Special Issue "Current Challenges in the Diagnosis and Treatment of Hereditary and Congenital Aortopathies"
Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 57429
Interests: aortic valve repair; endovascular surgery; aortic valve surgery; aortic surgery; bicuspid aortic valve; mitral valve repair; minimal- invasive valve surgery; minimally invasive cardiac surgery
Special Issues, Collections and Topics in MDPI journals
Interests: Marfan syndrome; acute aortic syndromes; cardiogenetics
Interests: clinical cardiology; cardiology; chronic heart failure; cardiomyopathies; heart; heart valve diseases; pulmonary hypertension; congenital heart disease; aortic aneurysm; adult congenital heart disease
Congenital heart defects (CHDs)—which represent the most common isolated organ anomaly, with a prevalence of about 8.0 per 1000 live births—cause a steadily growing global health problem, as more than 90% of the affected patients now reach adulthood, as a result of modern treatment options. Unfortunately, most of them are not cured, and develop a wide range of residua and sub-sequels. CHD-associated aortic disease (so called aortopathy) is a very heterogeneous entity, and is prevalent in monogenetic aortic syndromes, congenital aortic valve disorders (i.e., unicuspid and bicuspid aortic valve), aortic coarctation, and cono-truncal anomalies (e.g., tetralogy of Fallot, transposition of great arteries), as well as in complex CHDs, such as hypoplastic left heart syndrome, and it is also seen after reparative cardiac surgery (e.g., after a Fontan operation). The pathogenesis of CHD-associated aortopathies is still incompletely understoodm and thus the best prevention and management strategy is currently unknown. From a clinical point of view, some specific aortopathies may be associated with an increased complication risk, especially an acute aortic syndrome. However, individualized risk stratification of adverse aortic events is only rudimentary, and therefore, CHD-associated aortopathies are currently under-diagnosed and not infrequently under- or over-treated. There is an urgent need for longitudinal data analyses of patients with CHD, particularly for those at risk of developing aortic complications. Furthermore, more integrative and translational research activities are indispensable for unravelling the mechanisms underlying the distinct forms of CHD-associated aortopathies, and to develop management strategies.
This Special Issue aims to address the knowledge gaps in the CHD-associated aortopathies, including review articles on the current state of the art in the diagnosis and treatment, as well as focused original contributions dealing with the distinct forms of hereditary and congenital aortopathies.
Prof. Dr. Evaldas Girdauskas
Prof. Dr. Yskert von Kodolitsch
Prof. Dr. Harald Kaemmerer
Manuscript Submission Information
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- congenital heart disease
- connective tissue disorders
- bicuspid aortic valve
- aortic coarctation
- aortic surgery