Non-motor Disorders in Parkinson’s Disease and Other Parkinsonian Syndromes, 2nd Edition

Dear Colleagues,

Parkinson’s disease (PD) is the second most common multi-systemic neurodegenerative disorder that is characterized by a broad spectrum of motor and non-motor symptoms (NMS). Atypical Parkinsonism is a less common group of sporadic, neurodegenerative diseases of the central nervous system but more severe than PD. The most common forms are multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). Neuroanatomically, NMS may be subdivided into cortical manifestations (psychosis and cognitive impairment), basal ganglia symptoms (impulse control disorders, apathy, and restlessness or akathisia), brainstem symptoms (depression, anxiety, and sleep disorders), and peripheral nervous system disturbances (orthostatic hypotension (OH), constipation, pain), and sensory disturbances. NMS is often overlooked by physicians and dismissed by patients, making its management difficult and a major burden for patients and caregivers. Unfortunately, there is very little existing data about NMS, their neurobiology, their potential biomarkers, their monitoring, and their treatment. Moreover, there is growing evidence of accurate monitoring of NMS by wearable sensors for PD. It is, therefore, essential that researchers and practitioners comprehensively address the factors related to NMS in order to improve the quality of life for PD patients.

The aim of the 2nd edition of this Special Issue is to welcome back research articles, opinion/perspective articles, and review articles (narrative reviews, systematic reviews, and meta-analyses), as well as preclinical studies with animal models.

Dr. Anastasia Bougea
Guest Editor

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• Parkinson’s disease (PD)
• non-motor symptoms
• atypical Parkinsonism
• genetics
• biomarkers
• wearable sensors