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Marine Drugs
Special Issues
Advances in Medicinal Research of Phlorotannins
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Advances in Medicinal Research of Phlorotannins

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 10961

Special Issue Editors

Prof. Dr. Seon-Heui Cha

E-Mail Website
Guest Editor
Department of Marine Biomedical Sciences, Hanseo University, Chungcheongman-do 31962, Korea
Interests: oxidative stress; antioxidant activity; hepatic inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Lei Wang

E-Mail Website
Guest Editor
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
Interests: marine natural products; human health; skin aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Brown algae are a relatively high-level group of seaweeds, with the characteristics of large individuals, high yields, and wide distribution. In the past 20 years, with the in-depth research on phlorotannins, brown algae’s secondary metabolites, its unique biological activity has attracted increasing attention. Phlorotannins are a type of tannin found in brown algae such as kelps, rockweeds, etc. Many recent reports have indicated that phlorotannins have important effects on human nutrition and health. Because of its broad biological activities (antioxidant, antibacterial, antiviral, anti-tumor, anti-cardiovascular disease, anti-diabetic syndrome, liver protection, etc.) it is of great significance to the development of marine drugs.

The aim of this Special Issue is to gather new information regarding the novel discovery and medicinal, pharmaceutical and nutraceutical applications of phlorotannins. Scientists who work in the research of phlorotannins are highly welcome to contribute research articles and reviews.

Prof. Dr. Seon-Heui Cha
Prof. Dr. Lei Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phlorotannins
  • marine natural products
  • brown algae
  • polyphenols
  • phenols
  • antioxidant
  • oxidative stress
  • antibacterial
  • antitumor
  • anti-diabetic syndrome
  • nutraceutical

Published Papers (4 papers)

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Research

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8 pages, 1751 KiB  
Article
Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
by Lei Wang, Jun-Geon Je, Hyun-Soo Kim, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao and You-Jin Jeon
Mar. Drugs 2022, 20(9), 557; https://doi.org/10.3390/md20090557 - 30 Aug 2022
Cited by 2 | Viewed by 1599
Abstract
Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In order to evaluate the cosmeceutical potential of [...] Read more.
Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In order to evaluate the cosmeceutical potential of EME-EA, the anti-melanogenesis and photoprotective effects of EME-EA were investigated in this study. EME-EA remarkably inhibited mushroom tyrosinase and melanogenesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EME-EA significantly suppressed UVB-induced HaCaT cell death that was consistent with inhibition of apoptosis and reduction in scavenging intracellular reactive oxygen species. Furthermore, EME-EA significantly inhibited collagen degradation and matrix metalloproteinases expression in UVB-irradiated HDF cells in a concentration-dependent manner. These results indicate that EME-EA possesses strong anti-melanogenesis and photoprotective activities and suggest EME-EA is an ideal ingredient in the pharmaceutical and cosmeceutical industries. Full article
(This article belongs to the Special Issue Advances in Medicinal Research of Phlorotannins)
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17 pages, 3059 KiB  
Article
Therapeutic Potential of Phlorotannin-Rich Ecklonia cava Extract on Methylglyoxal-Induced Diabetic Nephropathy in In Vitro Model
by Chi-Heung Cho, Chang-Jun Lee, Min-Gyeong Kim, Bomi Ryu, Jun-Geon Je, Yoonsook Kim and Sang-Hoon Lee
Mar. Drugs 2022, 20(6), 355; https://doi.org/10.3390/md20060355 - 27 May 2022
Cited by 6 | Viewed by 2254
Abstract
Advanced glycation end-products (AGEs) play a vital role in the pathogenesis of diabetic complications. Methylglyoxal (MGO), one of the major precursors of AGEs, is a highly reactive dicarbonyl compound that plays an important role in the pathogenesis of diabetic nephropathy. This study was [...] Read more.
Advanced glycation end-products (AGEs) play a vital role in the pathogenesis of diabetic complications. Methylglyoxal (MGO), one of the major precursors of AGEs, is a highly reactive dicarbonyl compound that plays an important role in the pathogenesis of diabetic nephropathy. This study was designed to evaluate the therapeutic potential of phlorotannin-rich Ecklonia cava extract (ECE) on MGO-induced diabetic nephropathy in in vitro models using mouse glomerular mesangial cells. ECE showed anti-glycation activity via breaking of AGEs-collagen cross-links and inhibition of AGEs formation and AGE-collagen cross-linking formation. The renoprotective effects were determined by assessing intracellular reactive oxygen species (ROS) and MGO accumulation, cell apoptosis, and the Nrf-2/ARE signaling pathway. MGO-induced renal damage, intracellular ROS production level, and MGO-protein adduct accumulation were significantly decreased by pretreating ECE. Moreover, ECE pretreatment exhibited preventive properties against MGO-induced dicarbonyl stress via activation of the Nrf2/ARE signaling pathway and reduction of RAGE protein expression in mouse glomerular mesangial cells. Collectively, these results indicated potential anti-glycation properties and prominent preventive effects of ECE against MGO-induced renal damage. Additionally, ECE may be utilized for the management of AGE-related diabetic nephropathy. Full article
(This article belongs to the Special Issue Advances in Medicinal Research of Phlorotannins)
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Review

