Traditional Medicine for the Treatment of Pulmonary Hypertension (PH): Is the Answer in the Nature?

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (1 August 2020) | Viewed by 5609

Special Issue Editors


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Guest Editor
Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
Interests: pulmonary hypertension; high-altitude medicine; lung fibrosis

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Co-Guest Editor
Pulmonology Department, Sechenov First Moscow State Medical University, 119992 Moscow, Russia
Interests: pulmonary hypertension; idiopathic pulmonary fibrosis; COPD; chronic lung diseases; therapy
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Co-Guest Editor
University of Kent, Canterbury, UK
Interests: pulmonary hypertension; pulmonary vascular diseases; schistosomiasis; infections; inflammation

Special Issue Information

Dear Colleagues,

In the last two decades, a tremendous amount of scientific work has been done with a focus on the pathology/pathophysiology, underlying molecular mechanisms, and signalling pathways, in the field of pulmonary hypertension. Similarly, valuable clinical efforts were achieved, resulting in the discovery of several therapeutic options and strategies for the treatment of this disease. However, despite all the above-mentioned scientific and clinical efforts in the past, this severe and progressive pulmonary vascular disease is still enigmatic and incurable.

Accordingly, we have recently summarized the knowledge provided from outside of Western civilization and identified a plethora of different and potentially effective therapeutic options derived from natural plant products, including alkaloids, flavonoids, glycosides, diterpenoids, pyranocoumarins, and stilbenes (Kosanovic et al, Pulm Circ 2013; Xiang et al, Pulm Circ 2018). In particular, the “Materia Medica” of Ancient China could be a very useful and interesting starting point.

Therefore, the general topic of this Special Issue of the Medicina is about the potential future application of traditional medicine for the treatment of pulmonary hypertension. Both original studies and review papers are welcome. With regard to the original articles, the studies covering the systematic in vivo research using relevant animal models of pulmonary hypertension or profound in vitro work related to underlying molecular mechanisms and signalling pathways are both welcome. Finally, studies dealing with the investigation of the therapeutic potency of traditional medicine and natural products in humans are strongly desirable.

Dr. Djuro Kosanovic
Prof. Dr. Sergey Avdeev
Prof. Dr. Ghazwan Butrous
Guest Editors

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Keywords

  • Pulmonary hypertension: pathology
  • Pulmonary hypertension: therapy
  • Traditional medicine
  • Traditional Chinese medicine
  • Natural (plant) products
  • Animal models and in vivo research
  • Signalling pathways and molecular mechanisms.

Published Papers (1 paper)

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Research

9 pages, 7466 KiB  
Article
Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
by Himal Luitel, Tatyana Novoyatleva, Akylbek Sydykov, Aleksandar Petrovic, Argen Mamazhakypov, Bhuminand Devkota, Malgorzata Wygrecka, Hossein Ardeschir Ghofrani, Sergey Avdeev, Ralph Theo Schermuly and Djuro Kosanovic
Medicina 2020, 56(3), 131; https://doi.org/10.3390/medicina56030131 - 16 Mar 2020
Cited by 3 | Viewed by 5025
Abstract
Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of the general [...] Read more.
Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of the general public and scientific communities. The entomogenous fungus Yarsagumba (Cordyceps sinensis) and its biologically active ingredient cordycepin may represent the therapeutic option for this incurable disease, owing to their anti-inflammatory, vasodilatory and anti-oxidative effects. Methods: In this study, we investigated whether Yarsagumba extract and cordycepin possess anti-proliferative and vasorelaxant properties in the context of PH, using 5-bromo-2’-deoxyuridine assay and isolated mice lungs, respectively. Results: Our results revealed that Yarsagumba extract and its bioactive compound cordycepin significantly attenuated the proliferation of human pulmonary artery smooth muscle cells derived from donor and PH subjects. In isolated murine lungs, only Yarsagumba extract, but not cordycepin, resulted in vasodilatation, indicating the probable existence of other bioactive metabolites present in Yarsagumba that may be responsible for this outcome. Conclusion: Future comprehensive in vivo and in vitro research is crucially needed to discover the profound mechanistic insights with regard to this promising therapeutic potency of Yarsagumba extract and to provide further evidence as to whether it can be used as a strategy for the treatment of PH. Full article
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