Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
2.6
Journals
Medicina
Special Issues
The Antimicrobial Peptides and Their Therapeutic Potential
share announcement

The Antimicrobial Peptides and Their Therapeutic Potential

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Infectious Disease".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1308

Special Issue Editor

Dr. Amit K. Tripathi

E-Mail Website
Guest Editor
Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Interests: antimicrobial peptides; cancer therapy; antimicrobial resistance; sepsis

Special Issue Information

Dear Colleagues,

The Special Issue of this journal, titled "The Antimicrobial Peptides and Their Therapeutic Potential", explores the critical role of antimicrobial peptides (AMPs) and their promising therapeutic applications. AMPs are naturally occurring molecules that play a pivotal role in the innate immune system, defending against various pathogens, including bacteria, viruses, and fungi.

This Special Issue delves into the multifaceted aspects of AMPs, encompassing their mechanisms of action, structural diversity, and their ability to combat drug-resistant microbes. Furthermore, it highlights the potential of AMPs in developing novel treatments for infectious diseases, offering a ray of hope in the battle against antibiotic resistance. Contributions in this Special Issue will discuss the latest research findings, clinical trials, and innovative strategies for harnessing AMPs' therapeutic potential. By shedding light on the remarkable properties and applications of these peptides, this collection of articles seeks to advance our understanding of AMPs and pave the way for novel antimicrobial therapies, addressing one of the most pressing challenges in modern medicine.

Dr. Amit K. Tripathi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptides
  • therapeutic potential
  • innate immune system
  • drug-resistant microbes
  • antibiotic resistance
  • mechanisms of action
  • structural diversity
  • novel treatments
  • infectious diseases
  • clinical trials

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

0 pages, 9055 KiB  
Article
Unravelling the Antimicrobial, Antibiofilm, Suppressing Fibronectin Binding Protein A (fnba) and cna Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized Solanum lycopersicum Silver Nanoparticles
by Alsayed E. Mekky, Ahmed E. M. Abdelaziz, Fady Sayed Youssef, Shymaa A. Elaskary, Aly A. Shoun, Eman A. Alwaleed, Mahmoud Ali Gaber, Abdulaziz A. Al-Askar, Alhadary M. Alsamman, Abdullah Yousef, Gehad AbdElgayed, Reda A. Suef, Mohamed A Selim, Ebrahim Saied and Mohamed Khedr
Medicina 2024, 60(3), 515; https://doi.org/10.3390/medicina60030515 - 21 Mar 2024
Viewed by 1099
Abstract
Background and Objectives: Urinary tract infections [UTIs] are considered the third most known risk of infection in human health around the world. There is increasing appreciation for the pathogenicity of Gram-positive and Gram-negative strains in UTIs, aside from fungal infection, as they [...] Read more.
Background and Objectives: Urinary tract infections [UTIs] are considered the third most known risk of infection in human health around the world. There is increasing appreciation for the pathogenicity of Gram-positive and Gram-negative strains in UTIs, aside from fungal infection, as they have numerous virulence factors. Materials and Methods: In this study, fifty urine samples were collected from patients suffering from UTI. Among the isolates of UTI microbes, six isolates were described as MDR isolates after an antibiotic susceptibility test carried out using ten different antibiotics. An alternative treatment for microbial elimination involved the use of biosynthesized silver nanoparticles (AgNPs) derived from Solanum lycopersicum [S. cumin]. Results: The sizes and shapes of AgNPs were characterized through TEM imaging, which showed spherical particles in a size range of 35–80 nm, of which the average size was 53 nm. Additionally, the silver nanoparticles (AgNPs) demonstrated inhibitory activity against Staphylococcus aureus (OR648079), exhibiting a 31 mm zone of inhibition at a minimum inhibitory concentration (MIC) of 4 mg/mL and a minimum bactericidal concentration (MBC) of 8 mg/mL. This was followed by Aspergillus niger (OR648075), which showed a 30 mm inhibition zone at an MIC of 16 mg/mL and a minimum fungicidal concentration (MFC) of 32 mg/mL. Then, Enterococcus faecalis (OR648078), Klebsiella pneumoniae (OR648081), and Acinetobacter baumannii (OR648080) each displayed a 29 mm zone of inhibition at an MIC of 8 mg/mL and an MBC of 16 mg/mL. The least inhibition was observed against Candida auris (OR648076), with a 25 mm inhibition zone at an MIC of 16 mg/mL and an MFC of 32 mg/mL. Furthermore, AgNPs at different concentrations removed DPPH and H2O2 at an IC50 value of 13.54 μg/mL. Also, AgNPs at 3 mg/mL showed remarkable DNA fragmentation in all bacterial strains except Enterococcus faecalis. The phytochemical analysis showed the presence of different active organic components in the plant extract, which concluded that rutin was 88.3 mg/g, garlic acid was 70.4 mg/g, and tannic acid was 23.7 mg/g. Finally, AgNPs concentrations in the range of 3–6 mg/mL showed decreased expression of two of the fundamental genes necessary for biofilm formation within Staphylococcus aureus, fnbA (6 folds), and Cna (12.5 folds) when compared with the RecA gene, which decreased by one-fold when compared with the control sample. These two genes were submitted with NCBI accession numbers [OR682119] and [OR682118], respectively. Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs. Full article
(This article belongs to the Special Issue The Antimicrobial Peptides and Their Therapeutic Potential)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop