Urinary Tract Infections: Pathophysiology, Epidemiology and Management

Dear Colleagues,

Urinary tract infections (UTIs) represent a major public health problem as one of the most common infectious diseases, second to upper respiratory tract infections. More than 50% of all women and at least 12% of men experience a UTI in their lifetime.

Data on UTI prevalence in the general population are scanty in some areas, indicating the need to regularly monitor the burden of UTIs to inform policy decisions. The integrative approach to UTIs has an important role in improving patient prognosis, which implies that, in most cases, antimicrobial therapy should often be prescribed empirically. In order to implement appropriate empirical therapy, it is essential to know the main bacteria commonly involved in UTI pathology, as well as their antibiotic resistance profile. This approach reduces the incidence of antimicrobial resistance and prevents the spread of bacterial strains resistant to multiple antibiotics.

UTIs caused by multidrug-resistant Enterobacterales represent a rising concern due to the paucity of therapeutical options available, especially in countries with high resistance rates. Thus, a dynamic assessment of regional isolates’ resistance patterns and constantly updated knowledge of the microorganisms most commonly involved are crucial in choosing an appropriate empiric antibiotic therapy for UTIs.

Therefore, this Special Issue aims to create an opportunity to update information on the epidemiology and particularities of UTIs, as well as the newest insights into innovative approaches for UTI management.

This Special Issue welcomes all submissions related to the diagnosis and treatment of UTIs, including original research articles, reviews and opinion papers.

Dr. Ionela-Larisa Miftode
Prof. Dr. Mihaela Cǎtǎlina Luca
Guest Editors

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• urinary tract infections
• antibiotic resistance
• risk factors
• prevention
• Enterobacterales
• catheter-associated urinary tract infections