Gallbladder, Bile Duct and Pancreas Disorders: Current Challenges, New Perspectives and Innovative Techniques

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1833

Special Issue Editors


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Surgical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: laparoscopic surgery; hernia; gastrectomy
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2nd Surgical Department, Aristotle University of Thessaloniki, “G. Gennimatas” Hospital, Thessaloniki, Greece
Interests: gastroenterology
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Emergency Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece
Interests: emergency medicine; internal medicine; diabetes; hypertension
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Special Issue Information

Dear Colleagues,

Gallbladder, bile duct and pancreas disorders are highly frequent and characterized by heterogeneity. Innovate technologies are used for the diagnosis and management of these disorders, allowing for the medical community to identify, locate and treat them. Entering this field, artificial intelligence is offering solutions to difficult cases of clinical practice. Additionally, minimally invasive surgical and endoscopic procedures, as well as robotic surgery, render higher chances for the successful management of the patients of these disorders. Moreover, oncology treatments are evolving, employing a wide range of biological medicines and opening a new era in therapy for gallbladder, bile duct and pancreas disorders.

The aim of this Special Issue is to evaluate and discuss current challenges, new perspectives and innovative techniques for gallbladder, bile duct and pancreas disorders, including differential diagnosis, pharmacotherapy, treatment, final outcome and prognosis.

We invite colleagues around the world to report their experience and knowledge with original studies, reviews, case reports or communications in current challenges, new perspectives and innovative techniques relating disorders of the gallbladder, bile ducts and pancreas for this Special Issue of our journal, in order to support this dominant research area.

You may choose our Joint Special Issue in JCM.

Prof. Dr. Daniel Paramythiotis
Prof. Dr. Robert Grützmann
Prof. Dr. Vasileios Papaziogas
Dr. Dimitrios Raptis
Dr. Eleni Karlafti
Guest Editors

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Keywords

  • pancreas
  • biliary tract
  • pancreatobiliary diseases
  • pancreas neoplasm
  • tumor
  • ERCP
  • EUS
  • management
  • therapy
  • technique
  • surgery

Published Papers (3 papers)

