Oxidative Stress and Lung Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 5135
Special Issue Editors
Interests: oxidative stress; newborn; ventilation; melatonin
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress; newborn; antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The number of diseases in which detrimental oxidative stress has been proposed to play a causative or exacerbating role has grown steadily over the past two decades. Among them, the most prevalent one is oxidant-mediated lung disease.
Neonates experience an abrupt surge in oxygen (O2) tension immediately after birth when their antioxidant defense system is not fully developed. The more than fivefold increase in O2 tension causes oxidative stress, which can worsen when neonates present respiratory distress that requires supplemental O2 to maintain tissue metabolism. There is evidence that the oxidative stress involved in the physiopathology of lung disease is particularly related to oxygen supplementation, mechanical ventilation, inflammation/infection, and diabetes.
The oxidant burden in the lung is enhanced during infection by the release of reactive oxygen species from macrophages and neutrophils. Moreover, oxidative stress can itself elicit the inflammatory process, inhibit cell growth, and impair angiogenesis, thus preventing the lung from adequate growth. Unfortunately, antioxidant treatment has not shown clinical efficacy so far. Understanding how the downstream effects of oxidative stress lead to lung injury is important to allow normal lung growth in neonates.
We invite you to submit your latest research results or a review article to this Special Issue, which will bring together current research findings related to lung injury due to oxidative stress in newborns and children and the therapeutic action of antioxidant treatments.
We look forward to your contribution.
Prof. Dr. Eloisa Gitto
Prof. Dr. Serafina Perrone
Guest Editors
Manuscript Submission Information
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Keywords
- oxidative stress
- lung
- newborn
- critically children
- ventilation
- respiratory distress syndrome
