Non-coding RNAs and Novel Therapeutic Targets in Human Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4103
Special Issue Editors
Interests: cancer biology; non-coding RNAs; lung cancer; small cell lung cancer; structure-based drug design and discovery
Interests: chemokines; cytokines; microRNAs; noncoding RNAs; breast cancer; lung cancer; brain metastasis; metastasis; experimental therapeutics; nanotechnology
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Special Issue Information
Dear Colleagues,
The ground rule for gene regulation has been pinpointed to protein-coding genes, ascribed to the central dogma of DNA-RNA-protein. However, the discovery of non-coding RNAs and their implications in RNA-interference (RNAi) has revolutionized the field of gene regulation and/or silencing, and this had a phenomenal contribution to the current understanding of transcriptomics and/or regulation-related puzzles in almost every form of life. Given the ‘central’ role of non-coding RNAs (ncRNAs) in the biology and disease progression of various cancers, the functional role of various ncRNAs needs to be investigated in detail. The last decade witnessed a huge surge in the amount of research focused on deciphering the functional implications of ncRNAs in understanding cancer and the subsequent development of anticancer therapies. Still, there is limited information available for the cancer-specific roles of long intergenic non-coding RNAs (lincRNAs) or long non-coding RNAs (lncRNAs) studied as pseudogenes, enhancers, epigenetic factors, and antisense molecules. The ncRNAs have established cancer-specific differential expression profiles that function as tumor suppressors or oncogenes. The recent advancement in RNA-sequencing technologies such as single-cell sequencing to study cancer cell transcriptomes established the role of ncRNAs in cancer initiation, progression, metastasis, and drug resistance. The scientific fraternity believes that ncRNAs will further revolutionize the field of cancer research, including diagnosis and therapeutic interventions.
Therefore, we are gratified to invite you to contribute to this Special Issue, ‘Non-coding RNAs and Novel Therapeutic Targets in Human Cancers’. This Special Issue aims to gather contributions from researchers working on translational and basic research in various cancers with the implications of ncRNAs. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular mechanisms establishing the functional role of ncRNAs in cancers.
- The implications of ncRNAs in tumor heterogeneity, lineage, and subtype specificities.
- The identification and characterization of ncRNA in circulating tumor cells or liquid biopsies for biomarker development.
- The role of ncRNAs in modulating drug resistance or therapy failure.
- Current approaches and future perspectives for the characterization of cancer-specific ncRNAs.
We look forward to receiving your contributions.
Dr. Parvez Khan
Dr. Mohd W. Nasser
Guest Editors
Manuscript Submission Information
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Keywords
- non-coding RNAs
- cancer therapeutics
- drug targets
- gene regulation
- tumor heterogeneity
- metastasis
- cancer metabolism
- immunotherapies.
