Special Issue "Bioactive Secondary Metabolites of Marine Fungi 2.0"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 1689

Special Issue Editor

Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea
Interests: marine natural products; biomedical applications; drug discovery; anticancer compounds; anti-inflammatory compounds; antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

Fungi represent a significant proportion of the microbial diversity on Earth. The discovery of new secondary metabolites from marine fungi has increased dramatically over the last few decades, cumulating in over 1000 new metabolites. The biosynthesis of these metabolites is dependent on ecological, physical and biological factors and, therefore, small changes in these conditions can generate an entirely new set of metabolites. Thus, understanding the chemical language of marine fungi and the development of new culture techniques are needed to discover novel fungal metabolites with potent biological activities.

Based on the success of the Special Issue “Bioactive Secondary Metabolites of Marine Fungi” (https://www.mdpi.com/journal/marinedrugs/special_issues/MarineFungi2022), as well as the critical relevance of this topic, we are pleased to announce the second edition of this Special Issue.

This Special Issue will highlight the marine fungal natural products as potential molecules for the discovery of new drugs, empathizing the structural diversity and bioactivities of marine fungal secondary metabolites.

As a Guest Editor for this Special Issue, I invite you to submit your research results on marine fungi, ranging from the isolation and structure elucidation of new natural products to biosynthetic pathways of marine fungal metabolites.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungi
  • secondary metabolites
  • structure determination
  • bioactive compounds
  • fungal diversity
  • natural products
  • therapeutic agents
  • novel compounds

Published Papers (2 papers)

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Research

12 pages, 1985 KiB  
Article
Secondary Metabolites from the Coral-Derived Fungus Aspergillus austwickii SCSIO41227 with Pancreatic Lipase and Neuraminidase Inhibitory Activities
Mar. Drugs 2023, 21(11), 567; https://doi.org/10.3390/md21110567 - 29 Oct 2023
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Abstract
The coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf yielded four previously uncharacterized compounds, namely asperpentenones B–E (14), along with twelve known compounds (516). Their structures were elucidated using HRESIMS and NMR (1H [...] Read more.
The coral-derived fungus Aspergillus austwickii SCSIO41227 from Beibu Gulf yielded four previously uncharacterized compounds, namely asperpentenones B–E (14), along with twelve known compounds (516). Their structures were elucidated using HRESIMS and NMR (1H and 13C NMR, HSQC, HMBC), among which the stereo-structure of compounds 13 was determined by calculated ECD. Furthermore, compounds 116 were evaluated in terms of their enzyme (acetylcholinesterase (AChE), pancreatic lipase (PL), and neuraminidase (NA)) inhibitory activities. These bioassay results revealed that compounds 2 and 14 exerted noticeable NA inhibitory effects, with IC50 values of 31.28 and 73.64 μM, respectively. In addition, compound 3 exhibited a weak inhibitory effect against PL. Furthermore, these compounds showed the potential of inhibiting enzymes in silico docking analysis to demonstrate the interactions between compounds and proteins. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi 2.0)
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11 pages, 1612 KiB  
Article
The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
Mar. Drugs 2023, 21(11), 566; https://doi.org/10.3390/md21110566 - 28 Oct 2023
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Abstract
Five new polyketides, including two chromones (12), two phenyl derivatives (45), and a tandyukusin derivative (6), along with five known polyketides (3 and 710) were isolated from mangrove endophytic [...] Read more.
Five new polyketides, including two chromones (12), two phenyl derivatives (45), and a tandyukusin derivative (6), along with five known polyketides (3 and 710) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds were elucidated via detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, and alkali hydrolysis were applied in the determination of the absolute configuration of the new compounds. In bioassays, 6 and 9 exhibited promising antifungal activities against Penicillium italicum, with an MIC value of 6.25 μM for both compounds. Moreover, 3 displayed moderate AChE inhibitory activity with an IC50 value of 20.6 ± 0.3 μM. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi 2.0)
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