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Dear Colleagues,

The recent insights into biomedicine and vector interactions between SARS-CoV-2 and host have helped to increase the efficacy of protocols and innovative treatments to combat the viral infection. The innovations of therapies and supplements can provide a sensible amelioration of the prognosis of patients experiencing severe disease as well as long-haulers. The pandemic has also led to an increase in telemedicine applications, biosensors and diagnostic tools in order to produce consistent progress in biotechnology and pharmacology due to increased prevention capabilities and reduced pressure on healthcare systems.

The scope of this Special Issue is to investigate the recent insights in biomedicine and drug therapies, adjuvant treatments, telemedicine, as well as diagnostic and prevention tools against SARS-CoV-2.

The Special Issue will consider for publication in vivo original research in human and animal studies, in vitro cell studies, biomolecular analyses and reviews.

Dr. Giuseppina Malcangi
Dr. Biagio Rapone
Dr. Alessio Danilo Inchingolo
Dr. Ioana-Roxana Bordea
Dr. Antonio Gnoni
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Keywords

SARS-CoV-2
COVID-19
human coronavirus
drug administration
vaccines
diagnostic tools
telemedicine

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11 pages, 1938 KiB

Open AccessArticle

Iatrogenic Barotrauma in COVID-19-Positive Patients: Is It Related to the Pneumonia Severity? Prevalence and Trends of This Complication Over Time

by Nicola Maggialetti, Stefano Piemonte, Emanuela Sperti, Francesco Inchingolo, Sabrina Greco, Nicola Maria Lucarelli, Pierluigi De Chirico, Stefano Lofino, Federica Coppola, Claudia Catacchio, Anna Maria Gravili, Angela Sardaro and Amato Antonio Stabile Ianora

Biomedicines 2022, 10(10), 2493; https://doi.org/10.3390/biomedicines10102493 - 06 Oct 2022

Cited by 2 | Viewed by 1627

Abstract

COVID-19 has attracted worldwide attention ever since the first case was identified in Wuhan (China) in December 2019 and was classified, at a later time, as a public health emergency of international concern in January 2020 and as a pandemic in March 2020. The interstitial pneumonia caused by COVID-19 often requires mechanical ventilation, which can lead to pulmonary barotrauma. We assessed the relationship between pneumonia severity and the development of barotrauma in COVID-19-positive patients mechanically ventilated in an intensive care unit; we therefore analyzed the prevalence of iatrogenic barotrauma and its trends over time during the pandemic in COVID-19-positive patients undergoing mechanical ventilation compared to COVID-19-negative patients, making a distinction between different types of ventilation (invasive mechanical ventilation vs. noninvasive mechanical ventilation). We compared CT findings of pneumomediastinum and pneumothorax in 104 COVID-19-positive patients hospitalized in an intensive care unit and 101 COVID-19-negative patients undergoing mechanical ventilation in the period between October 2020 and December 2021. The severity of pneumonia was not directly correlated with the development of barotrauma. Furthermore, a higher prevalence of complications due to barotrauma was observed in the group of mechanically ventilated COVID-19-postive patients vs. COVID-19-negative patients. A higher rate of barotrauma was observed in subgroups of COVID-19-positive patients undergoing mechanical ventilation compared to those treated with invasive mechanical ventilation. The prevalence of barotrauma in COVID 19-positive patients showed a decreasing trend over the period under review. CT remains an essential tool in the early detection, diagnosis, and monitoring of the clinical course of SARS-CoV2 pneumonia; in evaluating the disease severity; and in the assessment of iatrogenic complications such as barotrauma pathology. Full article

(This article belongs to the Special Issue Emerging Trends in Therapy and Telemedicine for COVID-19)

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