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30 pages, 1054 KiB  
Review
A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins
by Hongli Zheng, Yanan Zhao and Lei Guo
Mar. Drugs 2022, 20(12), 742; https://doi.org/10.3390/md20120742 - 26 Nov 2022
Cited by 18 | Viewed by 3090
Abstract
Phlorotannins are a type of natural active substance extracted from brown algae, which belong to a type of important plant polyphenol. Phloroglucinol is the basic unit in its structure. Phlorotannins have a wide range of biological activities, such as antioxidant, antibacterial, antiviral, anti-tumor, [...] Read more.
Phlorotannins are a type of natural active substance extracted from brown algae, which belong to a type of important plant polyphenol. Phloroglucinol is the basic unit in its structure. Phlorotannins have a wide range of biological activities, such as antioxidant, antibacterial, antiviral, anti-tumor, anti-hypertensive, hypoglycemic, whitening, anti-allergic and anti-inflammatory, etc. Phlorotannins are mainly used in the fields of medicine, food and cosmetics. This paper reviews the research progress of extraction, separation technology and biological activity of phlorotannins, which will help the scientific community investigate the greater biological significance of phlorotannins. Full article
(This article belongs to the Special Issue Advances in Medicinal Research of Phlorotannins)
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27 pages, 2768 KiB  
Review
Molecular Targets of Brown Algae Phlorotannins for the Therapy of Inflammatory Processes of Various Origins
by Natalya N. Besednova, Boris G. Andryukov, Tatyana S. Zaporozhets, Tatyana A. Kuznetsova, Sergey P. Kryzhanovsky, Svetlana P. Ermakova, Irina V. Galkina and Mikhail Yu. Shchelkanov
Mar. Drugs 2022, 20(4), 243; https://doi.org/10.3390/md20040243 - 30 Mar 2022
Cited by 19 | Viewed by 3197
Abstract
Inflammatory reactions are part of a complex biological response that plays a vital role in the appearance of various stimuli resulting from tissue and cell damage, the invasion of pathogenic bacteria, and the formation of the subsequent adaptive immune response. The production of [...] Read more.
Inflammatory reactions are part of a complex biological response that plays a vital role in the appearance of various stimuli resulting from tissue and cell damage, the invasion of pathogenic bacteria, and the formation of the subsequent adaptive immune response. The production of many triggers and mediators of inflammation, which are inducers of pro-inflammatory factors, is controlled by numerous differentiation programs, through which inflammation is resolved and tissue homeostasis is restored. However, prolonged inflammatory responses or dysregulation of pro-inflammatory mechanisms can lead to chronic inflammation. Modern advances in biotechnology have made it possible to characterize the anti-inflammatory activity of phlorotannins, polyphenolic compounds from brown seaweed, and the mechanisms by which they modulate the inflammatory response. The purpose of this review is to analyze and summarize the results of numerous experimental in vitro and in vivo studies, illustrating the regulatory mechanisms of these compounds, which have a wide range of biological effects on the body. The results of these studies and the need for further research are discussed. Full article
(This article belongs to the Special Issue Advances in Medicinal Research of Phlorotannins)
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