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Metabolites
Special Issues
Newborn Metabolomic Profile
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Newborn Metabolomic Profile

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1488

Special Issue Editors

Dr. Giuseppe De Bernardo

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Guest Editor
Department of Woman and Child, Ospedale Buon Consiglio Fatebenefratelli, 80123 Naples, Italy
Interests: neonatal intensive care; mechanical ventilation; neonatal Resuscitation
Dr. Maurizio Giordano

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Guest Editor
Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy
Interests: newborn metabolomic
Prof. Dr. Giuseppe Buonocore

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Guest Editor
Department of Molecular and Developmental Medicine, General Hospital "Santa Maria alle Scotte", University of Siena, Siena, Italy
Interests: evaluation of new antioxidant drugs; role of oxidative stress in perinatal diseases; free radicals, proteomics and metabolomics; ethics and research in neonatology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Serafina Perrone

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Guest Editor
Neonatology Unit, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
Interests: pediatrics; intensive care; oxidative stress; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolomics is considered today the key for personalized medicine, as it is able to correlate biochemical changes with a determined phenotype and obtain real information about the state of health of a subject at that precise moment. The results of the metabolomics study on newborns can allow an early recognition of potentially pathological changes. It is important to classify and be able to recognize early all risk factors that can alter the metabolism of newborns. The early recognition of risk factors can allow for the development of new methods of diagnosis, follow-up, and treatments. Maternal nutrition, the mother's health, the course of pregnancy, breastfeeding, birth assistance, or genetic, metabolic, or acquired disorders can alter the metabolism of the newborn. The metabolomics study can allow for the identification of newborn pathologies and the personalization of newborn care. We want to explore every possible application that the study of metabolomics can have on the health of the newborn.

Dr. Giuseppe De Bernardo
Dr. Maurizio Giordano
Prof. Dr. Giuseppe Buonocore
Prof. Dr. Serafina Perrone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • newborn metabolomic
  • inborn errors of metabolism
  • personalized medicine
  • pathophysiology mechanism
  • maternal nutrition
  • breastfeeding
  • pregnancy
  • assisted fertilization
  • diagnostic markers
  • therapeutic strategies

Published Papers (1 paper)

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Research

12 pages, 3149 KiB  
Article
Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns
by Yuhan Xie, Gang Peng, Hongyu Zhao and Curt Scharfe
Metabolites 2024, 14(1), 5; https://doi.org/10.3390/metabo14010005 - 20 Dec 2023
Viewed by 1162
Abstract
Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on [...] Read more.
Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as age at blood collection, birth weight, gestational age, infant sex, parent-reported ethnicity, and maternal age at delivery. Marker levels were compared between maternal age groups (age range: 1544 years) using effect size analyses, which controlled for differences in group sizes and potential confounding from other covariates. We found that 13% of the markers had maternal age-related differences, including newborn metabolites with either increased (Tetradecanoylcarnitine [C14], Palmitoylcarnitine [C16], Stearoylcarnitine [C18], Oleoylcarnitine [C18:1], Malonylcarnitine [C3DC]) or decreased (3-Hydroxyisovalerylcarnitine [C5OH]) levels at an advanced maternal age (≥35 years, absolute Cohen’s d > 0.2). The increased C3DC levels in this group correlated with a higher false-positive rate in newborn screening for malonic acidemia (p-value < 0.001), while no significant difference in screening performance was seen for the other markers. Maternal age is associated with inborn metabolic differences and should be considered together with other clinical variables in genetic disease screening. Full article
(This article belongs to the Special Issue Newborn Metabolomic Profile)
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