Editorial Board Members’ Collection Series: Advances in Sphingolipids
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 194
Special Issue Editors
Interests: gangliosides; Parkinson’s disease; mebrane organization; complex lipids; sphingosine; ceramide
Special Issues, Collections and Topics in MDPI journals
Interests: sphingolipids; sphingosine-1-phosphate; ceramide; signaling; cancer; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sphingolipids are a large class of cell membrane amphiphilic components; however, they have also emerged as bioactive molecules. They contain a rigid lipid moiety characterized by the presence of the sphingosine. The structure of sphingolipids varies from the high-molecular-mass polisialylated glycosphingolipids to sphingomyelin and simple ceramides, sphingosines and their phosphorylated derivatives.
The determination of their structure was challenging and required over 50 years from the first information of their presence in the human brain. Nevertheless, after several decades of research and the involvement of many groups, the role played by sphingolipids in maintaining cell physiology is now becoming increasingly clear.
Depending on their structure, sphingolipids are involved in different processes, both physiological and pathological. Sphingolipids are necessary for correct neuronal development, maintaining interactions with cell surface proteins necessary for the modulation of a variety of cell signaling processes. On the other hand, their incorrect metabolism leads to serious neurodegenerative diseases, inflammation processes, cancer and lysosomal storage diseases.
Prof. Dr. Sandro Sonnino
Dr. Paola Giussani
Prof. Dr. Jin-ichi Inokuchi
Guest Editors
Manuscript Submission Information
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Keywords
- gangliosides
- glycosphingolipids
- sphingomyelin
- ceramide and ceramide phosphate
- sphingosine and sphingosine phosphate
