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Functionalization of Carbon-Based Nanomaterials for Biomedical Application
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Functionalization of Carbon-Based Nanomaterials for Biomedical Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 5351

Special Issue Editor

Prof. Dr. Ana María Díez-Pascual

E-Mail Website
Guest Editor
Departamento de Química Analítica, Química Física e Ingeniería Química, Facultad de Ciencias, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
Interests: nanomaterials; polymers; nanocomposites; inorganic nanoparticles; antibacterial agents; surfactants; interphases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbon-based nanomaterials, such as carbon nanotubes, graphene and its derivatives, nanodiamonds, fullerenes, and other nano-sized carbon allotropes, are nowadays one of the most promising materials for a wide range of applications, especially medicine. The immeasurable possibilities associated with modifying and tailoring carbon nanomaterials are associated with their small size, approaching the size of many fundamental biomolecules. The use of chemical and physical methods for the functionalization of carbon nanomaterials makes it possible to modify their structure, which will enable us to optimize the physicochemical characteristics for each specific application.

This Special Issue aims to offer a forum for the publication of original research/review articles regarding carbon-based nanomaterials for biomedical and biological applications. Novel surface modifications of carbon nanomaterials to tailor their physico-chemical properties are welcomed. Articles can include (but are not limited to) the following topics:

  • structure of functionalized carbon-based nanomaterials;
  • functionalization methods (physical, chemical, radiation, and ion-plasma methods);
  • composites based on nanostructured carbon and polymers, metals, metal oxide particles, etc.;
  • doping of carbon materials with heteroatoms;
  • modelling the structure and properties of modified carbon-based materials;
  • biosensor applications.

We wish this issue to reflect the plethora of carbon nanomaterials and the variety of functionalization strategies that have been developed in order to enhance their properties, especially for biomedical uses.

Prof. Dr. Ana María Díez-Pascual
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Carbon nanomaterials (graphene, graphene oxides, carbon nanotubes, fullerenes, etc.)
  • Chemical functionalization
  • Plasma functionalization
  • Physical functionalization
  • Biomedical applications

Published Papers (3 papers)

