Special Issue "Thalassemia in 2017"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2017) | Viewed by 28251
Interests: thalassaemia; gene; clinical trial; progenitor cell; hematopoietic stem cell; hematology
Special Issues, Collections and Topics in MDPI journals
Topical Collection in Thalassemia Reports: Feature Papers in Thalassemia Reports
Interests: hematology; erythropoiesis; iron hemostasis; thalassemia; sickle cell anemia; iron overload; iron deficiency; bleeding disorders; thrombosis
2. Emory School of Medicine, Atlanta, USA
Interests: platelets; hematology; platelet aggregation; thrombosis; platelet activation; hemostasis; blood disorders; thalassemia
Thalassemias is an inherited blood disorder characterized by less hemoglobin and fewer red blood cells in your body than normal. There are two primary types of Thalassemia disease: α- and β-Thalassemia disease. Recent data suggest that the survival of well-treated patients with Thalassemia Major is now similar to that of Thalassemia Intermedia. In addition, retrospective data on 4943 subjects with a heterozygote state of beta-thalassemia, suggest that, even in patients defined as thalassemia carriers (Thalassemia Minor), there is an increase in morbidity (cirrhosis, kidney disease, etc.) compared with the non-thalassemia population of subjects who are not heterozygote. These data call for a potential revision of the clinical classification of thalassemia, based on strict categories of severity, towards a classification including a “continuum” of the same disease divided into its stages of manifestation. The advantages of this new classification would consist of:
- expand the use of chelation therapy and transfusion to the “traditionally” less severe forms of thalassemia syndromes for which management was not commonly considered;
- reduce the morbidity and mortality of such less severe forms of thalassemia syndromes;
- reduce health care costs associated with the treatment of these uncontrolled complications (cirrhosis, etc.) through prevention;
- expand the number of patients who have access and are eligible to innovative therapies;
- review the indications for prenatal diagnosis of Thalassemia Major;
In addition, this Special Issue of IJMS also gives insight into the evolving field of Thalassemias regarding research, diagnosis, treatment modalities and clinical applications.
Dr. Aurelio Maggio
Prof. Dr. Antonis Kattamis
Prof. Dr. Ali Taher
Dr. Khaled M. Musallam
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- blood disorder