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Nanobiomaterials in Microbiology and Immunology

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3658

Special Issue Editors

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Guest Editor
Department of Microbiology and Immunology, University of Bucharest, Bucharest, Romania
Interests: microbiology; immunology; new antimicrobial agents; host–pathogen signaling; infection control; antimicrobial nanomaterials
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Microbiology & Immunology Department, Faculty of Biology, University of Bucharest, Soseaua Panduri nr. 90-92, Sector 5, 050663 Bucharest, Romania
Interests: biofilms and tolerance of biofilm-embedded cells; QS mechanism and QS inhibitors; antipathogenic strategies; human microbiota; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of nanobiomaterials has developed rapidly and continuously in recent years. Innovative techniques have emerged to facilitate the precise manipulation of materials at the nanoscale, providing diverse applications for the biomedical field. However, research on the intimate relations of such promising nanomaterials and complex biological systems is at its infancy. When introducing an external material into the mammalian body, the most important challenge is to determine if the body will develop an immune response. Another challenge that researchers need to face is microbial contamination and biofilm development risk, knowing that microbial adherence is in proportionally inverse ratio with the compatibility of foreign biomaterial with host tissues. It is well known that any material to be introduced into the body needs to be sterile, and accidental microbial colonization must be avoided once it is introduced into the body. In recent years, numerous antimicrobial nanosystems have been developed based on innovative materials tailored at the nanoscale, which have proven their utility in the fight against severe infections. This Special Issue aims to provide an updated collection of papers, showing the most relevant progress made in the field of development and characterization of nanobiomaterials, targeting their applications in different prosthetic or therapeutic device production with anti-inflammatory and antibiofilm properties.

Dr. Alina Maria Holban
Prof. Veronica Lazar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial nanobiomaterials
  • biofilm control
  • biocompatibility
  • immune response
  • inflammation

Published Papers (1 paper)

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16 pages, 5701 KiB  
ZnO Nanoparticles-Modified Dressings to Inhibit Wound Pathogens
by Sajjad Mohsin I. Rayyif, Hamzah Basil Mohammed, Carmen Curuțiu, Alexandra Cătălina Bîrcă, Alexandru Mihai Grumezescu, Bogdan Ștefan Vasile, Lia Mara Dițu, Veronica Lazăr, Mariana Carmen Chifiriuc, Grigore Mihăescu and Alina Maria Holban
Materials 2021, 14(11), 3084; - 4 Jun 2021
Cited by 46 | Viewed by 2942
Zinc oxide (ZnO) nanoparticles (NPs) have been investigated for various skin therapies in recent years. These NPs can improve the healing and modulate inflammation in the wounds, but the mechanisms involved in such changes are yet to be known. In this study, we [...] Read more.
Zinc oxide (ZnO) nanoparticles (NPs) have been investigated for various skin therapies in recent years. These NPs can improve the healing and modulate inflammation in the wounds, but the mechanisms involved in such changes are yet to be known. In this study, we have designed a facile ZnO nano-coated dressing with improved antimicrobial efficiency against typical wound pathogens involved in biofilm and chronic infections. ZnO NPs were obtained by hydrothermal method and characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. Antibacterial and antibiofilm effects were evaluated against laboratory and clinical isolates of significant Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and Gram-positive (Staphylococcus aureus and Enterococcus faecalis) opportunistic pathogens, by quantitative methods. Our results have shown that the developed dressings have a high antibacterial efficiency after 6–24 h of contact when containing 0.6 and 0.9% ZnO NPs and this effect is similar against reference and clinical isolates. Moreover, biofilm development is significantly impaired for up to three days of contact, depending on the NPs load and microbial species. These results show that ZnO-coated dressings prevent biofilm development of main wound pathogens and represent efficient candidates for developing bioactive dressings to fight chronic wounds. Full article
(This article belongs to the Special Issue Nanobiomaterials in Microbiology and Immunology)
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