Special Issue "Marine Bioactive Substances: Implicated with Senescence-Related Disease"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 86

Special Issue Editor

Department of Marine Bio and Medical Sciences, Hanseo University, Seosan 32158, Republic of Korea
Interests: nutraceuticals; cosmeceuticals; functional materials; marine biofoods; marine drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the increase in life expectancy, the aging population around the globe has been growing significantly. Cellular senescence has been indicated as one of the molecular processes involved in age-related diseases, including cardiovascular diseases, cancer, neurodegenerative diseases and diabetes, which has become a primary health issue challenging the health care system worldwide. During the last decades, internal and external causes of senescence have been characterized, such as organelle deterioration and the senescence-associated secretory phenotype (SASP), a cellular phenotype characterized by an increased expression and secretion of proinflammatory cytokines and chemokines. Moreover, oxidative stress has been shown to play an important role in exacerbating senescence by promoting the accumulation of reactive oxygen and nitrogen species and disrupting protein turnover.

 The continuous accumulation of senescent cells leads to the age-related deterioration of vital organs, and thus constitutes an organism's aging process. Correspondingly, the therapeutic removal of the senescent cells can improve health and prolong the lifespan.

The majority of anti-aging research has been investigating metabolic pathways associated with senescence to define therapeutic strategies to slow the progressive decline of age-related pathologies. Among these strategies, a balanced diet, including antioxidant phytochemicals and a healthy lifestyle, have also been described to have beneficial effects in fighting aging and its related disorders.

A nutrient-dense diet with micro- and macro-algae, as well as fish and shellfish containing micronutrients such as vitamins, carotenoids, peptides and other phytochemicals that protect against senescence-related diseases, has been linked to improved health and longevity. Marine phytochemicals, which are secondary metabolites made by macro- and micro-algae to defend themselves from infections and UV damage, are probably the most researched marine natural chemical. Phenolic acids and flavonoids are bioactive chemicals. Numerous phytochemicals have been identified that extend the lifespan in experimental organisms, implying a clear relationship between polyphenol consumption and longevity.

We would like to invite scientists to participate in this Special Issue by submitting an updated and new base of knowledge on the isolation, identification and applications of marine source not only polyphenol, but also polysaccharides and peptides.

Potential topics include, but are not limited to the following:

  • Antiaging, antidiabetic, antiobesity, anti-Alzheimer’s disease, anti-Parkinson’s disease and anti-vascular disease effects of marine bio matrials;
  • In vivo and in vitro studies focused on the mechanisms underlying oxidative stress and cellular senescence-related disease and the therapeutic effects of marine bioactives;
  • Marine bioactive compounds regulating cellular senescence-related disease.

Dr. Seon-Heui Cha
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • senescence
  • senescence-related disease
  • aging
  • Alzheimer’s disease
  • Parkinson’s disease
  • diabetes
  • obesity
  • vascular disease

Published Papers

This special issue is now open for submission.
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