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Marine Drugs
Special Issues
Glycosylated Metabolites from Marine Bacteria
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Glycosylated Metabolites from Marine Bacteria

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4454

Special Issue Editor

Prof. Dr. Hee Jae Shin

E-Mail Website
Guest Editor
Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea
Interests: marine natural products; biomedical applications; drug discovery; anticancer compounds; anti-inflammatory compounds; antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Glycosylation of naturally occurring and synthetic small molecule drugs can dramatically influence the pharmacological and/or pharmacokinetic properties of the parent scaffold. Among bacterial secondary metabolites, about 20% are glycosides wherein glycosylated macrolides and macrolactams represent the largest allocation. Many marine bacteria use glycosylated small molecules for chemical defense to have selective advantages or as signaling molecules for intra- and interspecies communication.

As Guest Editor for this Special Issue, I sincerely invite you to submit your research findings on marine bacteria on the isolation and structure elucidation of new glycosylated secondary metabolites as well as biosynthetic pathways of marine glycosylated metabolites.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine bacteria
  • secondary metabolites
  • glycosylation
  • marine microorganisms
  • novel therapeutic agents
  • bioactive compounds

Published Papers (3 papers)

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Research

15 pages, 3165 KiB  
Article
Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine Bacillus sp.
by Jinsheng Cui, Suhyun Ye, Daniel Shin, Illhwan Cho, Hye Yun Kim, Yun Kwon, Keunwan Park, Sang-Jip Nam, YoungSoo Kim and Dong-Chan Oh
Mar. Drugs 2023, 21(2), 67; https://doi.org/10.3390/md21020067 - 19 Jan 2023
Cited by 2 | Viewed by 1601
Abstract
Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were [...] Read more.
Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher’s method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid β (Aβ) aggregation, whereas succinyl macrolactin O (2) inhibited Aβ aggregation, indicating their therapeutic potential for disassembling and removing Aβ aggregation. Full article
(This article belongs to the Special Issue Glycosylated Metabolites from Marine Bacteria)
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10 pages, 1384 KiB  
Article
Actinoflavosides B–D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces
by Hyeongju Jeong, Se Jin Jo, Munhyung Bae, Young Ran Kim and Kyuho Moon
Mar. Drugs 2022, 20(9), 565; https://doi.org/10.3390/md20090565 - 05 Sep 2022
Cited by 3 | Viewed by 1728
Abstract
Three new secondary metabolites, actinoflavosides B–D (1–3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were [...] Read more.
Three new secondary metabolites, actinoflavosides B–D (1–3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by J-based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher’s method. Actinoflavosides B–D (1–3) displayed antibacterial activity against Pseudomonas aeruginosa, and actinoflavoside D (3) significantly increased IL-2 production in mouse splenocytes. Full article
(This article belongs to the Special Issue Glycosylated Metabolites from Marine Bacteria)
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Figure 1

8 pages, 633 KiB  
Article
New Glycosylated Secondary Metabolites from Marine-Derived Bacteria
by Cao Van Anh, Jong Soon Kang, Hwa-Sun Lee, Phan Thi Hoai Trinh, Chang-Su Heo and Hee Jae Shin
Mar. Drugs 2022, 20(7), 464; https://doi.org/10.3390/md20070464 - 20 Jul 2022
Cited by 2 | Viewed by 1988
Abstract
Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus [...] Read more.
Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1–3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1–3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI50 values ranging from 8.0 to 10.9 µM. Full article
(This article belongs to the Special Issue Glycosylated Metabolites from Marine Bacteria)
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