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Special Issue "Orthodontics and Oral Surgery in Personalized Medicine"

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A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 10 January 2024 | Viewed by 5242

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Special Issue Editors

Dr. Angelo Michele Inchingolo

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Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Interests: stem cells regeneration tissue; dental disease; dental biomaterials; orthodontic diseases; orthodontic innovation; oral surgery
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Prof. Dr. Francesco Inchingolo

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Guest Editor

Dr. Gianna Dipalma

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Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: stem cells regeneration tissue; dental disease; dental biomaterials; orthodontic diseases; orthodontic innovation; oral surgery
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Dr. Assunta Patano

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Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: orthodontics; pediatric dentistry; oral medicine; oropharyngeal neoplasms; hygiene; prevention
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Dr. Giuseppina Malcangi

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Guest Editor

Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: stem cells regeneration tissue; dental disease; dental biomaterials; orthodontic diseases; orthodontic innovation; oral surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our utmost pleasure to invite you to submit manuscripts to one of the most current topics in dentistry: “Orthodontics and Oral Surgery in Personalized Medicine”.

The future of orthodontics and oral surgery is influenced by the advent of digital technology and the change in expectations of our patients. A modern approach often requires interdisciplinary and multidisciplinary know-how, the use of digital technologies for treatment planning to enhance the predictability of the execution, and a comprehensive team approach. New technologies can help in reducing the invasiveness of clinical procedures.

New computer technologies will revolutionize research, diagnosis, treatment, and education in dentistry.

Oral surgery, implants, periodontology and orthodontics are all involved in this continuing evolution.

This Special Issue focuses on all of the recent technology that can enhance research, diagnosis, treatment, and education in dentistry. For this purpose, we invite you to submit original research articles, clinical articles, and reviews on any of the topics mentioned above.

The present Special Issue will focus on clinically and scientifically valuable research in dentistry and allied disciplines in order to provide evidence-based information that will contribute to a better understanding and implementation of cutting-edge, patient-centered, and tailored treatment options.

We look forward to receiving your submissions.

Dr. Angelo Michele Inchingolo
Prof. Dr. Francesco Inchingolo
Dr. Gianna Dipalma
Dr. Assunta Patano
Dr. Giuseppina Malcangi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oral surgery
orthodontic
aligners
maxillo facial surgery
dental disease
dental materials
orthodontic diseases
periodontology
oral implantology
dental materials
regenerative tissue
growth factor
stem cells
bone regeneration
tissue regeneration
engineering
intraoral scan
personalized medicine

Published Papers (6 papers)

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Research

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Open AccessArticle

Retrospective Analysis of the Airway Space Changes in Dentofacial Deformity after Two-Jaw Orthognathic Surgery Using Cone Beam Computed Tomography

and

J. Pers. Med. 2023, 13(8), 1256; https://doi.org/10.3390/jpm13081256 - 14 Aug 2023

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Abstract

Orthognathic surgery is used to modify anomalies in maxillomandibular position; this process can significantly affect the anatomy of the airway and cause functional changes. This study aims to define the impact of mandibular maxillary movement on the airway of subjects with dentofacial deformity. A retrospective study was conducted on subjects with Angle class II (CII group) and Angle class III (CIII group) dentofacial deformities. The subjects were treated via bimaxillary surgery; for all of them, planning was performed with software and 3D printing. Cone beam computed tomography (CBCT) was obtained 21 days before surgery and 6 months after surgery and was used for planning and follow-up with the same conditions and equipment. Was used the superimposition technique to obtain the maximum and minimum airway areas and total airway volume. The data were analyzed with the Shapiro–Wilk test and Student’s t-test, while Spearman’s test was used to correlate the variables, considering a value of p < 0.05. Thus, 76 subjects aged 18 to 55 years (32.38 ± 10.91) were included: 46 subjects were in CII group, treated with a maxillo-mandibular advancement, and 30 subjects were in the CIII group, treated with a maxillary advancement and a mandibular setback. In the CII group, a maxillary advancement of +2.45 mm (±0.88) and a mandibular advancement of +4.25 mm (±1.25) were observed, with a significant increase in all the airway records. In the CIII group, a maxillary advancement of +3.42 mm (±1.25) and a mandibular setback of −3.62 mm (±1.18) were noted, with no significant changes in the variables measured for the airway (p > 0.05). It may be concluded that maxillo-mandibular advancement is an effective procedure to augment the airway area and volume in the CII group. On the other hand, in subjects with mandibular prognathism and Angle class III operated with the maxillary advancement and mandibular setback lower than 4 mm, it is possible to not reduce the areas and volume in the airway. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

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Open AccessArticle

Malocclusion and Scoliosis: Is There a Correlation?

