Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
2.6
Journals
Medicina
Special Issues
Advances in ME/CFS Research and Clinical Care: Part II
share announcement

Advances in ME/CFS Research and Clinical Care: Part II

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 25055

Special Issue Editors

Prof. Dr. Hitomi Kataoka

E-Mail Website
Guest Editor
Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama 700-8558, Japan
Interests: medical education; empathy; general medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fumio Otsuka

E-Mail Website
Guest Editor
Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Interests: adrenal diseases; endocrine disorders; laboratory medicine; long COVID; pituitary diseases; steroid hormones; thyroid diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hirohiko Kuratsune

E-Mail Website
Guest Editor
1. School of Medicine, Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Osaka, Japan
2. Graduate School of Medicine, Division of Health Sciences, Osaka University, Osaka, Japan
Interests: myalgic encephalomyelitis/chronic fatigue syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue entitled “Advances in ME/CFS Research and Clinical Care: Part II”. This is a second volume, having published eight papers in the first volume that were viewed 60,930 times. For more details, please visit https://www.mdpi.com/journal/medicina/special_issues/ME_AND_CFS.

Recently, there has been a greater focus on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, the blood and urine tests and imaging tests currently used in daily practice do not show any clear abnormal findings. In addition, the fact that the disease is named after a symptom that everyone experiences, “fatigue”, leads to underestimation and lack of understanding, as the disease is misconstrued as “laziness under the pretext of fatigue when there is no particular abnormality”. On the other hand, several patients who contracted COVID-19 have sequelae known as “long COVID”. There are many reports that suggest the similarity of ME/CFS to long COVID. However, we do not fully understand the relationship between these conditions. Thus, in this Special Issue, we hope to increase our understanding of ME/CFS and epidemiologic and clinical facts about long COVID.

We are aiming to solicit papers on the topics of epidemiologic and clinical facts about long COVID, diagnosis of ME/CFS in patients who have long COVID, and treatment and management of ME/CFS and long COVID.

Prof. Dr. Hitomi Kataoka
Prof. Dr. Fumio Otsuka
Prof. Dr. Hirohiko Kuratsune
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ME/CFS
  • long COVID
  • myalgic encephalomyelitis/chronic fatigue syndrome

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Other

13 pages, 1715 KiB  
Hypothesis
Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evolving from the Post COVID-19 Syndrome
by Klaus Josef Wirth and Matthias Löhn
Medicina 2024, 60(2), 194; https://doi.org/10.3390/medicina60020194 - 23 Jan 2024
Viewed by 1529
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients develop the full clinical picture of ME/CFS. New observations [...] Read more.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients develop the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and the expression of adhesion molecules in the capillaries. These disturbances can finally cause a low capillary flow and even capillary stasis. A low cardiac stroke volume due to hypovolemia and the inability of the capacitance vessels to adequately constrict to deliver the necessary cardiac preload generate an unfavorable low precapillary perfusion pressure. Furthermore, a predominance of vasoconstrictor over vasodilator influences exists, in which sympathetic hyperactivity and endothelial dysfunction play a strong role, causing the constriction of resistance vessels and of precapillary sphincters, which leads to a fall in capillary pressure behind the sphincters. The interaction of these two precapillary cardiovascular mechanisms causing a low capillary perfusion pressure is hemodynamically highly unfavorable in the presence of a primary capillary stasis, which is already caused by the pathological blood components and their interaction with the capillary wall, to severely impair organ perfusion. The detrimental coincidence of microcirculatory and precapillary cardiovascular disturbances may constitute the key disturbance of the Post-COVID-19 syndrome and finally lead to ME/CFS in predisposed patients because the interaction causes a particular kind of perfusion disturbance—capillary ischemia/reperfusion—which has a high potential of causing mitochondrial dysfunction by inducing sodium- and calcium-overload in skeletal muscles. The latter, in turn, worsens the vascular situation through the generation of reactive oxygen species to close a vicious cycle from which the patient can hardly escape. Full article
(This article belongs to the Special Issue Advances in ME/CFS Research and Clinical Care: Part II)
►▼ Show Figures

Figure 1

10 pages, 324 KiB  
Opinion
Why the Psychosomatic View on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Inconsistent with Current Evidence and Harmful to Patients
by Manuel Thoma, Laura Froehlich, Daniel B. R. Hattesohl, Sonja Quante, Leonard A. Jason and Carmen Scheibenbogen
Medicina 2024, 60(1), 83; https://doi.org/10.3390/medicina60010083 - 31 Dec 2023
Cited by 1 | Viewed by 23158
Abstract
Since 1969, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been classified as a neurological disease in the International Classification of Diseases by the World Health Organization. Although numerous studies over time have uncovered organic abnormalities in patients with ME/CFS, and the majority of researchers [...] Read more.
Since 1969, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been classified as a neurological disease in the International Classification of Diseases by the World Health Organization. Although numerous studies over time have uncovered organic abnormalities in patients with ME/CFS, and the majority of researchers to date classify the disease as organic, many physicians still believe that ME/CFS is a psychosomatic illness. In this article, we show how detrimental this belief is to the care and well-being of affected patients and, as a consequence, how important the education of physicians and the public is to stop misdiagnosis, mistreatment, and stigmatization on the grounds of incorrect psychosomatic attributions about the etiology and clinical course of ME/CFS. Full article
(This article belongs to the Special Issue Advances in ME/CFS Research and Clinical Care: Part II)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop