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State-of-the-Art of Molecular Genetics and Genomics in the 21st Century

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 1281

Special Issue Editor

Department of Laboratory Medicine & Pathology, Division of Anatomical Pathology, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H 8L1, Canada
Interests: genetics of the biliary system; mitochondrial DNA-related cardiomyopathies; CRISPR/Cas9 in osteosarcoma, and metabolic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human genome project has changed how medicine and science impact our lives. Canada is one of the leading countries in genomic initiatives and applications in medicine, science, agriculture, and manufacturing. In the 3rd decade of the 21st century, researchers are creating a bold vision for a platform generating solutions to global challenges. Public health agencies, private and public laboratories, Provincial Centers, and non-academic and academic institutions through the Genomics Networks are building solid initiatives for the present and the future. Environmental and economic issues accompany challenges that struggle with health and food supplies. We rely on the vigor of our research community and industry. Molecular genetics and genomics networks are built on a vast interconnection between researchers of different countries.

This Special Issue aims to provide a thorough overview of recent advances in molecular genetics and genomics in the 21st Century by inviting contributions from research institutes/laboratories that consolidate our understanding of this area. International collaborative papers are warmly welcome. In addition, we invite contributions from Canadian and non-Canadian researchers, which may include original research articles, review articles, editorials, and communications that provide insight into any current and future aspect of molecular genetics and genomes. Topics include but are not limited to:

  • Gene regulation, chromatin, and epigenetics;
  • Genome integrity, repair, and replication;
  • Genetic polymorphisms;
  • Microbiome and microbial genetics;
  • Plant genetics and genomics;
  • Agrigenomics and genomic responses to climate change;
  • Animal models and veterinary genomics;
  • Genes or genomes related to phenotypes and physiopathology;
  • Cancer genetics and epigenetics;
  • Pharmacogenetics and pharmacogenomics;
  • Toxicogenomics, nutrigenomics, and neurogenetics;
  • Data management, technology, and analytical developments of genomics;
  • Functional genomics;
  • Transcriptomics and metabolomics;
  • Cytogenetics and single-cell genomics.

Prof. Dr. Consolato M. Sergi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

14 pages, 5539 KiB  
Article
Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro
Int. J. Mol. Sci. 2023, 24(16), 12961; https://doi.org/10.3390/ijms241612961 - 19 Aug 2023
Viewed by 830
Abstract
Potential oncogene cleavage and polyadenylation specific factor 4 (CPSF4) has been linked to several cancer types. However, little research has been conducted on its function in prostate cancer (PCa). In benign, incidental, advanced, and castrate resistant PCa (CRPCa) patient samples, protein expression of [...] Read more.
Potential oncogene cleavage and polyadenylation specific factor 4 (CPSF4) has been linked to several cancer types. However, little research has been conducted on its function in prostate cancer (PCa). In benign, incidental, advanced, and castrate resistant PCa (CRPCa) patient samples, protein expression of CPSF4 was examined on tissue microarray (TMAs) of 353 PCa patients using immunohistochemistry. Using the ‘The Cancer Genome Atlas’ Prostate Adenocarcinoma (TCGA PRAD) database, significant correlations were found between high CPSF4 expression and high-risk genomic abnormalities such as ERG-fusion, ETV1-fusion, and SPOP mutations. Gene Set Enrichment Analysis (GSEA) of CPSF4 revealed evidence for the increase in biological processes such as cellular proliferation and metastasis. We further examined the function of CPSF4 in vitro and confirmed CPSF4 clinical outcomes and its underlying mechanism. Our findings showed a substantial correlation between Gleason groups and CPSF4 protein expression. In vitro, CPSF4 knockdown reduced cell invasion and migration while also causing G1 and G2 arrest in PC3 cell lines. Our findings demonstrate that CPSF4 may be used as a possible biomarker in PCa and support its oncogenic function in cellular proliferation and metastasis. Full article
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