Pediatric Liver Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 30493

Special Issue Editors

Special Issue Information

Dear Colleagues,

Pediatric hepatology has expanded in the last couple of decades as the amount of information of genetics, developmental biology, and metabolic studies has increased exponentially. This new Special Issue focusing on pediatric liver diseases has the intent to conglomerate research and review articles on several fields of the developing and damaged liver. The influence of the environment on liver diseases has grabbed our attention because of climate change but also because of the number of toxins that a child may be exposed to in developed and underdeveloped countries. The perspective of new clinical trials for autoimmune hepatitis and infectious liver diseases will be also part of this Special Issue. A section will also be reserved for imaging diagnostics. Digital images through a multitude of social media platforms and the introduction of new algorithms in artificial intelligence will help to efficiently and effectively implement new platforms of electronic medical records and approaches to personalized medicine.

Prof. Susan M. Gilmour
Prof. Consolato M. Sergi
Guest Editors

Manuscript Submission Information

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Keywords

  • liver
  • metabolism
  • cholangiopathy
  • cholestasis
  • radiology
  • pathology
  • therapy

Published Papers (4 papers)

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Editorial

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3 pages, 179 KiB  
Editorial
Acute Hepatitis of Unknown Origin (AHUO)—The Puzzle Ahead
by Consolato M. Sergi
Diagnostics 2022, 12(5), 1215; https://doi.org/10.3390/diagnostics12051215 - 12 May 2022
Cited by 3 | Viewed by 4296
Abstract
An intriguing form of hepatitis has been detected in more than a hundred children worldwide [...] Full article
(This article belongs to the Special Issue Pediatric Liver Diseases)

Review

Jump to: Editorial

13 pages, 1954 KiB  
Review
Biliary Atresia: A Complex Hepatobiliary Disease with Variable Gene Involvement, Diagnostic Procedures, and Prognosis
by Consolato M. Sergi and Susan Gilmour
Diagnostics 2022, 12(2), 330; https://doi.org/10.3390/diagnostics12020330 - 27 Jan 2022
Cited by 4 | Viewed by 4200
Abstract
The diagnosis of biliary atresia is still terrifying at the 3rd decade of the 21st century. In a department of neonatal intensive care unit, parents and physicians face a challenge with a jaundiced baby, who may or may not have a surgically correctable [...] Read more.
The diagnosis of biliary atresia is still terrifying at the 3rd decade of the 21st century. In a department of neonatal intensive care unit, parents and physicians face a challenge with a jaundiced baby, who may or may not have a surgically correctable hepatopathy. The approach has been systematically evaluated, but the etiology remains ambiguous. The study of families with recurrent biliary atresia has been undertaken at a molecular level. The primary interest with this disease is to identify the etiology and change the treatment from symptomatic to curative. The occurrence of this obstructive cholangio-hepatopathy in well-known genetic syndromes has suggested just coincidental finding, but the reality can be more intriguing because some of these diseases may have some interaction with the development of the intrahepatic biliary system. Several genes have been investigated thoroughly, including ADD3 and GPC1 shifting the interest from viruses to genetics. In this review, the intriguing complexities of this hepatobiliary disease are highlighted. Full article
(This article belongs to the Special Issue Pediatric Liver Diseases)
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30 pages, 7348 KiB  
Review
Pediatric Primary Hepatic Tumors: Diagnostic Considerations
by Bryony Lucas, Sanjita Ravishankar and Irina Pateva
Diagnostics 2021, 11(2), 333; https://doi.org/10.3390/diagnostics11020333 - 18 Feb 2021
Cited by 23 | Viewed by 8698
Abstract
The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well [...] Read more.
The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups. Full article
(This article belongs to the Special Issue Pediatric Liver Diseases)
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18 pages, 2978 KiB  
Review
Alagille Syndrome: Diagnostic Challenges and Advances in Management
by Mohammed D. Ayoub and Binita M. Kamath
Diagnostics 2020, 10(11), 907; https://doi.org/10.3390/diagnostics10110907 - 06 Nov 2020
Cited by 30 | Viewed by 11743
Abstract
Alagille syndrome (ALGS) is a multisystem disease characterized by cholestasis and bile duct paucity on liver biopsy in addition to variable involvement of the heart, eyes, skeleton, face, kidneys, and vasculature. The identification of JAG1 and NOTCH2 as disease-causing genes has deepened our [...] Read more.
Alagille syndrome (ALGS) is a multisystem disease characterized by cholestasis and bile duct paucity on liver biopsy in addition to variable involvement of the heart, eyes, skeleton, face, kidneys, and vasculature. The identification of JAG1 and NOTCH2 as disease-causing genes has deepened our understanding of the molecular mechanisms underlying ALGS. However, the variable expressivity of the clinical phenotype and the lack of genotype-phenotype relationships creates significant diagnostic and therapeutic challenges. In this review, we provide a comprehensive overview of the clinical characteristics and management of ALGS, and the molecular basis of ALGS pathobiology. We further describe unique diagnostic considerations that pose challenges to clinicians and outline therapeutic concepts and treatment targets that may be available in the near future. Full article
(This article belongs to the Special Issue Pediatric Liver Diseases)
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