Rodolfo Francesco Mastrapasqua

Alessio Pirino

and

Fabio Scoppa

J. Pers. Med. 2023, 13(8), 1249; https://doi.org/10.3390/jpm13081249 - 10 Aug 2023

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Abstract

Introduction: Scoliosis is a complex three-dimensional malformation of the spine. Although its etiology is still being investigated, it is clear that a number of factors can influence this syndrome. The spinal deformity of idiopathic scoliosis can be viewed from an etiopathogenetic perspective as a symptom of a complicated condition with a multifactorial etiology. Numerous studies have established its relationship with malocclusion, but it is still unclear how these factors interact. Malocclusion is a change in the physiological alignment of the upper and lower teeth that can be either dental or skeletal in origin. This study’s objective is to assess the relationship between scoliosis and malocclusion. Material and Methods: A total of 646 patients were enrolled (554 females and 92 males), 447 with scoliosis and 199 without, from private dental and orthopedic practices, to answer an anonymous questionnaire. They were selected in private dental and orthopedic practices where they had dental and orthopedic examinations. Twenty-two patients were excluded because of a lack of answers. Participants were given a bilingual survey, in English and Italian, composed of 13 questions formulated specifically for this study, using Google Forms (Google LLC, Mountain View, CA, USA). Results: Univariate analysis of the question “Do you have scoliosis?” shows a significant correlation with the following questions: “Was scoliosis a family issue?” (p < 0.05 OR 7.30 IC: 3.05–17.46) “Do you have malocclusion?” (p < 0.05, OR: 1.19 IC:1.0–1.34) and “Was mal-occlusion a family issue?” (p < 0.01, OR: 1.39 IC 1.10–1.77). Performing a multivariate analysis for the same variables, the best predictors of scoliosis were “Was scoliosis a family issue?” (p < 0.001) and “Was malocclusion a family issue?” (p < 0.05), while the question “Do you have malocclusion” lost significance. Conclusion: This study adds further confirmation that there might be an important connection between malocclusion and scoliosis; it suggests that dentists and orthopedists have to check, as early as possible, for the probable presence of both pathologies to avoid a severe progression which, in most cases, may require significant therapy and even surgery. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

Open AccessArticle

A Newly Developed Orthodontic-Logopedic Screening Procedure for Myofunctional Dysfunctions—A Pilot Study

Christoph-Ludwig Hennig

and

J. Pers. Med. 2023, 13(8), 1248; https://doi.org/10.3390/jpm13081248 - 10 Aug 2023

Viewed by 364

Abstract

Interdisciplinary, patient-specific cooperation between orthodontics and speech therapy plays an important role in the therapy of myofunctional dysfunctions. The following orthodontic-logopedic screening procedure is intended to objectify the diagnosis of such dysfunctions and the progress of therapy. A diagnostic questionnaire was prepared based on existing diagnostic questionnaires for myofunctional dysfunction. It contains 32 questions, with a clinical weighting of 0 to 50 points in total. This results in a point score. The lower the score is, the lower the need for therapy is. The study included 108 patients between the ages of 6 and 50 years. After screening, the patient population was divided into Group 0 (score < 15; no speech therapy need; n = 36) and Group 1 (score ≥ 15; a speech therapy need; n = 72). Group 1 was additionally randomized into Subgroups A (with speech therapy; n = 36) and B (without speech therapy; n = 36). After a treatment interval of 6 months, all patients in Group 1 were examined again with the help of the screening procedure. Statistical analysis (SPSS) and significance testing (Mann–Whitney U test) were performed. At baseline, there was no significant difference between patients in Subgroups A and B (p = 0.157). Subgroup A had a median score of 25, and Subgroup B had a median score of 30. However, after the treatment interval, a significant improvement (p = 0.001) for Subgroup A with a median score of 11 (mean score difference = 14.67) over Subgroup B with a median score 23 (mean score difference of 7.08) was observed. The developed screening procedure was shown to be equally applicable to all patients and treatment providers. With the help of the scores in point form, the need for speech therapy and the progress of such therapy can be objectified. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

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Open AccessArticle

Upper Airway Changes and OSAS Risk in Patients after Mandibular Setback Surgery to Treat III Class Skeletal Malocclusion

