Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 1904

Special Issue Editors


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Guest Editor
Department of Health Science´s, School of Applied Sciences – UNICAMP, Limeira, São Pauli, Brazil
Interests: molecular biology of exercise; cell metabolism; nutrition and metabolism

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Guest Editor
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Interests: molecular biology of exercise; cell metabolism; nutrition and Metabolism

Special Issue Information

Dear Colleagues,

Obesity and its associated co-morbidities are severe public health problems worldwide. An alternative to reduce the impacts of obesity and metabolic disorders resulting from excess body adiposity is to impose time-restricted feeding (TRF), an eating strategy in which access to food is limited to a variable time (commonly between eight and ten hours), leading to an extended period of fasting (i.e., >  6 h per 24 h). In the literature, preclinical studies have shown that TRF prevented the adverse effects of metabolic diseases induced by a high-fat diet, regardless of caloric intake and food composition, even in rodents with desynchrony of the circadian cycle. This scenario has aroused great scientific interest in better understanding the effects of TRF alone or combined with other pharmacological or non-pharmacological actions. Considering these notes and the promising impact of TRF, additional studies may complement and fill specific gaps in this area of knowledge. In addition, future studies should consider other assays, such as those relevant to aging, rheumatic and respiratory diseases, cancer, etc. No less important, special attention must be paid to study designs that can inform the development of future clinical trials. The analyses of differences between the sexes and repeated studies in female rodents are fundamental and should be included. This Special Issue is devoted to "Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases". The topics covered include (not exclusively) studies on the physiologic, metabolic, and molecular mechanisms in animals and humans submitted to TRF alone or combined with other therapeutic strategies.

Dr. José Rodrigo Pauli
Dr. Adelino Sanchez Ramos Da Silva
Guest Editors

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Keywords

  • time-restricted feeding
  • metabolic diseases
  • molecular adaptations
  • cell metabolism
  • hormones

Published Papers (1 paper)

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Research

18 pages, 316 KiB  
Article
Association of Christian Orthodox Fasting with Sociodemographic, Anthropometric and Lifestyle Factors and Serum Biochemical Indices: A Cross-Sectional Study on Patients with Metabolic Diseases
by Nikolaos E. Rodopaios, Efthymios Poulios, Sousana K. Papadopoulou, Olga Alexatou, Alexandra-Aikaterini Koulouri, Anthony G. Kafatos, Vasileios Papaliagkas, Evmorfia Psara, Anastasia Giannakoula, Gerasimos Tsourouflis, Georgios Antasouras and Constantinos Giaginis
Metabolites 2024, 14(1), 67; https://doi.org/10.3390/metabo14010067 - 19 Jan 2024
Viewed by 1588
Abstract
Christian Orthodox fasting, a type of time-restricted diet, which presents some similarities to the Mediterranean Diet, also including certain similarities with periodic vegetarianism or other time-restricted diets (e.g., intermittent diet and Ramadan fasting), may cumulatively be related to the same or even better [...] Read more.
Christian Orthodox fasting, a type of time-restricted diet, which presents some similarities to the Mediterranean Diet, also including certain similarities with periodic vegetarianism or other time-restricted diets (e.g., intermittent diet and Ramadan fasting), may cumulatively be related to the same or even better beneficial healthy effects as these well-recognized dietary patterns. The present study aimed to explore the potential beneficial impact of Christian Orthodox fasting in patients with metabolic disorders, such as diabetes mellitus type 2, excessive obesity, hypothyroidism and osteoporosis. This was a cross-sectional study, including 135 patients with metabolic disorders (67 fasters and 68 non-fasters). The enrolled fasters had adapted Christian Orthodox fasting recommendations for at least twelve consecutive years or even from childhood. Relevant questionnaires were used to record sociodemographic, anthropometric and lifestyle data of the study population through face-to-face interviews between the enrolled individuals and qualified personnel during a non-fasting period. Christian Orthodox fasting patients showed a significantly and independently lower prevalence of overweight/obesity and abdominal obesity, which is highly associated with cardiometabolic disease risks, as well as a significantly and independently lower incidence of hypertension, including separately lower systolic and diastolic pressure, than non-fasting patients. Fasters also had a significantly and independently increased prevalence of an advanced educational level and no smoking history, as well as a lower incidence of sedentary behavior, and a trend of a correlation with reduced c-reactive protein (CRP), an indicator of inflammation, compared to non-fasters. Fasters also exhibited higher serum albumin and high-density lipoprotein (HDL) levels, as well as lower glucose levels, than non-fasters. This is one of the few cross-sectional studies demonstrating that Christian Orthodox fasting may promote metabolic health by improving several aspects of metabolic disorders, being associated with specific sociodemographic, anthropometric and lifestyle factors. Further studies conducted on larger sample sizes from different countries and different ethnicities that include Christian Orthodox fasters are recommended to evaluate the impact of long-term religious fasting effects on human health, either as a preventative factor reducing the risk of chronic diseases and especially cardiometabolic disorders or as a nutritional intervention to ameliorate symptom severity. Full article
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