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Role of Natural Products and Derivatives in Tumor

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 2452

Special Issue Editor

Special Issue Information

Dear Colleagues, 

Inflammation is related with the development of cancer. Chronic inflammation has been associated with cancer and tumorigenesis such as survival, tumor promotion, proliferation, resistance, invasion, cellular transformation, metastasis, and angiogenesis. Inflammation-mediated cancer can be caused various mutation types to multifunction of tumor suppressors or oncogenes. Moreover, it is results in the secretion of pro-inflammatory cytokines and chemokines by immune or cancer cells. Recently, natural products and their derivatives have potential roles in the development of new drugs and pharmaceutical strategy against cancer, immune disease, and chronic inflammation, etc. Increased research reported anti-cancer and anti-inflammatory natural products including polysaccharides, saponins, capsaicin, polyphenols, terpenoids, etc and then they have potential immunomodulatory effects in cancer and inflammatory disease. The immunoregulation mechanisms of natural products and their derivatives are involved diverse signal transduction pathway against cancer and inflammatory diseases. However, there is still a considerable obstacle in treating natural products and their derivatives as novel therapeutic strategies.

This Special Issue of IJMS, “Role of Natural Products and Derivatives in Tumor” will focus on the new advance therapeutic strategies to overcome inflammation and cancer by natural products and active compounds in various immune or cancer models. Therefore, we will suggest progress in the understanding of various signal transduction pathway and focus on therapeutic approaches to develop new treatments to overcome inflammation and cancer.

Dr. Tae Woo Kim
Guest Editor

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Research

15 pages, 1551 KiB  
Article
Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
by Tae Woo Kim
Int. J. Mol. Sci. 2023, 24(10), 9076; https://doi.org/10.3390/ijms24109076 - 22 May 2023
Cited by 5 | Viewed by 2099
Abstract
Fisetin, a well-known plant flavonol from the natural flavonoid group, is found in traditional medicines, plants, vegetables, and fruits. Fisetin also has anti-oxidant, anti-inflammatory, and anti-tumor effects. This study investigated the anti-inflammatory effects of fisetin in LPS-induced Raw264.7 cells and found that fisetin [...] Read more.
Fisetin, a well-known plant flavonol from the natural flavonoid group, is found in traditional medicines, plants, vegetables, and fruits. Fisetin also has anti-oxidant, anti-inflammatory, and anti-tumor effects. This study investigated the anti-inflammatory effects of fisetin in LPS-induced Raw264.7 cells and found that fisetin reduced the LPS-induced production of pro-inflammation markers, such as TNF-α, IL-1β, and IL-6, demonstrating the anti-inflammatory effects of fisetin. Furthermore, this study investigated the anti-cancer effects of fisetin and found that fisetin induced apoptotic cell death and ER stress through intracellular calcium (Ca2+) release, the PERK-ATF4-CHOP signaling pathway, and induction of GRP78 exosomes. However, the suppression of PERK and CHOP inhibited the fisetin-induced cell death and ER stress. Interestingly, fisetin induced apoptotic cell death and ER stress and inhibited the epithelial-mesenchymal transition phenomenon under radiation in radiation-resistant liver cancer cells. These findings indicate that the fisetin-induced ER stress can overcome radioresistance and induce cell death in liver cancer cells following radiation. Therefore, the anti-inflammatory agent fisetin, in combination with radiation, may be a powerful immunotherapy strategy to overcome resistance in an inflammatory tumor microenvironment. Full article
(This article belongs to the Special Issue Role of Natural Products and Derivatives in Tumor)
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