes during the examined period in hematological and hemorheological parameters. Our results draw attention to the possible usefulness of micro-rheological investigations in further studies on PCOS. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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Review

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12 pages, 756 KiB  
Review
Hemorheological and Microcirculatory Relations of Acute Pancreatitis
by Robert Kotan, Katalin Peto, Adam Deak, Zsolt Szentkereszty and Norbert Nemeth
Metabolites 2023, 13(1), 4; https://doi.org/10.3390/metabo13010004 - 20 Dec 2022
Cited by 3 | Viewed by 1714
Abstract
Acute pancreatitis still means a serious challenge in clinical practice. Its pathomechanism is complex and has yet to be fully elucidated. Rheological properties of blood play an important role in tissue perfusion and show non-specific changes in acute pancreatitis. An increase in blood [...] Read more.
Acute pancreatitis still means a serious challenge in clinical practice. Its pathomechanism is complex and has yet to be fully elucidated. Rheological properties of blood play an important role in tissue perfusion and show non-specific changes in acute pancreatitis. An increase in blood and plasma viscosity, impairment of red blood cell deformability, and enhanced red blood cell aggregation caused by metabolic, inflammatory, free radical-related changes and mechanical stress contribute to the deterioration of the blood flow in the large vessels and also in the microcirculation. Revealing the significance of these changes in acute pancreatitis may better explain the pathogenesis and optimize the therapy. In this review, we give an overview of the role of impaired microcirculation by changes in hemorheological properties in acute pancreatitis. Full article
(This article belongs to the Special Issue Hemorheology and Metabolism Volume II)
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