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Medicina
Special Issues
Medical Imaging in Hepatology
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Medical Imaging in Hepatology

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1372

Special Issue Editors

Dr. Felix Bende

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Guest Editor
1. Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
2. Advanced Regional Research Center in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
Interests: hepatology; liver cirrhosis; elastography; liver biopsy; ultrasound; CEUS; interventional ultrasonography; portal hypertension; liver diseases; NASH; ultrasound imaging; non-invasive diagnosis
Prof. Dr. Alina Popescu

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Guest Editor
1. Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, Piața Eftimie Murgu 2, 300041 Timișoara, Romania
2. Center of Advanced Research in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: liver cirrhosis; hepatitis; liver; medicine; hepatocellular carcinoma; elastography; gastroenterology; liver diseases; viral hepatitis; ultrasound; hepatology; liver biopsy; chronic hepatitis c; ultrasonography; cirrhosis; acoustics; microbubbles; fatty liver; liver failure; hepatitis c
Special Issues, Collections and Topics in MDPI journals
Dr. Matteo Rosselli

E-Mail Website
Guest Editor
1. Department of Internal Medicine, San Giuseppe General Hospital, 50053 Empoli, Italy
2. Division of Medicine, UCL Institute for Liver and Digestive Health, Royal Free Hospital, London NW3 2PF, UK
Interests: liver diseases; cirrhosis; non-invasive diagnosis; advanced ultrasound; portal hypertension; elastography

Special Issue Information

Dear Colleagues,

Chronic liver diseases represent a major global public health problem, especially when they reach the stage of cirrhosis and portal hypertension, with an estimated 2 million deaths each year. The diagnostic panel in hepatology has significantly evolved from traditional invasive methods, such as liver biopsy and hepatic venous pressure gradient measurements, to sophisticated non-invasive tools, including biochemistry and a multitude of ultrasound and magnetic resonance-based methods that are likely to be enhanced by artificial intelligence. Imaging plays a crucial role in the management of liver diseases, as it allows for early detection, accurate diagnosis, and monitoring of disease progression. It also helps in guiding interventional procedures and assessing treatment effectiveness. Ultrasonography and ultrasound-based methods are in continuous development, with a particular impact in recent years on the evaluation and management of chronic liver diseases, allowing the non-invasive evaluation of liver fibrosis, liver steatosis and, more recently, hepatic inflammation, with an important role in fibrogenesis.

In this Special Issue of Medicina, we aim to collate the current knowledge and apply it to emerging research in the field of imaging techniques in liver diseases, focusing on ultrasound and ultrasound-based methods.

We look forward to receiving your contributions. 

Dr. Felix Bende
Dr. Alina Popescu
Dr. Matteo Rosselli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver imaging
  • liver cirrhosis
  • liver fibrosis
  • non-invasive assessment
  • ultrasound imaging

Published Papers (1 paper)

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9 pages, 769 KiB  
Case Report
A Lithuanian Case of Tyrosinemia Type 1 with a Literature Review: A Rare Cause of Acute Liver Failure in Childhood
by Rūta Rokaitė, Agnė Čibirkaitė, Vykinta Zeleckytė, Gabija Lazdinytė and Mindaugas Dženkaitis
Medicina 2024, 60(1), 135; https://doi.org/10.3390/medicina60010135 - 11 Jan 2024
Viewed by 1007
Abstract
Hereditary type 1 tyrosinemia (HT1) is a rare inherited autosomal recessive disorder of tyrosine metabolism, characterized by progressive liver damage, dysfunction of kidney tubules, and neurological crises. In the course of this disease, due to the deficiency of the enzyme fumarylacetoacetate hydrolase (FAH), [...] Read more.
Hereditary type 1 tyrosinemia (HT1) is a rare inherited autosomal recessive disorder of tyrosine metabolism, characterized by progressive liver damage, dysfunction of kidney tubules, and neurological crises. In the course of this disease, due to the deficiency of the enzyme fumarylacetoacetate hydrolase (FAH), toxic intermediate metabolites of tyrosine breakdown, such as fumarylacetoacetate (FAA), succinylacetoacetate (SAA), and succinylacetone (SA), accumulate in liver and kidney cells, causing cellular damage. Because of this, an increased SA concentration in the blood or urine is pathognomonic of HT1. In the year 2000, HT1 was diagnosed in Lithuania for the first time, and this was the first time when a specific treatment for HT1 was administered in the country. Over two decades, four cases of this disease have been diagnosed in Lithuania. In the first of these patients, the disease was diagnosed in infancy, manifesting as liver damage with liver failure. Treatment with nitisinone was initiated, which continues to be administered, maintaining normal liver function. Liver transplantation was performed on two subsequent patients due to complications of HT1. It is crucial to diagnose HT1 as early as possible in order to reduce or completely eliminate complications related to the disease, including progressive liver failure and kidney dysfunction, among others. This can only be achieved by conducting a universal newborn screening for tyrosinemia and by starting treatment with nitisinone (NTBC) before the age of 1 month in all cases of HT1. However, in those countries where this screening is not being carried out, physicians must be aware of and consider this highly rare disorder. They should be vigilant, paying attention to even minimal changes in a few specific laboratory test results—such as unexplained anemia alongside neutropenia and thrombocytopenia—and should conduct more detailed examinations to determine the causes of these changes. In this article, we present the latest clinical case of HT1 in Lithuania, diagnosed at the Children’s Diseases’ Clinic of the Lithuanian University of Health Sciences (LUHS) Hospital Kaunas Clinics. The case manifested as life-threatening acute liver failure in early childhood. This article explores and discusses the peculiarities of diagnosing this condition in the absence of universal newborn screening for tyrosinemia in the country, as well as the course, treatment, and ongoing monitoring of patients with this disorder. Full article
(This article belongs to the Special Issue Medical Imaging in Hepatology)
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