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8 pages, 503 KiB  
Case Report
Biliary Ascariasis in a Pediatric Patient in Lithuania: Case Report and Literature Review
by Rūta Rokaitė, Mindaugas Dženkaitis, Melita Nedzinskaitė and Rūta Kučinskienė
Medicina 2024, 60(6), 916; https://doi.org/10.3390/medicina60060916 - 30 May 2024
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Abstract
Abstract: Hepatobiliary ascariasis is caused by the entry of the nematode A. lumbricoides from the duodenum into the biliary duct. We report a case of an Ascaris-induced extrahepatic biliary tract obstruction in a pediatric patient admitted to the hospital due to [...] Read more.
Abstract: Hepatobiliary ascariasis is caused by the entry of the nematode A. lumbricoides from the duodenum into the biliary duct. We report a case of an Ascaris-induced extrahepatic biliary tract obstruction in a pediatric patient admitted to the hospital due to a wide spectrum of symptoms of biliary disease, which included abdominal pain in the upper abdominal quadrants, vomiting, and jaundice. Imaging tests—including ultrasound, magnetic resonance cholangiopancreatography (MRCP), and endoscopic retrograde cholangiopancreatography (ERCP)—were performed to confirm the diagnosis of biliary ascariasis. The tests did, in fact, demonstrate signs of this disease. Nevertheless, during the ERCP, only the remains of Ascaris parasites in the form of tissue fragments were extracted. We also aim to discuss the prevalence of ascariasis in children, the causes of migration of Ascaris parasites into the bile ducts, together with its clinical manifestations, as well as the diagnostic and treatment methods of this disease. Full article
7 pages, 2212 KiB  
Case Report
Penoscrotal Edema as a Rare Complication of Acute Pancreatitis: A Case Report
by Ivana Jukic, Visnja Kokic Males, Antonija Zanic and Ivan Zaja
Medicina 2024, 60(5), 820; https://doi.org/10.3390/medicina60050820 - 16 May 2024
Viewed by 477
Abstract
Background and Objectives: Scrotal swelling or hydrocele is a rare complication of acute pancreatitis described in the literature. We present a case of penoscrotal swelling caused by the first attack of acute interstitial edematous alcohol-induced pancreatitis in a young male patient. Case [...] Read more.
Background and Objectives: Scrotal swelling or hydrocele is a rare complication of acute pancreatitis described in the literature. We present a case of penoscrotal swelling caused by the first attack of acute interstitial edematous alcohol-induced pancreatitis in a young male patient. Case report: A 22-year-old man was admitted to the emergency unit due to diarrhea and vomiting since morning which was followed by severe abdominal pain. Urgent abdominal multislice CT scan showed steatosis, pancreatic swelling and acute peripancreatic fluid collection (interstitial edematous pancreatitis). Also, scan showed fluid between small bowel loops and along the anterior renal fascia, while there was minimal amount of fluid in the Douglas space. There was no sign of penoscrotal swelling. On the second day of admission, the patient developed left scrotal swelling and mild pain without erythema. On the fourth day, a control CT scan showed progression to moderately severe pancreatitis (CT severity index 4). Dilated scrotal veins of the pampiniform venous plexus with an increased caliber of the testicular veins were present on both sides, from the scrotum to the level of the inguinal canal. Penoscrotal swelling was significantly reduced on discharge. Conclusions: Penoscrotal swelling is a rare complication or manifestation of acute inflammation of the pancreas. It is important to identify scrotal swelling caused by pancreatitis because in severe cases it can be related to possible infertility in the future. Full article
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22 pages, 1200 KiB  
Systematic Review
Revolutionizing the Pancreatic Tumor Diagnosis: Emerging Trends in Imaging Technologies: A Systematic Review
by Sabina Florina Șolea, Mihaela Cristina Brisc, Alexandra Orășeanu, Florian Ciprian Venter, Ciprian Mihai Brisc, Răzvan Mihai Șolea, Lavinia Davidescu, Amina Venter and Ciprian Brisc
Medicina 2024, 60(5), 695; https://doi.org/10.3390/medicina60050695 - 24 Apr 2024
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Abstract
Background and Objectives: The pancreas, ensconced within the abdominal cavity, requires a plethora of sophisticated imaging modalities for its comprehensive evaluation, with ultrasonography serving as a primary investigative technique. A myriad of pancreatic pathologies, encompassing pancreatic neoplasia and a spectrum of inflammatory [...] Read more.
Background and Objectives: The pancreas, ensconced within the abdominal cavity, requires a plethora of sophisticated imaging modalities for its comprehensive evaluation, with ultrasonography serving as a primary investigative technique. A myriad of pancreatic pathologies, encompassing pancreatic neoplasia and a spectrum of inflammatory diseases, are detectable through these imaging strategies. Nevertheless, the intricate anatomical confluence and the pancreas’s deep-seated topography render the visualization and accurate diagnosis of its pathologies a formidable endeavor. The objective of our paper is to review the best diagnostic imagistic tools for the pancreas. Materials and Methods: we have gathered several articles using Prisma guidelines to determine the best imagistic methods. The imperative of pancreatic scanning transcends its diagnostic utility, proving to be a pivotal element in a multitude of clinical specialties, notably surgical oncology. Within this domain, multidetector computed tomography (MDCT) of the pancreas holds the distinction of being the paramount imaging modality, endorsed for its unrivaled capacity to delineate the staging and progression of pancreatic carcinoma. In synergy with MDCT, there has been a notable advent of avant-garde imaging techniques in recent years. These advanced methodologies, including ultrasonography, endoscopic ultrasonography, contrast-enhanced ultrasonography, and magnetic resonance imaging (MRI) conjoined with magnetic resonance cholangiopancreatography (MRCP), have broadened the horizon of tumor characterization, offering unparalleled depth and precision in oncological assessment. Other emerging diagnostic techniques, such as elastography, also hold a lot of potential and promise for the future of pancreatic imaging. Fine needle aspiration (FNA) is a quick, minimally invasive procedure to evaluate lumps using a thin needle to extract tissue for analysis. It is less invasive than surgical biopsies and usually performed as an outpatient with quick recovery. Its accuracy depends on sample quality, and the risks include minimal bleeding or discomfort. Results, guiding further treatment, are typically available within a week. Elastography is a non-invasive medical imaging technique that maps the elastic properties and stiffness of soft tissue. This method, often used in conjunction with ultrasound or MRI, helps differentiate between hard and soft areas in tissue, providing valuable diagnostic information. It is particularly useful for assessing liver fibrosis, thyroid nodules, breast lumps, and musculoskeletal conditions. The technique is painless and involves applying gentle pressure to the area being examined. The resulting images show tissue stiffness, indicating potential abnormalities. Elastography is advantageous for its ability to detect diseases in early stages and monitor treatment effectiveness. The procedure is quick, safe, and requires no special preparation, with results typically available immediately. Results: The assembled and gathered data shows the efficacy of various techniques in discerning the nature and extent of neoplastic lesions within the pancreas. Conclusions: The most common imaging modalities currently used in diagnosing pancreatic neoplasms are multidetector computed tomography (MDCT), endoscopic ultrasound (EUS), and magnetic resonance imaging (MRI), alongside new technologies, such as elastography. Full article
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