Journal Browser

► Journal Browser

Special Issue "Sphingolipid Metabolism and Signaling: Role in Health and Diseases"

Share This Special Issue

Special Issue Editor

Special Issue Information

Dear Colleagues,

Sphingolipids are a class of lipids that are highly expressed in eukaryotic cells. Sphingolipids are ubiquitous components of cell membranes as well as bioactive molecules involved in the control of cell fate in physiological and pathophysiological processes. Sphingolipid metabolism and signaling are crucial for the maintenance of physiological conditions, but, on the other hand, the dysregulation of sphingolipid metabolism, leading to altered sphingolipid patterns, is associated with different pathological conditions. Sphingolipid levels are regulated via the modulation of the metabolism of specific enzymes as well as that of the specific receptors or transporters involved in their transport within or outside cells; however, the exact molecular mechanisms mediated by sphingolipids with which to modulate cell homeostasis are still not completely understood. New knowledge on the metabolism and signaling of sphingolipids will help in finding therapeutic solutions in a variety of human diseases.

For this Special Issue, “Sphingolipid Metabolism and Signaling: Role in Health and Diseases”, we welcome your contributions in the form of original research and review articles on all aspects of sphingolipids and their roles in physiological and pathophysiological processes.

Dr. Paola Giussani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

sphingolipids
sphingosine-1-phosphate
ceramide
glycosphingolipids
sphingolipid-mediated signaling
cancer
neurodegenerative diseases
inflammatory diseases
diabetes

Published Papers (2 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Review

Open AccessReview

Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications

Samar M. Hammad

and

Maria F. Lopes-Virella

Int. J. Mol. Sci. 2023, 24(18), 14015; https://doi.org/10.3390/ijms241814015 - 13 Sep 2023

Viewed by 307

Abstract

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2 diabetes, as well as in the development of both micro- and macro-vascular complications. Several reviews have been published concerning the role of sphingolipids in diabetes but most of the emphasis has been on the possible mechanisms by which sphingolipids, mainly ceramides, contribute to the development of diabetes. Research on circulating levels of the different classes of sphingolipids in serum and in lipoproteins and their importance as biomarkers to predict not only the development of diabetes but also of its complications has only recently emerged and it is still in its infancy. This review summarizes the previously published literature concerning sphingolipid-mediated mechanisms involved in the development of diabetes and its complications, focusing on how circulating plasma sphingolipid levels and the relative content carried by the different lipoproteins may impact their role as possible biomarkers both in the development of diabetes and mainly in the development of diabetic complications. Further studies in this field may open new therapeutic avenues to prevent or arrest/reduce both the development of diabetes and progression of its complications. Full article

(This article belongs to the Special Issue Sphingolipid Metabolism and Signaling: Role in Health and Diseases)

► Show Figures

Figure 1

Open AccessReview

Circulating Sphingolipids and Glucose Homeostasis: An Update

and

Int. J. Mol. Sci. 2023, 24(16), 12720; https://doi.org/10.3390/ijms241612720 - 12 Aug 2023

Viewed by 620

Abstract

Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. Of all sphingolipids, two species, ceramides and sphingosine-1-phosphate (S1P), are also found abundantly secreted into the bloodstream and associated with lipoproteins or extracellular vesicles. Plasma concentrations of these sphingolipids can be altered upon metabolic disorders and could serve as predictive biomarkers of these diseases. Recent important advances suggest that circulating sphingolipids not only serve as biomarkers but could also serve as mediators in the dysregulation of glucose homeostasis. In this review, advances of molecular mechanisms involved in the regulation of ceramides and S1P association to lipoproteins or extracellular vesicles and how they could alter glucose metabolism are discussed. Full article

(This article belongs to the Special Issue Sphingolipid Metabolism and Signaling: Role in Health and Diseases)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Sphingolipid Metabolism and Signaling: Role in Health and Diseases"

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (2 papers)

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI