Special Issue "Targeted Therapies for Skin Diseases"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 880

Special Issue Editors

Department of Oncologic Dermatology—“Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: chronic wounds; wound healing; chronic skin infections; microbial biofilms; skin cancer; melanoma; bioactive materials; nanotechnology; targeted therapy; biologic therapy
Special Issues, Collections and Topics in MDPI journals
1. Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania
2. The Research Institute of the University of Bucharest, ICUB, 060023 Bucharest, Romania
Interests: biofilms and tolerance of biofilm-embedded cells; quorum sensing; antipathogenic strategies; human microbiota; probiotics bacterial pathogenesis; virulence factors; biofilms; antibacterial activity; antibiotic resistance; Staphylococcus aureus; Escherichia coli; Pseudomonas aeruginosa
Special Issues, Collections and Topics in MDPI journals
1. Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania
2. The Research Institute of the University of Bucharest, ICUB, 060023 Bucharest, Romania
3. Romanian Academy of Scientists, 050085 Bucharest, Romania
4. The Romanian Academy, 010071 Bucharest, Romania
Interests: bacterial pathogenesis; epidemiology; reservoirs; antimicrobial strategies; microbial virulence; microbial pathogenicity; virulence factors; quorum sensing; biofilms; antibacterial activity; antibiotic resistance; Staphylococcus aureus; Escherichia coli; Pseudomonas aeruginosa
Special Issues, Collections and Topics in MDPI journals
1. Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania
2. The Research Institute of the University of Bucharest, ICUB, 060023 Bucharest, Romania
Interests: microbiology; immunology; new antimicrobial agents; host-pathogen signaling; infection control; antimicrobial nanomaterials; bacterial pathogenesis; virulence factors; quorum sensing; biofilms; antibacterial activity; antibiotic resistance; Staphylococcus aureus; Escherichia coli; Pseudomonas aeruginosa; microbial molecular biology; bioactive materials; nanotechnology; nanoengineering
Special Issues, Collections and Topics in MDPI journals
Department of Oncologic Dermatology—“Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: psoriasis; inflammatory skin diseases; targeted therapy; biologic therapy; immunology
Cantacuzino National Medical Military Institute for Research and Developement, Carol Davila University of Medicine and Pharmacy, 050096 Bucharest, Romania
Interests: infectious diseases; microbiology; chronic infections; bacteriophage; microcalorimetry; tuberculosis; blood-borne pathogens
Department of Oncologic Dermatology—“Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: chronic wounds; skin cancer; melanoma; inflammatory skin diseases; targeted therapy; biologic therapy; immunology
Department of Oncologic Dermatology—“Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: skin cancer; melanoma; chronic wounds; inflammatory skin diseases; targeted therapy; biologic therapy; immunology

Special Issue Information

Dear Colleagues,

Over the last few years, the therapeutic landscape of cutaneous pathologies has changed tremendously. Novel diagnostic and therapeutic approaches have developed toward being based on observations resulting from artificial intelligence analysis, the study of biomarkers, and the identification of specific cellular and molecular pathogenic targets. With the emergence of ingenious topical and systemic targeted therapies, higher rates of healing and disease control in skin cancers, chronic infections, wound healing, and inflammatory and autoimmune diseases were achieved. On the other side, a wide range of adverse reactions have emerged (dermatologic or otherwise) that impact treatment outcomes and are difficult to manage, requiring experience and a multidisciplinary approach. Innovation of therapies should focus on the endpoint together with their efficiency and application in clinical practice, achieving the lowest possible cytotoxicity and incidence of adverse reactions.

As an editorial team with clinical and research experience in novel therapies (biologic therapy, Janus kinase inhibitors, immunotherapy, vaccines, drug delivery systems, nanotechnology, bioactive materials, transdermal drug delivery systems), we are pleased to invite you to contribute your recent work to this Special Issue, which aims to bring together the most innovative and interesting advances made in the targeted treatment of skin diseases.

Original research articles and review papers focusing on this intriguing field are welcome to be considered for publication in this Special Issue. We encourage you to submit your research, and this Special Issue may be printed in book format if 10 or more papers are published.

We look forward to receiving your contributions.

Dr.  Mara Mădălina Mihai
Prof. Dr. Veronica Lazǎr
Prof. Dr. Mariana-Carmen Chifiriuc
Dr. Alina-Maria Holban
Prof. Dr. Cǎlin Giurcǎneanu
Prof. Dr. Mircea Ioan Popa
Dr. Liliana Gabriela Popa
Dr. Cristina Beiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • targeted therapy
  • precision medicine
  • biologic therapy
  • Janus kinase inhibitors
  • immunotherapy
  • vaccines
  • drug delivery systems
  • antimicrobials
  • nanotechnology
  • bioactive materials
  • transdermal drug delivery

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Antimicrobial Biomaterials for Chronic Wound Care
Pharmaceutics 2023, 15(6), 1606; https://doi.org/10.3390/pharmaceutics15061606 - 28 May 2023
Viewed by 580
Abstract
Chronic wounds encompass a myriad of lesions, including venous and arterial leg ulcers, diabetic foot ulcers (DFUs), pressure ulcers, non-healing surgical wounds and others. Despite the etiological differences, chronic wounds share several features at a molecular level. The wound bed is a convenient [...] Read more.
Chronic wounds encompass a myriad of lesions, including venous and arterial leg ulcers, diabetic foot ulcers (DFUs), pressure ulcers, non-healing surgical wounds and others. Despite the etiological differences, chronic wounds share several features at a molecular level. The wound bed is a convenient environment for microbial adherence, colonization and infection, with the initiation of a complex host–microbiome interplay. Chronic wound infections with mono- or poly-microbial biofilms are frequent and their management is challenging due to tolerance and resistance to antimicrobial therapy (systemic antibiotic or antifungal therapy or antiseptic topicals) and to the host’s immune defense mechanisms. The ideal dressing should maintain moisture, allow water and gas permeability, absorb wound exudates, protect against bacteria and other infectious agents, be biocompatible, be non-allergenic, be non-toxic and biodegradable, be easy to use and remove and, last but not least, it should be cost-efficient. Although many wound dressings possess intrinsic antimicrobial properties acting as a barrier to pathogen invasion, adding anti-infectious targeted agents to the wound dressing may increase their efficiency. Antimicrobial biomaterials may represent a potential substitute for systemic treatment of chronic wound infections. In this review, we aim to describe the available types of antimicrobial biomaterials for chronic wound care and discuss the host response and the spectrum of pathophysiologic changes resulting from the contact between biomaterials and host tissues. Full article
(This article belongs to the Special Issue Targeted Therapies for Skin Diseases)
Show Figures

Figure 1

Back to TopTop