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Applied Sciences
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Antibacterial Strategies in Biomaterials
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Antibacterial Strategies in Biomaterials

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 4337

Special Issue Editors

Dr. Mara Mădălina Mihai

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Guest Editor
1. Department of Oncologic Dermatology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Elias Emergency University Hospital, Bucharest, Romania
Interests: bioactive materials; nanotechnology; targeted therapy; biologic therapy; chronic wounds; wound healing; chronic skin infections; microbial biofilms; skin cancer; melanoma
Special Issues, Collections and Topics in MDPI journals
Dr. Alina Maria Holban

E-Mail Website
Guest Editor
Department of Microbiology and Immunology, University of Bucharest, Bucharest, Romania
Interests: microbiology; immunology; new antimicrobial agents; host–pathogen signaling; infection control; antimicrobial nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious diseases greatly impact global morbidity and mortality, with a significant economic burden. While microorganisms continuously develop new mechanisms of antimicrobial resistance, we acknowledge the limitations of available therapeutic options, especially in the case of multi-resistant strains. Novel materials with biomedical applications could offer promising perspectives, since such innovative approaches could yield efficient solutions for the global problem of infections with resistant microorganisms. Drug delivery systems such as nanostructured materials could enable a targeted antimicrobial action of natural or synthetic agents. Novel and efficient antimicrobial approaches by molecular and nanosized structures may modulate microbial virulence, host–microbiome interactions, and/or host immune responses and consequently contribute to infection control. These approaches should be focused on the endpoint, their efficiency, and their application in clinical practice, with the lowest cytotoxicity and adverse reactions.

We invite you to contribute your recent work to this Special Issue of Applied Sciences that aims to bring together the most innovative and interesting advances made in the development of biomaterials with antimicrobial properties. Research and review papers focusing on this intriguing field will be considered for this Special Issue.

Assist. Prof. Mara Mihai
Assist. Prof. Alina Maria Holban
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive materials
  • nanomaterials
  • antimicrobial delivery
  • antimicrobial materials
  • infection control
  • biofilm inhibition
  • biofilm modulation
  • antimicrobial surfaces, coatings, and devices
  • antimicrobial drug delivery systems
  • nanosystems for infection control
  • antimicrobial resistance

Published Papers (2 papers)

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Research

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16 pages, 4844 KiB  
Article
Microcalorimetry—Versatile Method of Describing Bacterial Growth
by Mihnea Ioan Gabriel Popa, Adrian Cursaru, Bogdan Serban, Bogdan Cretu, Andrei Alexandru Muntean, Vlad Tudor Popa, Mariana Carmen Chifiriuc and Cătălin Cîrstoiu
Appl. Sci. 2021, 11(20), 9740; https://doi.org/10.3390/app11209740 - 19 Oct 2021
Cited by 2 | Viewed by 1740
Abstract
(1) Background: Due to the aging population in industrialized countries and due to the increase in the number of traffic or sports accidents, the number of artificial joints and implants for osteosynthesis will increase in the coming years. Therefore, the risk of postoperative [...] Read more.
(1) Background: Due to the aging population in industrialized countries and due to the increase in the number of traffic or sports accidents, the number of artificial joints and implants for osteosynthesis will increase in the coming years. Therefore, the risk of postoperative infections will be higher as well. (2) Methods: For this study, we combined classical bacterial identification with the description of bacterial growth curves using microcalorimetry. (3) Results: We evaluated the growth of S. aureus and S. epedermidis, but we believe that this can be applied to any anaerobic or aerobic bacterial colony. We discovered that the time interval after which we can identify a growth curve does not exceed 15–20 h. (4) Conclusions: The diagnosis made by combining the methods of sonication and microcalorimetry manages to provide a great deal of information about the bacteria we studied. Microcalorimetry has real potential as a method for obtaining quick diagnosis in various cases of infection, but many more experiments need to be done to ensure the correct use of this technique. A detailed investigation (including kinetic analysis) of the reproducible thermal signal of bacterial growth can lead to the development of alternative means of rapid bacterial identification. Full article
(This article belongs to the Special Issue Antibacterial Strategies in Biomaterials)
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Review

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18 pages, 955 KiB  
Review
Novel Antimicrobials, Drug Delivery Systems and Antivirulence Targets in the Pipeline—From Bench to Bedside
by Oana Săndulescu, Ioana Viziteu, Anca Streinu-Cercel, Victor Daniel Miron, Liliana Lucia Preoțescu, Narcis Chirca, Simona Elena Albu, Mihai Craiu and Adrian Streinu-Cercel
Appl. Sci. 2022, 12(22), 11615; https://doi.org/10.3390/app122211615 - 16 Nov 2022
Cited by 1 | Viewed by 1489
Abstract
In a fast-paced medical reality, biosciences and bioengineering have become essential components in medical research and development. The aim of this paper is to characterize the recent progresses made in fighting antimicrobial resistance, particularly in relation to WHO’s priority pathogens, by providing an [...] Read more.
In a fast-paced medical reality, biosciences and bioengineering have become essential components in medical research and development. The aim of this paper is to characterize the recent progresses made in fighting antimicrobial resistance, particularly in relation to WHO’s priority pathogens, by providing an in-depth review of novel antimicrobials, drug delivery systems for targeted antimicrobial action and novel antivirulence targets. We systematically searched the ClinicalTrials.gov database to identify clinical trials targeting WHO’s priority 1 (critical) pathogens: carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant ESBL-producing Enterobacteriaceae. We identified a limited number of clinical trials, specifically for: one novel betalactamase inhibitor for Acinetobacter spp., one anti-virulence human monoclonal antibody for Pseudomonas spp. and no novel antimicrobials for carbapenem-resistant Enterobacteriaceae. We also performed a review of field literature to exemplify the main applications of drug delivery systems in infectious diseases, particularly in achieving targeted antibiotic distribution, in enhancing local activity with reduced off-target effects, triggered antibiotic release and triggered antibacterial photodynamic therapy. We conclude by presenting novel targets for antivirulence therapeutics that act by disrupting quorum sensing, inhibiting bacterial adherence and biofilm formation, silencing virulence traits and neutralizing bacterial toxins. Furthermore, the main principles of rational antimicrobial use are highlighted, in an effort to describe potential areas for targeted intervention, from diagnostic stewardship to antimicrobial stewardship. Full article
(This article belongs to the Special Issue Antibacterial Strategies in Biomaterials)
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