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Molecular Landscape of Cutaneous Wound Healing in Health and Disease
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Molecular Landscape of Cutaneous Wound Healing in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1466

Special Issue Editors

Prof. Dr. Massimo Conese

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Interests: nose-to-brain delivery; applications of nanoparticles to drug delivery; Parkinson’s disease; mucopenetration; mesenchymal stem cells; exosomes; airway diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Sante Di Gioia

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Interests: gene therapy of cystic fibrosis; cellular therapy of cystic fibrosis; CFTR “interactome”; pathophysiology of cystic fibrosis lung disease
Special Issues, Collections and Topics in MDPI journals
Dr. Annalucia Carbone

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Interests: mesenchymal stem cells; cystic fibrosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin wound healing is an orderly and highly coordinated process aiming to restore the cutaneous barrier function, consisting of four temporally overlapping phases, i.e., hemostasis, inflammation, proliferation, and tissue remodeling. A plethora of cell types (e.g., platelets, neutrophils, macrophages, endothelial cells, fibroblasts) participates in all these four stages, which represent a distinct equilibrium among pro- and anti-resolutive phenomena. For example, excessive inflammation delays wound healing by continued destruction of wound tissue, morbidity conditions such as vascular diseases, large areas, age, infection, diabetes, and many other factors may delay wound healing, resulting in chronic non-healing wounds. In current clinical practice, several treatments, such as wound dressings, skin autografts, and tissue engineered substitutes, and skin autografts are available for wound healing, however their effectiveness is mediocre. Therefore, it is urgent to understand the biological and molecular mechanisms to develop more effective treatments for wound healing. Since the molecular landscape of the wound healing process is still to be fully disclosed, the aim of this Special Issue is to highlight how cells interact with each other at the molecular level to ensue in the coordinated process of wound healing. From these contributions a new vision of molecular mediators and pathways will emerge indicating main avenues towards a novel potential chronic wound therapies.

  • Signal transduction pathways;
  • Transcription factors;
  • Cytokines;
  • Epigenetic regulation;
  • Stem cells;
  • Extracellular vesicles;
  • Tissue engineered scaffolds.

You may choose our Joint Special Issue in Pathophysiology.

Prof. Dr. Massimo Conese
Dr. Sante Di Gioia
Dr. Annalucia Carbone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic non-healing wounds
  • epidermal stem cells
  • Wnt
  • hydrogels
  • dermal regeneration templates
  • induced pluripotent stem cells
  • mesenchymal stem cells
  • exosomes
  • miRNA

Published Papers (2 papers)

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Review

30 pages, 2350 KiB  
Review
Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process
by Vivek Choudhary, Mrunal Choudhary and Wendy B. Bollag
Int. J. Mol. Sci. 2024, 25(7), 3790; https://doi.org/10.3390/ijms25073790 - 28 Mar 2024
Viewed by 550
Abstract
Cutaneous wound healing is a complex biological process involving a series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying skin wound repair and to evaluate potential therapeutic interventions. This review [...] Read more.
Cutaneous wound healing is a complex biological process involving a series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying skin wound repair and to evaluate potential therapeutic interventions. This review explores the diverse array of skin wound healing models utilized in research, ranging from rodent excisional wounds to advanced tissue engineering constructs and microfluidic platforms. More importantly, the influence of lipids on the wound healing process is examined, emphasizing their role in enhancing barrier function restoration, modulating inflammation, promoting cell proliferation, and promoting remodeling. Lipids, such as phospholipids, sphingolipids, and ceramides, play crucial roles in membrane structure, cell signaling, and tissue repair. Understanding the interplay between lipids and the wound microenvironment provides valuable insights into the development of novel therapeutic strategies for promoting efficient wound healing and tissue regeneration. This review highlights the significance of investigating skin wound healing models and elucidating the intricate involvement of lipids in the healing process, offering potential avenues for improving clinical outcomes in wound management. Full article
(This article belongs to the Special Issue Molecular Landscape of Cutaneous Wound Healing in Health and Disease)
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21 pages, 1920 KiB  
Review
Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges
by Karolina Kondej, Małgorzata Zawrzykraj, Katarzyna Czerwiec, Milena Deptuła, Agata Tymińska and Michał Pikuła
Int. J. Mol. Sci. 2024, 25(7), 3702; https://doi.org/10.3390/ijms25073702 - 26 Mar 2024
Viewed by 528
Abstract
Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. [...] Read more.
Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds. Full article
(This article belongs to the Special Issue Molecular Landscape of Cutaneous Wound Healing in Health and Disease)
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