Molecular Landscape of Cutaneous Wound Healing in Health and Disease

Dear Colleagues,

Skin wound healing is an orderly and highly coordinated process aiming to restore the cutaneous barrier function, consisting of four temporally overlapping phases, i.e., hemostasis, inflammation, proliferation, and tissue remodeling. A plethora of cell types (e.g., platelets, neutrophils, macrophages, endothelial cells, fibroblasts) participates in all these four stages, which represent a distinct equilibrium among pro- and anti-resolutive phenomena. For example, excessive inflammation delays wound healing by continued destruction of wound tissue, morbidity conditions such as vascular diseases, large areas, age, infection, diabetes, and many other factors may delay wound healing, resulting in chronic non-healing wounds. In current clinical practice, several treatments, such as wound dressings, skin autografts, and tissue engineered substitutes, and skin autografts are available for wound healing, however their effectiveness is mediocre. Therefore, it is urgent to understand the biological and molecular mechanisms to develop more effective treatments for wound healing. Since the molecular landscape of the wound healing process is still to be fully disclosed, the aim of this Special Issue is to highlight how cells interact with each other at the molecular level to ensue in the coordinated process of wound healing. From these contributions a new vision of molecular mediators and pathways will emerge indicating main avenues towards a novel potential chronic wound therapies.

• Signal transduction pathways;
• Transcription factors;
• Cytokines;
• Epigenetic regulation;
• Stem cells;
• Extracellular vesicles;
• Tissue engineered scaffolds.

You may choose our Joint Special Issue in International Journal of Molecular Sciences.

Prof. Dr. Massimo Conese
Dr. Annalucia Carbone
Dr. Sante Di Gioia
Guest Editors

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• chronic non-healing wounds
• epidermal stem cells
• WNT
• hydrogels
• dermal regeneration templates
• induced pluripotent stem cells
• mesenchymal stem cells
• exosomes
• miRNA