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Functions and Applications of Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 867

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Engineering and Medical Science, Soonchunhyang University, Asan 31538, Republic of Korea
Interests: bioactive natural products; nutraceuticals; cosmeceuticals; pharmaceuticals

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Guest Editor
Department of Marine Bio and Medical Sciences, Hanseo University, Seosan 32158, Republic of Korea
Interests: nutraceuticals; cosmeceuticals; functional materials; marine biofoods; marine drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural products have a wide range of possible applications, such as biomedicine and pharmacotherapy, and they can be useful in the treatment and management of various kinds of human diseases due to their outstanding biological properties. Moreover, bioactive compounds and pharmaceuticals derived from natural products have received increasing attention due to their considerable benefits for human health. This Special Issue will shape the future research direction of important natural products, as well as related bioactives. Our purpose is to feature high-quality, advanced research and knowledge contributed by various research groups working on natural products from all around the world. This Special Issue invites researchers to contribute reviews and original research reports of their recent work on the functional and medicinal properties of natural products.

This Special Issue will include recent advances in natural products with significant potential benefits for human health, including the following topics: natural products for preventing and managing human diseases; the importance of nutraceuticals and cosmeceuticals derived from natural products for human health and skin aging; bioactivity and mechanism of action of natural products; new strategies of using natural drugs for promoting human health; biotechnology for yielding bioactive components from the natural products.

Dr. Seung-Hong Lee
Dr. Seon-Heui Cha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • natural products
  • biomedicine/phytomedicine
  • biologically active extracts and compounds
  • pharmacological and toxicological mechanisms of action

Published Papers (1 paper)

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Research

28 pages, 15021 KiB  
Article
Bacillus megaterium: Evaluation of Chemical Nature of Metabolites and Their Antioxidant and Agronomics Properties
by Anna Hur, Mohamed Marouane Saoudi, Hicham Ferhout, Laila Mzali, Patricia Taillandier and Jalloul Bouajila
Int. J. Mol. Sci. 2024, 25(6), 3235; https://doi.org/10.3390/ijms25063235 - 12 Mar 2024
Viewed by 593
Abstract
Bacillus megaterium is particularly known for its abundance in soils and its plant growth promotion. To characterize the metabolites excreted by this specie, we performed successive liquid/liquid extractions from bacteria culture medium with different polarity solvents (cyclohexane, dichloromethane, ethyl acetate and butanol) to [...] Read more.
Bacillus megaterium is particularly known for its abundance in soils and its plant growth promotion. To characterize the metabolites excreted by this specie, we performed successive liquid/liquid extractions from bacteria culture medium with different polarity solvents (cyclohexane, dichloromethane, ethyl acetate and butanol) to separate the metabolites in different polarity groups. The extracts were characterized regarding their total phenolic content, the amount of reducing sugar, the concentration of primary amines and proteins, their chromatographic profile by HPLC-DAD-ELSD and their chemical identification by GC-MS. Among the 75 compounds which are produced by the bacteria, 19 identifications were for the first time found as metabolites of B. megaterium and 23 were described for the first time as metabolites in Bacillus genus. The different extracts containing B. megaterium metabolites showed interesting agronomic activity, with a global inhibition of seed germination rates of soya, sunflower, corn and ray grass, but not of corn, compared to culture medium alone. Our results suggest that B. megaterium can produce various metabolites, like butanediol, cyclic dipeptides, fatty acids, and hydrocarbons, with diverse effects and sometimes with opposite effects in order to modulate its response to plant growth and adapt to various environmental effects. These findings provide new insight into bioactive properties of this species for therapeutic uses on plants. Full article
(This article belongs to the Special Issue Functions and Applications of Natural Products)
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