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Research

9 pages, 2598 KiB  
Article
The Influence of Graphene Content on the Antibacterial Properties of Polycaprolactone
by Maciej B. Hajduga, Rafał Bobinski, Mieczysław Dutka, Jan Bujok, Michał Cwiertnia, Celina Pajak, Anna Kurowska and Izabella Rajzer
Int. J. Mol. Sci. 2022, 23(18), 10899; https://doi.org/10.3390/ijms231810899 - 17 Sep 2022
Cited by 9 | Viewed by 1343
Abstract
This work contains an analysis of the impact of modifying a bioresorbable polymer—polycaprolactone (PCL)—with various additives on its antibacterial properties. To this end, samples of PCL filament containing various content levels of graphene (GNP), 0.5%, 5%, 10%, were obtained using injection molding. Polymer [...] Read more.
This work contains an analysis of the impact of modifying a bioresorbable polymer—polycaprolactone (PCL)—with various additives on its antibacterial properties. To this end, samples of PCL filament containing various content levels of graphene (GNP), 0.5%, 5%, 10%, were obtained using injection molding. Polymer samples without additives were used for comparison. The next step was to assess the antimicrobial impact of the preparations under study against the following microorganisms: Staphylococcus aureus ATCC 25293, Escherichia coli ATCC 25922, Candida albicans ATCC 10231. Effective bactericidal activity of PCL with small amount of GNP, especially against C. albicans and S. aureus was confirmed. A decrease in this property or even multiplication of microorganisms was observed in direct proportion to the graphene content in the samples. Full article
(This article belongs to the Special Issue Functionalization of Carbon-Based Nanomaterials for Biomedical Application)
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17 pages, 4797 KiB  
Article
Carbon Metabolism of a Soilborne Mn(II)-Oxidizing Escherichia coli Isolate Implicated as a Pronounced Modulator of Bacterial Mn Oxidation
by Tong Gu, Zhenghu Tong, Xue Zhang, Zhiyong Wang, Zhen Zhang, Tzann-Shun Hwang and Lin Li
Int. J. Mol. Sci. 2022, 23(11), 5951; https://doi.org/10.3390/ijms23115951 - 25 May 2022
Cited by 1 | Viewed by 1481
Abstract
Mn(II)-oxidizing microorganisms are generally considered the primary driving forces in the biological formation of Mn oxides. However, the mechanistic elucidation of the actuation and regulation of Mn oxidation in soilborne bacteria remains elusive. Here, we performed joint multiple gene-knockout analyses and comparative morphological [...] Read more.
Mn(II)-oxidizing microorganisms are generally considered the primary driving forces in the biological formation of Mn oxides. However, the mechanistic elucidation of the actuation and regulation of Mn oxidation in soilborne bacteria remains elusive. Here, we performed joint multiple gene-knockout analyses and comparative morphological and physiological determinations to characterize the influence of carbon metabolism on the Mn oxide deposit amount (MnODA) and the Mn oxide formation of a soilborne bacterium, Escherichia coli MB266. Different carbon source substances exhibited significantly varied effects on the MnODA of MB266. A total of 16 carbon metabolism-related genes with significant variant expression levels under Mn supplementation conditions were knocked out in the MB266 genome accordingly, but only little effect on the MnODA of each mutant strain was accounted for. However, a simultaneous four-gene-knockout mutant (namely, MB801) showed an overall remarkable MnODA reduction and an initially delayed Mn oxide formation compared with the wild-type MB266. The assays using scanning/transmission electron microscopy verified that MB801 exhibited not only a delayed Mn-oxide aggregate processing, but also relatively smaller microspherical agglomerations, and presented flocculent deposit Mn oxides compared with normal fibrous and crystalline Mn oxides formed by MB266. Moreover, the Mn oxide aggregate formation was highly related to the intracellular ROS level. Thus, this study demonstrates that carbon metabolism acts as a pronounced modulator of MnODA in MB266, which will provide new insights into the occurrence of Mn oxidation and Mn oxide formation by soilborne bacteria in habitats where Mn(II) naturally occurs. Full article
(This article belongs to the Special Issue Functionalization of Carbon-Based Nanomaterials for Biomedical Application)
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11 pages, 3752 KiB  
Article
Synthesis of Porous Polydimethylsiloxane Gold Nanoparticles Composites by a Single Step Laser Ablation Process
by Mariapompea Cutroneo, Vladimir Havranek, Anna Mackova, Petr Malinsky, Letteria Silipigni, Petr Slepicka, Dominik Fajstavr and Lorenzo Torrisi
Int. J. Mol. Sci. 2021, 22(22), 12155; https://doi.org/10.3390/ijms222212155 - 10 Nov 2021
Cited by 6 | Viewed by 1653
Abstract
Typically, polymeric composites containing nanoparticles are realized by incorporating pre-made nanoparticles into a polymer matrix by using blending solvent or by the reduction of metal salt dispersed in the polymeric matrix. Generally, the production of pre-made Au NPs occurs in liquids with two-step [...] Read more.
Typically, polymeric composites containing nanoparticles are realized by incorporating pre-made nanoparticles into a polymer matrix by using blending solvent or by the reduction of metal salt dispersed in the polymeric matrix. Generally, the production of pre-made Au NPs occurs in liquids with two-step processes: producing the gold nanoparticles first and then adding them to the liquid polymer. A reproducible method to synthetize Au nanoparticles (NPs) into polydimethylsiloxane (PDMS) without any external reducing or stabilizing agent is a challenge. In this paper, a single-step method is proposed to synthetize nanoparticles (NPs) and at the same time to realize reproducible porous and bulk composites using laser ablation in liquid. With this single-step process, the gold nanoparticles are therefore produced directly in the liquid polymer. The optical properties of the suspensions of AuNPs in distilled water and in the curing agent have been analyzed by the UV-VIS spectroscopy, employed in the transmission mode, and compared with those of the pure curing agent. The electrical dc conductivity of the porous PDMS/Au NPs nanocomposites has been evaluated by the I–V characteristics. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis have monitored the composition and morphology of the so-obtained composites and the size of the fabricated Au nanoparticles. Atomic force microscopy (AFM) has been used to determine the roughness of the bulk PDMS and its Au NP composites. Full article
(This article belongs to the Special Issue Functionalization of Carbon-Based Nanomaterials for Biomedical Application)
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