Plant-Derived Phenolic Compounds: From Molecular Mechanisms to Clinical Application II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 232
Special Issue Editors
Interests: drug delivery using nanoparticles in vitro; cell imaging; cellular models of inflammation; natural antioxidants for airway epithelium; chronic respiratory diseases
Special Issues, Collections and Topics in MDPI journals
Interests: nose-to-brain delivery; applications of nanoparticles to drug delivery; Parkinson’s disease; mucopenetration; mesenchymal stem cells; exosomes; airway diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Plant-derived phenolic compounds, whose most important classes are flavonoids (i.e., catechin, epicatechin) quinones, stilbenes (i.e., resveratrol) and essential oils (i.e., thymol, carvacrol), are widely present in fruits, seeds, flowers, and leaves. They are have gained attention over time for the prevention and treatment of several diseases, since it has been shown that they have antioxidant, anti-carcinogenic, cardioprotective, neuroprotective and anti-inflammatory properties. It has been demonstrated that they slow tumor development through the inhibition of cell proliferation and induction of apoptosis. Moreover, they have also proved effective as cardioprotective agents by inhibiting the LDL oxidation involved in the pathogenesis of atherosclerosis. In addition, these have been proven to improve diabetic complications, such as neuropathy, retinopathy, or nephropathy. Phenolic compounds present strong antimicrobial activity, i.e., providing antiadhesive actions against bacteria in urinary and dental infections. Finally, these compounds can increase the migration of mesenchymal stem cells (MSCs) and enhance wound healing by regulating the functions and behavior of MSCs during immunomodulation. This Special Issue will shed light on various aspects related to phenolic extracts, and their extraction, synthesis and delivery, collecting contributions concerning advances related to their use in various research fields and novel research works aimed at obtaining new information on the biological features of these molecules in order to understand the mechanisms involved in their protective role, their bioavailability and their metabolism in human tissue.
Dr. Stefano Castellani
Prof. Dr. Massimo Conese
Guest Editors
Manuscript Submission Information
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Keywords
- phenolic compounds
- extraction and synthesis
- oxidative stress
- inflammation
- cancer
- neurodegenerative diseases
- cardiovascular diseases
- drug delivery
