Special Issue "Molecular Tissue Diagnosis of Fungal Infections"
Deadline for manuscript submissions: closed (1 February 2022) | Viewed by 20888
Despite progress in fungal diagnostics from respiratory specimens such as BAL and from easily obtained samples such as blood, the demonstration of fungal elements in host tissue is one of the pillars in the diagnosis of invasive fungal infections. The demonstration of fungal elements together with a tissue response is paramount for establishing the diagnosis of an invasive fungal disease.
The identification of causative agents by cultivation or morphological characteristics is considered to be important to guide patient management. However, as many fungi do not show discriminative morphologic features and cultures may fail to grow an organism even from samples with positive histopathology, molecular tools have been studied as an adjunct to classic diagnostic techniques.
Molecular tools may help identify the causative fungal species, providing information on intrinsic resistance patterns leading to optimized patient therapy. The use of specific antibodies or hybridization with oligonucleotides may localize one or more infecting agents in the disease process, establishing causality. Furthermore, strain typing or the detection of resistance determinants directly from tissue may clarify additional epidemiological issues.
While the potential of molecular tools to generate important insights leading to the improved management of individual patients and gaining insights into the epidemiology of invasive fungal infections is widely appreciated, a lack of standardization makes generalizations on their impact difficult.
This Special Issue welcomes reviews on best practices and novel approaches, systematic studies, case series or instructive case reports, as well as reports on quality control issues or standardization involving tissue for the diagnosis of invasive fungal infections using conventional and molecular techniques.
Dr. Volker Rickerts
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- epidemiology of invasive fungal infections