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Biology
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Editorial Board Members’ Collection Series: The Dynamics of RNA–Protein Interactions
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Editorial Board Members’ Collection Series: The Dynamics of RNA–Protein Interactions

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1927

Special Issue Editors

Dr. Je-Hyun Yoon

E-Mail Website
Guest Editor
Department of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA
Interests: microRNAs; lncRNAs; ribonucleoproteins; RNAomics; extracellular RNA; senescence; RNA localization
Special Issues, Collections and Topics in MDPI journals
Dr. Brett Keiper

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
Interests: regulated translation initiation of mRNA in differentiating and transformed cells

Special Issue Information

Dear Colleagues,

Dynamic interactions of RNA and protein allow eukaryotic cells to regulate various cellular processes, including mRNA splicing, decay, localization, translation, and many others, under normal or stress conditions. The maintenance of RNA and protein interactions preserve cellular integrity, and the loss of these regulatory processes frequently drive numerous human diseases.

In this Special Issue, entitled “Editorial Board Members’ Collection Series: The Dynamics of RNA–Protein Interactions”, we welcome original relevant research articles and reviews which highlight the dynamic regulatory mechanisms underlying RNA and protein interactions, ultimately aiming to improve current knowledge of RNA biology and contributing to human health. Potential research areas include (but are not limited to): basic research and methodology into RNA and protein interactions performed by RNA-binding proteins, mRNAs, and noncoding RNAs. We have an additional interest in the accumulation of these biomolecules in subcellular organelles and specialized compartments like RNA granules and membraneless organelles.

We look forward to receiving your contributions.

Dr. Je-Hyun Yoon
Dr. Brett Keiper
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA-binding proteins
  • mRNA splicing
  • mRNA decay
  • mRNA translation
  • RNA localization
  • microRNAs
  • siRNAs
  • long noncoding RNAs
  • phase separation
  • RNA granules
  • membraneless organelles

Published Papers (1 paper)

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Research

16 pages, 2671 KiB  
Article
Low-Dose Ionizing Radiation-Crosslinking Immunoprecipitation (LDIR-CLIP) Identified Irradiation-Sensitive RNAs for RNA-Binding Protein HuR-Mediated Decay
by Ji Won Lee, Hyejin Mun, Jeong-Hyun Kim, Seungbeom Ko, Young-Kook Kim, Min Ji Shim, Kyungmin Kim, Chul Woong Ho, Hyun Bong Park, Meesun Kim, Chaeyoung Lee, Si Ho Choi, Jung-Woong Kim, Ji-Hoon Jeong, Je-Hyun Yoon, Kyung-Won Min and Tae Gen Son
Biology 2023, 12(12), 1533; https://doi.org/10.3390/biology12121533 - 15 Dec 2023
Viewed by 1392
Abstract
Although ionizing radiation (IR) is widely used for therapeutic and research purposes, studies on low-dose ionizing radiation (LDIR) are limited compared with those on other IR approaches, such as high-dose gamma irradiation and ultraviolet irradiation. High-dose IR affects DNA damage response and nucleotide–protein [...] Read more.
Although ionizing radiation (IR) is widely used for therapeutic and research purposes, studies on low-dose ionizing radiation (LDIR) are limited compared with those on other IR approaches, such as high-dose gamma irradiation and ultraviolet irradiation. High-dose IR affects DNA damage response and nucleotide–protein crosslinking, among other processes; however, the molecular consequences of LDIR have been poorly investigated. Here, we developed a method to profile RNA species crosslinked to an RNA-binding protein, namely, human antigen R (HuR), using LDIR and high-throughput RNA sequencing. The RNA fragments isolated via LDIR-crosslinking and immunoprecipitation sequencing were crosslinked to HuR and protected from RNase-mediated digestion. Upon crosslinking HuR to target mRNAs such as PAX6, ZFP91, NR2F6, and CAND2, the transcripts degraded rapidly in human cell lines. Additionally, PAX6 and NR2F6 downregulation mediated the beneficial effects of LDIR on cell viability. Thus, our approach provides a method for investigating post-transcriptional gene regulation using LDIR. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: The Dynamics of RNA–Protein Interactions)
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