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Post-transcriptional Gene Expression Regulation in Eukaryotic Energy Metabolism
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Post-transcriptional Gene Expression Regulation in Eukaryotic Energy Metabolism

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 6385

Special Issue Editor

Dr. Je-Hyun Yoon

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, BSB 512B, MSC 509, Charleston, SC 29425, USA
Interests: ribonucleoproteins; posttranscriptional regulation; non-coding RNA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The role of signaling cascades and transcriptional gene expression regulation has been extensively studied in eukaryotic energy metabolism. These include metabolic regulatory pathways such as the insulin/IGF-1, AMPK, mTOR, and sirtuin pathways. However, the contribution of posttranscriptional gene expression regulation is incompletely understood. In this Special Issue, we solicit original research and review articles focusing on various metabolic pathways modulated in steps of mRNA decay, localization and translation. The contribution of noncoding RNAs such as miRNAs, lncRNAs and circRNAs to these regulatory pathways are other emphases. This Special Issue will offer new insight into the underlying molecular mechanisms of posttranscriptional regulatory networks for the modulation of eukaryotic energy metabolism.

Dr. Je-Hyun Yoon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eukaryotic energy metabolism
  • posttranscriptional regulatory networks
  • metabolic regulatory pathways
  • noncoding RNAs
  • molecular mechanisms

Published Papers (3 papers)

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Research

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15 pages, 2236 KiB  
Article
mTOR Contributes to the Proteome Diversity through Transcriptome-Wide Alternative Splicing
by Sze Cheng, Naima Ahmed Fahmi, Meeyeon Park, Jiao Sun, Kaitlyn Thao, Hsin-Sung Yeh, Wei Zhang and Jeongsik Yong
Int. J. Mol. Sci. 2022, 23(20), 12416; https://doi.org/10.3390/ijms232012416 - 17 Oct 2022
Cited by 2 | Viewed by 1774
Abstract
The mammalian target of rapamycin (mTOR) pathway is crucial in energy metabolism and cell proliferation. Previously, we reported transcriptome-wide 3′-untranslated region (UTR) shortening by alternative polyadenylation upon mTOR activation and its impact on the proteome. Here, we further interrogated the mTOR-activated transcriptome and [...] Read more.
The mammalian target of rapamycin (mTOR) pathway is crucial in energy metabolism and cell proliferation. Previously, we reported transcriptome-wide 3′-untranslated region (UTR) shortening by alternative polyadenylation upon mTOR activation and its impact on the proteome. Here, we further interrogated the mTOR-activated transcriptome and found that hyperactivation of mTOR promotes transcriptome-wide exon skipping/exclusion, producing short isoform transcripts from genes. This widespread exon skipping confers multifarious regulations in the mTOR-controlled functional proteomics: AS in coding regions widely affects the protein length and functional domains. They also alter the half-life of proteins and affect the regulatory post-translational modifications. Among the RNA processing factors differentially regulated by mTOR signaling, we found that SRSF3 mechanistically facilitates exon skipping in the mTOR-activated transcriptome. This study reveals a role of mTOR in AS regulation and demonstrates that widespread AS is a multifaceted modulator of the mTOR-regulated functional proteome. Full article
(This article belongs to the Special Issue Post-transcriptional Gene Expression Regulation in Eukaryotic Energy Metabolism)
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13 pages, 1582 KiB  
Article
Identification of Potential Biomarkers and Metabolic Pathways of Different Levels of Heat Stress in Beef Calves
by Won-Seob Kim, Jongkyoo Kim and Hong-Gu Lee
Int. J. Mol. Sci. 2022, 23(17), 10155; https://doi.org/10.3390/ijms231710155 - 05 Sep 2022
Cited by 3 | Viewed by 1823
Abstract
Heat stress (HS) damages the global beef industry by reducing growth performance causing high economic losses each year. However, understanding the physiological mechanisms of HS in Hanwoo calves remains elusive. The objective of this study was to identify the potential biomarkers and metabolic [...] Read more.
Heat stress (HS) damages the global beef industry by reducing growth performance causing high economic losses each year. However, understanding the physiological mechanisms of HS in Hanwoo calves remains elusive. The objective of this study was to identify the potential biomarkers and metabolic pathways involving different levels of heat stress in Hanwoo calves. Data were collected from sixteen Hanwoo bull calves (169.6 ± 4.6 days old, BW of 136.9 ± 6.2 kg), which were maintained at four designated ranges of HS according to the temperature–humidity index (THI) including: threshold (22 to 24 °C, 60%; THI = 70 to 73), mild (26 to 28 °C, 60%; THI = 74 to 76), moderate (29 to 31 °C, 80%; THI = 81 to 83), and severe (32 to 34 °C, 80%; THI = 89 to 91) using climate-controlled chambers. Blood was collected once every three days to analyze metabolomics. Metabolic changes in the serum of calves were measured using GC-TOF-MS, and the obtained data were calculated by multivariate statistical analysis. Five metabolic parameters were upregulated and seven metabolic parameters were downregulated in the high THI level compared with the threshold (p < 0.05). Among the parameters, carbohydrates (ribose, myo-inositol, galactose, and lactose), organic compounds (acetic acid, urea, and butenedioic acid), fatty acid (oleic acid), and amino acids (asparagine and lysine) were remarkably influenced by HS. These novel findings support further in-depth research to elucidate the blood-based changes in metabolic pathways in heat-stressed Hanwoo beef calves at different levels of THI. In conclusion, these results indicate that metabolic parameters may act as biomarkers to explain the HS effects in Hanwoo calves. Full article
(This article belongs to the Special Issue Post-transcriptional Gene Expression Regulation in Eukaryotic Energy Metabolism)
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Review

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12 pages, 945 KiB  
Review
Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses
by Kenzo Sakurai, Yuko Takeba, Yosuke Osada, Masanori Mizuno, Yoshimitsu Tsuzuki, Kentaro Aso, Keisuke Kida, Yuki Ohta, Masanori Ootaki, Taroh Iiri, Isamu Hokuto, Naoki Shimizu and Naoki Matsumoto
Int. J. Mol. Sci. 2022, 23(17), 10186; https://doi.org/10.3390/ijms231710186 - 05 Sep 2022
Cited by 2 | Viewed by 2258
Abstract
Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects [...] Read more.
Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects on other organs remain controversial. Furthermore, the effects of antenatal GC therapy on the fetal heart show both pros and cons. Translational research in animal models indicates that constant fetal exposure to antenatal GC administration is sufficient for lung maturation. We have established a premature fetal rat model to investigate immature cardiopulmonary functions in the lungs and heart, including the effects of antenatal GC administration. In this review, we explain the mechanisms of antenatal GC actions on the heart in the fetus compared to those in the neonate. Antenatal GCs may contribute to premature heart maturation by accelerating cardiomyocyte proliferation, angiogenesis, energy production, and sarcoplasmic reticulum function. Additionally, this review specifically focuses on fetal heart growth with antenatal GC administration in experimental animal models. Moreover, knowledge regarding antenatal GC administration in experimental animal models can be coupled with that from developmental biology, with the potential for the generation of functional cells and tissues that could be used for regenerative medical purposes in the future. Full article
(This article belongs to the Special Issue Post-transcriptional Gene Expression Regulation in Eukaryotic Energy Metabolism)
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