Rodolfo Francesco Mastrapasqua

and

J. Pers. Med. 2023, 13(7), 1105; https://doi.org/10.3390/jpm13071105 - 07 Jul 2023

Viewed by 568

Abstract

Introduction: Mandibular setback surgery (MSS) is one of the treatment options to resolve mandibular prognathism in patients suffering from skeletal class III malocclusion, which cannot be treated with simple orthodontic treatment. The mandibular setback surgical operation can involve changes in the pharyngeal morphology, resulting in a narrowing of the posterior airway space (PAS). This aspect is associated with an increase in airflow resistance, which increases the risk of developing snoring or obstructive sleep apnea syndrome (OSAS). The aim of this study is to evaluate the medium- and long-term effects of mandibular setback surgery on the upper airways and its possible association with OSAS in patients suffering from class III skeletal malocclusion. Material and methods: A total of 12 patients (5 males and 7 females) were enrolled in this study. The statistical tests highlighted a significant change in the PAS and BMI values in relation to T0, before surgery (PAS: 12.7 SD: 1.2; BMI: 21.7 SD: 1.2), and T1, after surgery (PAS: 10.3 SD: 0.6, p < 0.01; BMI: 23.8 SD: 1.2, p < 0.05). Sample size was calculated to detect an effect size of 0.9, with statistical power set at 0.8 and the significance level set at 0.05. Results: No statistically significant correlation was found between the extent of mandibular setback, PAS and BMI change. Conclusion: This study confirms the effects of mandibular setback surgery on the upper airways, reporting a statistically significant PAS reduction in the medium- and long-term follow-up. On the other hand, no direct correlation was identified with OSAS risk, at least for the small mandibular setback (<8 mm), despite the statistically significant increase in BMI. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

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Open AccessArticle

RA.DI.CA. Splint Therapy in the Management of Temporomandibular Joint Displacement without Reduction

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J. Pers. Med. 2023, 13(7), 1095; https://doi.org/10.3390/jpm13071095 - 03 Jul 2023

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Abstract

Background: The purpose of this study is to report clinical and instrumental changes after RA.DI.CA splint therapy for temporomandibular joint disc displacement without reduction. Methods: Subjects affected by disc dislocation without reduction were recruited between July 2020 and May 2022 based on inclusion and exclusion criteria and treated with RA.DI.CA. splints over a period of 6 months. Clinical data were collected at each phase of the study (T0, T1, T2). Magnetic resonance imaging and electrognathography data were recorded at the beginning (T0) and at the end (T2) of the study. ANOVA with post-hoc contrasts was performed to assess differences in outcome measures over time. The Wilcoxon test was used to evaluate changes in disc-condyle angle between before- and after-treatment MRI. A two-tailed value of p < 0.05 was regarded as significant. Methods: Ten patients completed the study. There were statistically significant differences over time for arthralgia, headache, neck pain, and mouth opening. Disc recapture and an improved quality of mandibular movement were recorded in 70% of subjects. The clinical and instrumental improvements are probably due to the orthopedic action of RA.DI.CA splint treatment, which allows for a greater degree of joint mobilization. Conclusions: The purpose of this therapy is to recover the disc position if possible and achieve an adequate joint functional adaptation that avoids the progression of the structural damage and the recurrence of symptoms. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

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Review

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Open AccessReview

Mandibular Crowding: Diagnosis and Management—A Scoping Review

Assunta Patano

Giuseppina Malcangi

Alessio Danilo Inchingolo

Gianluca Martino Tartaglia

Marco Dolci

Gianna Dipalma

and

Angelo Michele Inchingolo

J. Pers. Med. 2023, 13(5), 774; https://doi.org/10.3390/jpm13050774 - 29 Apr 2023

Cited by 1 | Viewed by 1726

Abstract

Background: Crowding is the most frequent malocclusion in orthodontics, with a strong hereditary tendency. It already occurs in pediatric age and is mainly hereditary. It is a sign of a lack of space in the arches, and is not self-correcting, but can worsen over time. The main cause of the worsening of this malocclusion is a progressive and physiological decrease in the arch perimeter. Methods: To identify relevant studies investigating the most common possible treatments for mandibular dental crowding, a comprehensive search of PubMed, Scopus and Web of Science was conducted encompassing the last 5 years (2018–2023) using the following MeSH: “mandibular crowding AND treatment” and “mandibular crowding AND therapy “. Results: A total of 12 studies were finally included. An orthodontic treatment cannot ignore the concept of “guide arch”, which concerns the lower arch, because of the objective difficulty in increasing its perimeter; the bone structure of the lower jaw is more compact than that of the upper one. Its expansion, in fact, is limited to a slight vestibularization of the incisors and lateral sectors that may be associated with a limited distalization of the molars. Conclusions: There are various therapeutic solutions available to the orthodontist, and a correct diagnosis through clinical examination, radiographs and model analysis are essential. The decision of how to deal with crowding cannot be separated from an overall assessment of the malocclusion to be treated. Full article

(This article belongs to the Special Issue Orthodontics and Oral Surgery in Personalized Medicine)

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